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- Pharmacology For Gentamicin + Clobetasone butyrate
Gentamicin + Clobetasone butyrate Pharmacology
Gentamicin + Clobetasone butyrate
About Gentamicin + Clobetasone butyrateN/AMechanism of Action of Gentamicin + Clobetasone butyrateN/APharmacokinets of Gentamicin + Clobetasone butyrateN/AOnset of Action for Gentamicin + Clobetasone butyrateN/ADuration of Action for Gentamicin + Clobetasone butyrateN/AHalf Life of Gentamicin + Clobetasone butyrateN/ASide Effects of Gentamicin + Clobetasone butyrateN/AContra-indications of Gentamicin + Clobetasone butyrateN/ASpecial Precautions while taking Gentamicin + Clobetasone butyrateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Gentamicin + Clobetasone butyrateN/AInteractions for Gentamicin + Clobetasone butyrateN/ATypical Dosage for Gentamicin + Clobetasone butyrateN/ASchedule of Gentamicin + Clobetasone butyrateN/AStorage Requirements for Gentamicin + Clobetasone butyrateN/AEffects of Missed Dosage of Gentamicin + Clobetasone butyrateN/AEffects of Overdose of Gentamicin + Clobetasone butyrateN/AGentamicin
About GentamicinAminoglycoside antibiotic.Mechanism of Action of GentamicinGentamicin exerts its bactericidal action against gram negative organisms & some of gram positive organisms by inhibiting bacterial protein synthesis. The process involves 1. Penetration of bacterial cell membrane & binding directly to the bacterial ribosome, 2. Misleading of m-RNA codon by bacterial ribosome, 3. Formation of peptide chains with wrong amino acid sequence which gets incorporated into bacterial cell membrane and alters its permeability, 4. Bacterial cell lysis. Some bacterial strains resistant to other amino glycosides are sensitive to Gentamicin.
Pharmacokinets of GentamicinAbsorption: Poorly absorbed orally
Distribution: Distributed extracellularly. CSF penetration & intraocular penetration poor.
Metabolism: Not metabolized
Excretion: Excreted mainly through urine.
Onset of Action for Gentamicin1 hour
Duration of Action for Gentamicin8 hoursHalf Life of Gentamicin2 hoursSide Effects of Gentamicin1. Vestibular damage & Ototoxicity
2. Allergic manifestations
3. Nephrotoxicity
4. Dizziness
5. Nausea
6. Vomiting
7. Seizures
Contra-indications of Gentamicin1. Hypersensitive to the drug or other amino glycosides
2. Along with chloramphenicol or tetracycline
3. Renal impairment
4. Labyrinthine disorders
Special Precautions while taking Gentamicin1. Renal impairment
2. Neuromuscular disorders
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with caution
Breast Feeding Related InformationContraindicated
Children Related InformationUse with caution
Infants : Use with caution
Indications for Gentamicin1. Infections caused by staphylococci, pseudomonas, proteous, klebsiella, enterobacter & serratia.
2. Meningitis.
3. Endocarditis
4. Urinary Tract Infections.
5. Otitis & Ocular infections.
6. Infections of burns & Skin ulcers
Interactions for GentamicinAmphotericin B, Cisplatin, Cephalosporin, Vancomycin, Methoxyflurane, Frusemide, Bumetanide: Increased nephrotoxicity.
Anaesthetics, Neuromuscular blocking agents (Tubocurarine): Risk of neuromuscular blockade and respiratory paralysis.
Penicillin, Cephalosporins, Carbenicillin, Ticarcillin: Exert antibiotic synergism, especially useful in Pseudomonas infections.
Loop diuretics: Concurrent use of these agents may increase the risk of respiratory paralysis and renal dysfunction.
Lab Tests: Aminoglycoside serum levels: Guard against in vitro inactivation of aminoglycosides by b-lactum antibiotics in patients on combination therapy.Typical Dosage for GentamicinDosage:
Adults: 2 to 5mg/kg/day; Thrice daily for a week or more
Children: 2 to 2.5mg/kg; Thrice daily.
