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- Pharmacology For Neomycin + Bacitracin + Sulphacetamide Sodium
Neomycin + Bacitracin + Sulphacetamide Sodium Pharmacology
Neomycin + Bacitracin + Sulphacetamide Sodium
About Neomycin + Bacitracin + Sulphacetamide SodiumN/AMechanism of Action of Neomycin + Bacitracin + Sulphacetamide SodiumN/APharmacokinets of Neomycin + Bacitracin + Sulphacetamide SodiumN/AOnset of Action for Neomycin + Bacitracin + Sulphacetamide SodiumN/ADuration of Action for Neomycin + Bacitracin + Sulphacetamide SodiumN/AHalf Life of Neomycin + Bacitracin + Sulphacetamide SodiumN/ASide Effects of Neomycin + Bacitracin + Sulphacetamide SodiumN/AContra-indications of Neomycin + Bacitracin + Sulphacetamide SodiumN/ASpecial Precautions while taking Neomycin + Bacitracin + Sulphacetamide SodiumN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Neomycin + Bacitracin + Sulphacetamide SodiumN/AInteractions for Neomycin + Bacitracin + Sulphacetamide SodiumN/ATypical Dosage for Neomycin + Bacitracin + Sulphacetamide SodiumN/ASchedule of Neomycin + Bacitracin + Sulphacetamide SodiumN/AStorage Requirements for Neomycin + Bacitracin + Sulphacetamide SodiumN/AEffects of Missed Dosage of Neomycin + Bacitracin + Sulphacetamide SodiumN/AEffects of Overdose of Neomycin + Bacitracin + Sulphacetamide SodiumN/ANeomycin
About NeomycinAn aminoglycoside, Antibiotic, Ammonium Detoxicant.Mechanism of Action of NeomycinThis aminoglycoside cause protein synthesis inhibition by "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically Neomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.Pharmacokinets of NeomycinAbsorption- Poorly absorbed after oral administration
Distribution- Rapidly distributed in the body after oral administration. 30% bound to the plasma proteins. It crosses the placenta
Metabolism- Not metabolized
Excretion- Excreted through urine and feces (primarily as unchanged form). It also excreted through breast milk
Onset of Action for Neomycin1 to 4 hr after oral administrationDuration of Action for Neomycin8hrs after oral administrationHalf Life of NeomycinIts plasma half life is 2 to 3 hrsSide Effects of Neomycin1. Rash
2. Diarrhoea
3. Inflammation of the large intestine (colitis)
4. Nausea
5. Vomiting
6. Ototoxicity
7. Damage to the kidneys
8. Damage to vestibular function within the ear
Contra-indications of Neomycin1. Hypersensitivity to the drug or any ingredients of it
2. Hypersensitivity to other amino glycosides
3. Intestinal obstruction
Special Precautions while taking Neomycin1. Impaired renal function
2. Neuromuscular disorder
3. Ulcerative bowel lesions
4. Extensive dermatologic conditions
5. Any other eye infection or condition
6. Glaucoma
7. Cataract surgery
8. Blockage of the bowel
9. Eighth-cranial-nerve disease (loss of hearing and/or balance)
10. Kidney disease
11. Myasthenia gravis
12. Parkinson`s disease
13. Ulcers of the bowel
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Neomycin1. Coma due to liver disease
2. Preventing infection following surgery
3. Topical infections
4. Systemic infections
Interactions for NeomycinN/ATypical Dosage for NeomycinOphthalmic suspension:
Adults-
1 or 2 drops every three or four hours- For eye infection
Oral (solution, tablets):
Adults and teenagers-
1 to 3 grams every six hours for five or six days- coma from liver disease
Adults and teenagers-
1 gram every hour for four hours, then 1 gram every four hours for the rest of a twenty-four hour period; or 1 gram nineteen hours before surgery, 1 gram eighteen hours before surgery, and 1 gram nine hours before surgery- cleaning the bowel before surgery.
Children-
14.7 milligrams mg/kg or 6.7 mg/ pound every four hours for three days
Ear preparation:
Adults and children-
2 to 5 drops into ear canal 3 to 4 times daily for 7 to 10 days- External ear canal infection
Schedule of NeomycinCStorage Requirements for NeomycinEye preparations store in the refrigerator protected from strong light. Do not freeze. Others are stored at <250C. Keep out of reach of children.Effects of Missed Dosage of NeomycinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of NeomycinGive symptomatic and supportive treatment. Provide haemodialysis or peritoneal dialysis to remove the drug. Treated with calcium salts or anticholinesterase to reverses neuromuscular blockade. Administer activated charcoal to prevent the further absorption of drugBacitracin
About BacitracinPolypeptide antibiotic.Mechanism of Action of BacitracinBacitracin is an antibiotic produced by the strain of Bacillus subtilis. It acts by inhibiting bacterial cell wall synthesis. It is active against a variety of gram positive and a few gram negative organisms.Pharmacokinets of BacitracinN/AOnset of Action for BacitracinN/ADuration of Action for BacitracinN/AHalf Life of BacitracinN/ASide Effects of Bacitracin1.Albuminuria
2.Cylindruria
3.Azotemia
4.Rising blood levels without any increase in dosage.
