Neomycin + Clostebol Pharmacology

Neomycin + Clostebol

About Neomycin + Clostebol
It is a topical steroid.
Mechanism of Action of Neomycin + Clostebol
Clostebol is an anabolic steroid. It enhances retention and fixation of nitrogen of mineral salts and other substances necessary for protein synthesis. It stimulates tissue regeneration and therefore used in the treatment of repair of ulcers, leisions and skin dystrophies.
Pharmacokinets of Neomycin + Clostebol
Absorption: Clostebol is absorbed through intact skin after topical administration.
Onset of Action for Neomycin + Clostebol
N/A
Duration of Action for Neomycin + Clostebol
N/A
Half Life of Neomycin + Clostebol
N/A
Side Effects of Neomycin + Clostebol
1.Thinning of epidermis
2.Burning
3.Itching
4.Irritation
5.Atrophy (Dermal changes)
6.Striae
7.Hypopigmentation
8.Dryness
9.Folliculitis
10.Acneform drug eruptions
Contra-indications of Neomycin + Clostebol
1.Hypersensitivity to Clostebol and other corticosteroids
2 Tuberculosis infection of the skin
3.Viral fungal or bacterial primary infections
4.Ulcers
Special Precautions while taking Neomycin + Clostebol
1.For external use only
2.Avoid abrupt withdrawal
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Neomycin + Clostebol
1.Ulcerated wounds
2.Pressure sores and bed sores
3.Nipple and anal fissures
4.Radiation reactions
5.Erosions and abrasions
6. Infected wounds
7.1st and 2nd degree burns
Interactions for Neomycin + Clostebol
N/A
Typical Dosage for Neomycin + Clostebol
Topical: Clostebol 0.5 % cream is used. Apply the medicament thinly and evenly with gentle massage on the affected area 1-2times daily for maximum 2 weeks.
Schedule of Neomycin + Clostebol
N/A
Storage Requirements for Neomycin + Clostebol
Store at room temperature. Protect from heat and light. Keep out of the reach of children
Effects of Missed Dosage of Neomycin + Clostebol
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Neomycin + Clostebol
Give supportive measures and symptomatic treatment.

Neomycin

About Neomycin
An aminoglycoside, Antibiotic, Ammonium Detoxicant.
Mechanism of Action of Neomycin
This aminoglycoside cause protein synthesis inhibition by "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically Neomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.
Pharmacokinets of Neomycin
Absorption- Poorly absorbed after oral administration
Distribution- Rapidly distributed in the body after oral administration. 30% bound to the plasma proteins. It crosses the placenta
Metabolism- Not metabolized
Excretion- Excreted through urine and feces (primarily as unchanged form). It also excreted through breast milk
Onset of Action for Neomycin
1 to 4 hr after oral administration
Duration of Action for Neomycin
8hrs after oral administration
Half Life of Neomycin
Its plasma half life is 2 to 3 hrs
Side Effects of Neomycin
1. Rash
2. Diarrhoea
3. Inflammation of the large intestine (colitis)
4. Nausea
5. Vomiting
6. Ototoxicity
7. Damage to the kidneys
8. Damage to vestibular function within the ear
Contra-indications of Neomycin
1. Hypersensitivity to the drug or any ingredients of it
2. Hypersensitivity to other amino glycosides
3. Intestinal obstruction
Special Precautions while taking Neomycin
1. Impaired renal function
2. Neuromuscular disorder
3. Ulcerative bowel lesions
4. Extensive dermatologic conditions
5. Any other eye infection or condition
6. Glaucoma
7. Cataract surgery
8. Blockage of the bowel
9. Eighth-cranial-nerve disease (loss of hearing and/or balance)
10. Kidney disease
11. Myasthenia gravis
12. Parkinson`s disease
13. Ulcers of the bowel
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Neomycin
1. Coma due to liver disease
2. Preventing infection following surgery
3. Topical infections
4. Systemic infections
Interactions for Neomycin
N/A
Typical Dosage for Neomycin
Ophthalmic suspension:
Adults-
1 or 2 drops every three or four hours- For eye infection
Oral (solution, tablets):
Adults and teenagers-
1 to 3 grams every six hours for five or six days- coma from liver disease
Adults and teenagers-
1 gram every hour for four hours, then 1 gram every four hours for the rest of a twenty-four hour period; or 1 gram nineteen hours before surgery, 1 gram eighteen hours before surgery, and 1 gram nine hours before surgery- cleaning the bowel before surgery.
Children-
14.7 milligrams mg/kg or 6.7 mg/ pound every four hours for three days
Ear preparation:
Adults and children-
2 to 5 drops into ear canal 3 to 4 times daily for 7 to 10 days- External ear canal infection
Schedule of Neomycin
C
Storage Requirements for Neomycin
Eye preparations store in the refrigerator protected from strong light. Do not freeze. Others are stored at <250C. Keep out of reach of children.
Effects of Missed Dosage of Neomycin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Neomycin
Give symptomatic and supportive treatment. Provide haemodialysis or peritoneal dialysis to remove the drug. Treated with calcium salts or anticholinesterase to reverses neuromuscular blockade. Administer activated charcoal to prevent the further absorption of drug

Clostebol

About Clostebol
N/A
Mechanism of Action of Clostebol
Clostebol is an anabolic steroid. It enhances retention and fixation of nitrogen of mineral salts and other substances necessary for protein synthesis. It stimulates tissue regeneration and therefore used in the treatment of repair of ulcers, leisions and skin dystrophies.

Pharmacokinets of Clostebol
Absorption: Clostebol is absorbed through intact skin after topical administration.
Onset of Action for Clostebol
N/A
Duration of Action for Clostebol
N/A
Half Life of Clostebol
N/A
Side Effects of Clostebol
1.Thinning of epidermis
2.Burning
3.Itching
4.Irritation
5.Atrophy (Dermal changes)
6.Striae
7.Hypopigmentation
8.Dryness
9.Folliculitis
10.Acneform drug eruptions
Contra-indications of Clostebol
1.Hypersensitivity to Clostebol and other corticosteroids
2.Tuberculosis infection of the skin
3.Viral, fungal or bacterial primary infections
4.Ulcers
Special Precautions while taking Clostebol
1.For external use only
2.Avoid abrupt withdrawal
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Clostebol
1.Ulcerated wounds
2.Pressure sores and bed sores
3.Nipple and anal fissures
4.Radiation reactions
5.Erosions and abrasions
6. Infected wounds
7.1st and 2nd degree burns
Interactions for Clostebol
N/A
Typical Dosage for Clostebol
Topical: Clostebol 0.5 % cream is used. Apply the medicament thinly and evenly with gentle massage on the affected area 1-2 times daily for maximum 2 weeks
Schedule of Clostebol
h
Storage Requirements for Clostebol
Store at room temperature. Protect from heat and light. Keep out of the reach of children
Effects of Missed Dosage of Clostebol
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Clostebol
Give supportive measures and symptomatic treatment.

Home Delivery for Neomycin + Clostebol in Your City

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Neomycin + Clostebol is a generic medicine name and there are several brands available for it. Some of the brands for neomycin + clostebol might be better known than neomycin + clostebol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have neomycin + clostebol in stock, you can ask for one of the branded alternatives for neomycin + clostebol.