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- Pharmacology For Clioquinol + Betamethasone valerate
Clioquinol + Betamethasone valerate Pharmacology
Clioquinol + Betamethasone valerateAbout Clioquinol + Betamethasone valerateN/AMechanism of Action of Clioquinol + Betamethasone valerateN/APharmacokinets of Clioquinol + Betamethasone valerateN/AOnset of Action for Clioquinol + Betamethasone valerateN/ADuration of Action for Clioquinol + Betamethasone valerateN/AHalf Life of Clioquinol + Betamethasone valerateN/ASide Effects of Clioquinol + Betamethasone valerateN/AContra-indications of Clioquinol + Betamethasone valerateN/ASpecial Precautions while taking Clioquinol + Betamethasone valerateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Clioquinol + Betamethasone valerateN/AInteractions for Clioquinol + Betamethasone valerateN/ATypical Dosage for Clioquinol + Betamethasone valerateN/ASchedule of Clioquinol + Betamethasone valerateN/AStorage Requirements for Clioquinol + Betamethasone valerateN/AEffects of Missed Dosage of Clioquinol + Betamethasone valerateN/AEffects of Overdose of Clioquinol + Betamethasone valerateN/A
ClioquinolAbout ClioquinolHydroxyquinolines derivative, Antifungal drug , Antibacterial and antiprotozoal.Mechanism of Action of ClioquinolClioquinol topical is an antifungal and antibacterial medication. Clioquinol topical prevents fungus from growing on skin.Pharmacokinets of ClioquinolN/AOnset of Action for ClioquinolN/ADuration of Action for ClioquinolN/AHalf Life of ClioquinolN/ASide Effects of Clioquinol1.Blistering
7.Irritation of the skin.
Contra-indications of Clioquinol1.Hypersensitivity to ClioquinolSpecial Precautions while taking ClioquinolN/APregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Clioquinol1.Eczema
Interactions for ClioquinolN/ATypical Dosage for ClioquinolClean and dry the affected area. Apply a small amount of the cream two or three times daily as directed for up to 1 week. Schedule of ClioquinolN/AStorage Requirements for ClioquinolStore in cool, dry and dark place.Keep out of the reach of children.Effects of Missed Dosage of ClioquinolApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ClioquinolGive symptomatic and supportive treatment
Betamethasone valerateAbout Betamethasone valerateIt is a topical steroid
Mechanism of Action of Betamethasone valerateThe drug exerts it`s pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemotaxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Betamethasone valerateAbsorption: It is absorbed in to the systemic circulation and the amount is depending on the potency, amount applied and the nature of the skin at the site of application. Absorption increases at the site of skin damage, inflammation or occlusion.
Onset of Action for Betamethasone valerateN/ADuration of Action for Betamethasone valerateN/AHalf Life of Betamethasone valerateN/ASide Effects of Betamethasone valerate1.Thinning of the skin
2.Loss of elasticity
3.Increased hair growth
4.Acne at the site of application
Contra-indications of Betamethasone valerate1.Untreated bacterial, virus or fungal infections
6.Tuberculosis of the skin,
8.Skin lesions caused by infections with ring worm,. fungi (e.g. Candida, Tinea) or bacteria (e.g. impetigo)
9.Hypersensitivity to Betamethasone and other corticosteroids.
10.Discoid lupus Erythematosus
Special Precautions while taking Betamethasone valerate1.Avoid contact with eyes
2.For external use only
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Betamethasone valerate1.Psoriasis,
4.Lichen simplex and planus,
5.Anal and vulval Pruritis,
8.Steroidal responsive dermatoses of the scalp
Interactions for Betamethasone valerateN/ATypical Dosage for Betamethasone valerateTopical:
Betamethasone Valerate: Apply to the affected area as thin film 1 - 4 times daily depending upon the severity, skin and rate of absorption.
Dermatoses of the scalp: (Betamethasone Valerate 0.12%): Small amount of foam is applied in to the scalp with gentle massage 2 times a day for up to 2 weeks.
Schedule of Betamethasone valerateN/AStorage Requirements for Betamethasone valerateStore at room temperature in a well closed; light resistant container. Protect from excess heat and moisture. Keep out of reach of children.Effects of Missed Dosage of Betamethasone valerateApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Betamethasone valerateProvide symptomatic treatment and supportive measures.
Home Delivery for Clioquinol + Betamethasone valerate in Your City
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