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- Pharmacology For Neomycin + Fluocinolone acetonide + Trypsin-Chymotrypsin
Neomycin + Fluocinolone acetonide + Trypsin-Chymotrypsin Pharmacology
Neomycin + Fluocinolone acetonide + Trypsin-ChymotrypsinAbout Neomycin + Fluocinolone acetonide + Trypsin-ChymotrypsinN/AMechanism of Action of Neomycin + Fluocinolone acetonide + Trypsin-ChymotrypsinN/APharmacokinets of Neomycin + Fluocinolone acetonide + Trypsin-ChymotrypsinN/AOnset of Action for Neomycin + Fluocinolone acetonide + Trypsin-ChymotrypsinN/ADuration of Action for Neomycin + Fluocinolone acetonide + Trypsin-ChymotrypsinN/AHalf Life of Neomycin + Fluocinolone acetonide + Trypsin-ChymotrypsinN/ASide Effects of Neomycin + Fluocinolone acetonide + Trypsin-ChymotrypsinN/AContra-indications of Neomycin + Fluocinolone acetonide + Trypsin-ChymotrypsinN/ASpecial Precautions while taking Neomycin + Fluocinolone acetonide + Trypsin-ChymotrypsinN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Neomycin + Fluocinolone acetonide + Trypsin-ChymotrypsinN/AInteractions for Neomycin + Fluocinolone acetonide + Trypsin-ChymotrypsinN/ATypical Dosage for Neomycin + Fluocinolone acetonide + Trypsin-ChymotrypsinN/ASchedule of Neomycin + Fluocinolone acetonide + Trypsin-ChymotrypsinN/AStorage Requirements for Neomycin + Fluocinolone acetonide + Trypsin-ChymotrypsinN/AEffects of Missed Dosage of Neomycin + Fluocinolone acetonide + Trypsin-ChymotrypsinN/AEffects of Overdose of Neomycin + Fluocinolone acetonide + Trypsin-ChymotrypsinN/A
NeomycinAbout NeomycinAn aminoglycoside, Antibiotic, Ammonium Detoxicant.Mechanism of Action of NeomycinThis aminoglycoside cause protein synthesis inhibition by "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically Neomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.Pharmacokinets of NeomycinAbsorption- Poorly absorbed after oral administration
Distribution- Rapidly distributed in the body after oral administration. 30% bound to the plasma proteins. It crosses the placenta
Metabolism- Not metabolized
Excretion- Excreted through urine and feces (primarily as unchanged form). It also excreted through breast milk
Onset of Action for Neomycin1 to 4 hr after oral administrationDuration of Action for Neomycin8hrs after oral administrationHalf Life of NeomycinIts plasma half life is 2 to 3 hrsSide Effects of Neomycin1. Rash
3. Inflammation of the large intestine (colitis)
7. Damage to the kidneys
8. Damage to vestibular function within the ear
Contra-indications of Neomycin1. Hypersensitivity to the drug or any ingredients of it
2. Hypersensitivity to other amino glycosides
3. Intestinal obstruction
Special Precautions while taking Neomycin1. Impaired renal function
2. Neuromuscular disorder
3. Ulcerative bowel lesions
4. Extensive dermatologic conditions
5. Any other eye infection or condition
7. Cataract surgery
8. Blockage of the bowel
9. Eighth-cranial-nerve disease (loss of hearing and/or balance)
10. Kidney disease
11. Myasthenia gravis
12. Parkinson`s disease
13. Ulcers of the bowel
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Neomycin1. Coma due to liver disease
2. Preventing infection following surgery
3. Topical infections
4. Systemic infections
Interactions for NeomycinN/ATypical Dosage for NeomycinOphthalmic suspension:
1 or 2 drops every three or four hours- For eye infection
Oral (solution, tablets):
Adults and teenagers-
1 to 3 grams every six hours for five or six days- coma from liver disease
Adults and teenagers-
1 gram every hour for four hours, then 1 gram every four hours for the rest of a twenty-four hour period; or 1 gram nineteen hours before surgery, 1 gram eighteen hours before surgery, and 1 gram nine hours before surgery- cleaning the bowel before surgery.