Schedule of GentamicinHStorage Requirements for GentamicinStore below 30 degree Celsius and protect from light.Effects of Missed Dosage of GentamicinTake the missed dose as soon as noticed and if it is the time to next dose then skip the missed dose.Continue the regular schedule. Do not double the dose.Effects of Overdose of GentamicinAn overdose results in ototoxicity, nephrotoxicity, neuromuscular disorders & hypersensitivity manifestations.Treatment includes removal of drug by dialysis or by treatment with anticholinesterase like neostigmine and by administration of Ca , Prednisolone etc.
Clobetasone butyrate
About Clobetasone butyrateA new corticosteroid, Anti inflammatory.Mechanism of Action of Clobetasone butyrateClobetasone is a topical corticosteroid. It induces peptide Lipocortins which inhibit the enzyme Phospholipase A2. Phospholipase A2 is essential for the conversion of membrane phospholipids to Arachidonic acid. From this Arachidonic acid inflammatory mediators like prostaglandins, kinins, histamine, liposomal enzymes and the complement system are produced. By inhibiting Phospholipase A2 inflammatory mediators are not released. It also inhibits the migration of macrophages and leukocytes to the inflamed area by its vasoconstrictive properties. Corticosteroids also inhibit capillary production, collagen deposition and keloid (scar) formation on the inflamed area. Thus inhibiting inflammatory mediators and other actions Clobetasone are used for anti-inflammatory conditions.
Pharmacokinets of Clobetasone butyrateAbsorption: Clobetasone is absorbed through intact skin after topical administration and the amount absorbed is depending on the type of inflammation, vehicle used and the epidermal barrierOnset of Action for Clobetasone butyrateN/ADuration of Action for Clobetasone butyrateN/AHalf Life of Clobetasone butyrateN/ASide Effects of Clobetasone butyrate1.Thinning of epidermis
2.Burning
3.Itching
4.Irritation
5.Atrophy (Dermal changes)
6.Telangiectasia
7.Striae
8.Hypopigmentation
9.Contact dermatitis
10.Perioral dermatitis
11.Cataract, Glaucoma, Corneal ulcers Caused by application around eyelids and surrounding skinContra-indications of Clobetasone butyrate1.Hypersensitivity to Clobetasone and other corticosteroids
2.Acne vulgaris
3.Acne Rosacea
4.Nappy rash
5.Tuberculosis infection of the skin
6.Viral, fungal or bacterial primary infections
7.UlcersSpecial Precautions while taking Clobetasone butyrate1.Avoid application on large surface area
2.Prolonged use
3.Psoriasis
4.Avoid contact with eyes
5.Avoid occlusive dressing
6.Not used more than 5 days on the face or in the children, 6. For external use onlyPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Clobetasone butyrateSkin disorders.
1.Otitis externa
2.Eczema
3.Dermatitis
4.Photodermatitis
5.Intertrigo (Inflammation in the skin folds)
6.Seborrheic dermatitis
7.Allergy or irritant dermatitis
8.Dermatoses (secondary infected)
9.Reaction to insect bite and stings
Interactions for Clobetasone butyrateN/ATypical Dosage for Clobetasone butyrateTopical: Clobetasone 0.05 % cream is used. Apply the medicament thinly and evenly on the affected area 3- 4 times daily. Maximum drug100 g / weekSchedule of Clobetasone butyrateN/AStorage Requirements for Clobetasone butyrateStore at room temperature. Protect from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of Clobetasone butyrateApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Clobetasone butyrateGive supportive measures and symptomatic treatment.Home Delivery for Gentamicin + Clobetasone butyrate in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for gentamicin + clobetasone butyrate and other medicines and health products. Home delivery services for gentamicin + clobetasone butyrate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take gentamicin + clobetasone butyrate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for gentamicin + clobetasone butyrate before they complete the sale. You can get this information while placing the order for gentamicin + clobetasone butyrate with the pharmacy.
Gentamicin + Clobetasone butyrate is a generic medicine name and there are several brands available for it. Some of the brands for gentamicin + clobetasone butyrate might be better known than gentamicin + clobetasone butyrate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have gentamicin + clobetasone butyrate in stock, you can ask for one of the branded alternatives for gentamicin + clobetasone butyrate.
