- Medicine India
- Generic Medicines
- K
- Pharmacology For Ketoconazole + Coaltar
Ketoconazole + Coaltar Pharmacology
Ketoconazole + Coaltar
About Ketoconazole + CoaltarN/AMechanism of Action of Ketoconazole + CoaltarN/APharmacokinets of Ketoconazole + CoaltarN/AOnset of Action for Ketoconazole + CoaltarN/ADuration of Action for Ketoconazole + CoaltarN/AHalf Life of Ketoconazole + CoaltarN/ASide Effects of Ketoconazole + CoaltarN/AContra-indications of Ketoconazole + CoaltarN/ASpecial Precautions while taking Ketoconazole + CoaltarN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Ketoconazole + CoaltarN/AInteractions for Ketoconazole + CoaltarN/ATypical Dosage for Ketoconazole + CoaltarN/ASchedule of Ketoconazole + CoaltarN/AStorage Requirements for Ketoconazole + CoaltarN/AEffects of Missed Dosage of Ketoconazole + CoaltarN/AEffects of Overdose of Ketoconazole + CoaltarN/AKetoconazole
About KetoconazoleImidazole derivative, A broad spectrum Antifungal.Mechanism of Action of KetoconazoleKetoconazole is fungicidal or fungistatic depending on concentrations. I t inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesis. This will alter cell membrane and its permeability. This will results in loss of intracellular components. It also inhibits biosynthesis of triglycerides and phospholipids by fungi. It also inhibits several enzymes (e.g. Oxidative and peroxidative enzymes) which are involved in detoxification process. This will leads to cellular necrosis.
Pharmacokinets of KetoconazoleAbsorption: It is absorbed only in acidic PH.Distribution: It is distributed in the body in protein bound form. Metabolism: It is metabolised to inactive metabolite in the liver. Excretion: It is excreted mainly through faeces and also through urine.
Onset of Action for KetoconazoleN/ADuration of Action for Ketoconazole1 dayHalf Life of Ketoconazole8 hour.Side Effects of Ketoconazole1.Dizziness
2.Headach
3.Nausea
4.Vomiting
5.Diarrhoea
6.Anorexia
7.Gynecomastia
8.Loss of hair
9.Libido
10.Leucopenia
11.Pruritis
12.Psychiatric problemsContra-indications of Ketoconazole1.Hypersensitivity to KetoconazoleSpecial Precautions while taking KetoconazoleHepatic dysfunctionPregnancy Related InformationContraindicated.Old Age Related InformationUse with caution.Breast Feeding Related InformationContraindicated.Children Related InformationAbove 2 years:use with caution
Below 2 years:contraindicated
NEONATES: contraindicated
Indications for Ketoconazole1.Vaginal candidiasis
2. Oral thrush
3.Candiduria
4.Histoplasmosis
5.Coccidioidomycosis
6.Paracoccidioidomycosis
8.Blastomycosis
9.Tinea pedis
10.Tinea corporis
11.Tinea cruris
12.Tinea vesicolor
13.Prostatic carcinoma
14.Dandruff
15. Seborrheic dermatitisInteractions for KetoconazoleAntacids & Histamine H2 antagonists: Increased gastric pH may inhibit ketoconazole absorption.
Isoniazid: The bioavailability of Ketoconazole may be decreased.
Rifampicin: Decreased serum levels of either drug may occur.
Oral anticoagulants: Anticoagulants response may be enhanced.
Corticosteroids: Bioavailability of corticosteroids increased and clearance may be decreased, resulting in possible toxicity.
Cyclosporine: Efficacy of cyclosporine enhanced leading to nephrotoxicity. May be used beneficially to reduce dose of cyclosporine in some patients.
Theophelline: Serum levels of theophylline may be decreased.
Alcohol: Nausea and acute facial flushing.
Typical Dosage for KetoconazoleAdult: 200 - 400 mg once daily
Prostate carcinoma: 1.2 g in 3 divided dose.
TOPICAL PREPARATIONS
For the treatment of Tinea infections apply once or twice daily on the affected part for 14 days.
Seborrheic dermatitis: apply Ketoconazole twice daily for 1 month
Dandruff: Apply for 60 seconds and rinse well. Reapply for 180 seconds. Apply twice weekly for 1 month
CHILDREN>2 years: 3.3 - 6.6 mg / kg body weight / day
TOPICAL PREPARATIONS
For the treatment of Tinea infections apply once or twice daily on the affected part for 14 days.
For Tinea pedis, apply for 1 ? month.
Seborrheic dermatitis: apply Ketoconazole twice daily for 1 month
Schedule of KetoconazoleHStorage Requirements for KetoconazoleThe drug should be stored in room temperature. Keep away from moisture and sunlight.Effects of Missed Dosage of KetoconazoleTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose and continue the regular scheduleEffects of Overdose of KetoconazoleGive supportive measures and treatment. Induce emesis or gastric lavage has to be done followed by activated charcoal and a cathartic.Coaltar
About CoaltarTopical Skin Product, Antidandruff,In seborrheic dermatitis, Anti psoriatic.Mechanism of Action of CoaltarCoaltar decreases the production of epidermal cells and inhibits mitosis through removal of oxygen in the skin. After exposure to sunlight there is an interaction between peroxides of Coaltar and sulfhydryl group of epidermis and leads to decreased epidermal proliferation. Coal tar produces antiproliferative and anti- inflammatory actions
Shampoo and soap preparations may exert their action through absorption into the epidermis and enhancement of scale removal. Coal tar preparations also possess antipruritic, antiseptic, astringent, antifungal, vasoconstrictive, and photosensitizing properties
Pharmacokinets of CoaltarN/AOnset of Action for CoaltarN/ADuration of Action for CoaltarN/AHalf Life of CoaltarN/ASide Effects of Coaltar1.Irritation
2.Folliculitis
3.Photosensitivity
Contra-indications of Coaltar1 Hypersensitivity to Coaltar
2.Acute onset psoriasis
3.Guttate psoriasis
4.Pustular psoriasis
5.Erythrodermic psoriasis
6.Inflamed or broken areas of skin
Special Precautions while taking Coaltar1 Prolonged use
2.Avoid exposure to sunlight
3.Stain skin, clothes and Hair
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Coaltar1.Psoriasis
2.Atopic dermatitis
3.Seborrheic dermatitis
4.Chronic eczemas
5.Pityriasis Alba
6.Fungal infection
7.Dandruff
Interactions for CoaltarN/ATypical Dosage for CoaltarTopical: 1-10 % cream, gel, lotion, ointment, paste or shampoo
Apply ointment or solution on affected area and exposed to sunlight daily
For coal bath use 100ml of liquid coal tar in 150-250 liters of water in a tub
Schedule of CoaltarN/AStorage Requirements for CoaltarStore in a cool, dry place away from heat and direct sunlight. Keep out of the reach of childrenEffects of Missed Dosage of CoaltarApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of CoaltarGive supportive measures and symptomatic treatmentHome Delivery for Ketoconazole + Coaltar in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ketoconazole + coaltar.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ketoconazole + coaltar and other medicines and health products. Home delivery services for ketoconazole + coaltar may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take ketoconazole + coaltar only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ketoconazole + coaltar before they complete the sale. You can get this information while placing the order for ketoconazole + coaltar with the pharmacy.
Ketoconazole + Coaltar is a generic medicine name and there are several brands available for it. Some of the brands for ketoconazole + coaltar might be better known than ketoconazole + coaltar itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ketoconazole + coaltar in stock, you can ask for one of the branded alternatives for ketoconazole + coaltar.