14.7 milligrams mg/kg or 6.7 mg/ pound every four hours for three days
Adults and children-
2 to 5 drops into ear canal 3 to 4 times daily for 7 to 10 days- External ear canal infection
Schedule of NeomycinCStorage Requirements for NeomycinEye preparations store in the refrigerator protected from strong light. Do not freeze. Others are stored at <250C. Keep out of reach of children.Effects of Missed Dosage of NeomycinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of NeomycinGive symptomatic and supportive treatment. Provide haemodialysis or peritoneal dialysis to remove the drug. Treated with calcium salts or anticholinesterase to reverses neuromuscular blockade. Administer activated charcoal to prevent the further absorption of drug
Fluocinolone acetonideAbout Fluocinolone acetonideA synthetic hydrocortisone derivative, Vasoprotective ,reduce skin inflammation.Mechanism of Action of Fluocinolone acetonideFluocinolone is a topical high potency glucocorticoid.
The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits Phospholipase A2 and thus decreases the production of Prostaglandins, leukotrienes (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-?, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Fluocinolone also has immunosuppressant and antimitotic actions.
Pharmacokinets of Fluocinolone acetonideAbsorption: Fluocinolone is absorbed( <1 %) through intact skin after topical administration and the amount absorbed is depending on the type of inflammation, vehicle used, area of skin and the epidermal barrier.Onset of Action for Fluocinolone acetonideN/ADuration of Action for Fluocinolone acetonideN/AHalf Life of Fluocinolone acetonideN/ASide Effects of Fluocinolone acetonide1.Thinning of epidermis
5.Atrophy (Dermal changes)
12.Cataract,Glaucoma, Corneal ulcers caused by application around eyelids and surrounding skin
Contra-indications of Fluocinolone acetonide1. Hypersensitivity to Fluocinolone and other corticosteroids
5. Tuberculosis infection of the skin
6.Viral, fungal or bacterial primary infections
Special Precautions while taking Fluocinolone acetonide1.Avoid application on large surface area
2. Prolonged use
4.Avoid contact with eyes
5. Avoid occlusive dressing
6.Not used more than 5 days on the face or in the children
7. If irritation or hypersensitivity occurs avoid the use of medicaments.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Fluocinolone acetonide1.Psoriasis
4.Lichen simplex and planus
5.Anal and vulval pruritis
8. Dermatoses (secondary infected)
Interactions for Fluocinolone acetonideN/ATypical Dosage for Fluocinolone acetonideTopical: Fluocinolone 0.0025 %, 0.01% cream, ointment, gel or lotion is used. Clean and dry the affected area and apply the medicament thinly and evenly on the affected area for 2 - 3 times daily for 2 weeks.Schedule of Fluocinolone acetonideN/AStorage Requirements for Fluocinolone acetonideStore at room temperature. Protect from heat and moisture. Keep out of the reach of childrenEffects of Missed Dosage of Fluocinolone acetonideApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Fluocinolone acetonideGive supportive measures and symptomatic treatment.
Trypsin-ChymotrypsinAbout Trypsin-ChymotrypsinA proteolytic enzyme, Debriding agent,antiinflammatory.Mechanism of Action of Trypsin-ChymotrypsinIt is a proteolytic enzyme; its function is the digestion of proteins.It cleaves the peptide bond only at the positively charged side chains of amino acids, lysine and arginine.Pharmacokinets of Trypsin-ChymotrypsinN/AOnset of Action for Trypsin-ChymotrypsinN/ADuration of Action for Trypsin-ChymotrypsinN/AHalf Life of Trypsin-ChymotrypsinN/ASide Effects of Trypsin-Chymotrypsin1.SensitisationContra-indications of Trypsin-Chymotrypsin1.Do not spary on arterial clotSpecial Precautions while taking Trypsin-ChymotrypsinN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Trypsin-Chymotrypsin1. Debriding agent for cleaning of narcotic wounds, ulcers, sinuses and fistulas
2. Anti-inflammatory agent for the treatment of bronchial asthma, bronchitis and thrombophlebitis
Interactions for Trypsin-ChymotrypsinN/ATypical Dosage for Trypsin-ChymotrypsinN/ASchedule of Trypsin-ChymotrypsinN/AStorage Requirements for Trypsin-ChymotrypsinN/AEffects of Missed Dosage of Trypsin-ChymotrypsinN/AEffects of Overdose of Trypsin-ChymotrypsinN/A
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