5.Nausea
6.Vomiting
7.Pain at site of injection
8.Burning, Redness, Rash(topical use)
9.Nephrotoxicity (After parenteral use)
Contra-indications of BacitracinHypersensitivity to the drugSpecial Precautions while taking BacitracinHypersensitivity to other antibioticsPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for BacitracinLocally used for secondarily infected wounds, ulcers, pyodermas and other superficial skin infections.
In the eye: Superficial infections of the eye
Nasal application: Bacitracin-susceptible infections of the upper and lower respiratory tract
IM: Pneumonia and empyema caused by staphylococci in infantsInteractions for BacitracinN/ATypical Dosage for BacitracinInfants:IM use
For infants under 2.5kg: 900 units/kg/day in 2 or 3 divided doses.
For infants over 2.5kg:1000 units/kg/day in 2 or 3 divided doses.
Local use: Apply locally once or twice daily in the affected area
Schedule of BacitracinN/AStorage Requirements for BacitracinParenteral preapration: Stored at 2 - 8 degree Celsius.Other preaparations should be stored at 15 - 30 degree Celsius
Effects of Missed Dosage of BacitracinApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of BacitracinGive supportive measures and symptomatic treatment.Sulphacetamide Sodium
About Sulphacetamide SodiumSulfonamide, Anti-infective.Mechanism of Action of Sulphacetamide SodiumSulphacetamide sodium is a sterile, topical sulfonamide which exerts its bacteriostatic action by inhibiting bacterial folate synthetase enzyme and results in inhibition of bacterial folic acid synthesis. Sulfonamides are structural analogues of PABA (Para amino benzoic acid) which is an essential constituent of bacterial folic acid. It competitively inhibits the incorporation of PABA with Pteridine residue to form dihydropteroic acid which conjugates with glutamic acid and produce Dihydrofolic acid. Also being chemically similar to PABA the sulfonamides may itself incorporated to form an altered folate which is metabolically injuriousPharmacokinets of Sulphacetamide SodiumAbsorption: After instillation into the eyes only a small amount is absorbed in to the cornea.Onset of Action for Sulphacetamide SodiumN/ADuration of Action for Sulphacetamide SodiumN/AHalf Life of Sulphacetamide SodiumN/ASide Effects of Sulphacetamide Sodium1. Local irritation
2. Stinging
3. Burning
4. Blurred vision
5. Blistering
6. Peeling of the eyes
7. Eye redness
8. Swelling
9. Pain
Contra-indications of Sulphacetamide Sodium1. Hypersensitivity to Sulphacetamide and other SulphonamidesSpecial Precautions while taking Sulphacetamide Sodium1. Prolonged use
2. If irritation occurs then discontinue the use of medicaments
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: Contraindicated
Indications for Sulphacetamide Sodium1. Conjunctivitis
2. Corneal ulcers
3. Trachoma
4. Blepharitis
5. Iritis
6. Ophthalmic neonatorum
7. Injury of eyes
Interactions for Sulphacetamide SodiumN/ATypical Dosage for Sulphacetamide SodiumSulphacetamide sodium eye drops 10, 20 and 30% drops are used.
Conjunctivitis, Corneal ulcers and other superficial ocular infections: Initial dose: Instill 1 or 2 drops into the conjunctival sac of the affected eye every 2 - 3 hours for 7 - 10 days. Dosages may be gradually decreased depending on the condition responds.
Trachoma: Instill 2 drops into the conjunctival sac of the affected eye every 2 hours. Topical administration must be accompanied by systemic administration
Schedule of Sulphacetamide SodiumN/AStorage Requirements for Sulphacetamide SodiumStore at cool dry place. Do not freeze. Keep out of the reach of children.Effects of Missed Dosage of Sulphacetamide SodiumTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Sulphacetamide SodiumGive supportive measures and symptomatic treatment. The exposed eye should be irrigated with copious amounts of water for at least 15 minutes.Home Delivery for Neomycin + Bacitracin + Sulphacetamide Sodium in Your City
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