Indomethacin + Paracetamol Pharmacology
Indomethacin + Paracetamol
3.Severe renal impairment
4.Suppositories in patients with proctitis and hemorrhoids.
8.Cautioned against driving, operating or activities requiring concentration
NEONATES: used only to close the patent ductus arteriosus as IV form only
8.Closure of patent ductus arteriosus in premature infants
Beta-Blockers: Antihypertensive effect may be blunted.
Cyclosporine: Nephrotoxicity of both agents may be increased.
Digoxin: Serum digoxin levels may be increased by ibuprofen and indomethacin.
Hydantoins: Serum hydantoin levels increased resulting in increased pharmacological and toxic effects.
Lithium: Serum lithium levels may be increased.
Loop diuretics: Decreased effects.
Methotrexate: Risk of methotrexate toxicity (bone marrow suppression, nephrotoxicity, stomatitis) may be increased.
Salicylates: Displaces NSAIDs from serum binding sites resulting in decreased plasma concentrations of NSAIDs and increased incidence of GI effects.
Sympathomimetics: Indomethacin coadministration may result in increased blood pressure.
Thiazide diuretics: Naproxen and indomethacin may cause decreased antihypertensive and diuretic action.
Adult: 50 - 200 mg / day in 2 - 4 divided doses.
Rheumatoid arthritis, ankylosing spondylitis and Osteoarthritis: 50 - 75 mg / day in 2 - 3 divided doses with food or antacids. Dose can be gradually increased every week until sufficient response is obtained.
Maximum dose: 200 mg / day
Gouty arthritis: 150 mg / day in 3 divided doses until pain is tolerable. Then reduce the dose and suddenly stop the drug.
Dysmenorrhoea: 75 mg / day in 3 divided doses with food or antacids.
Painful shoulder: 75 -150 mg / day in 3 - 4 divided doses for 1 - 2 week
Migraine: 50mg 3 - 4 times daily
Children: 1 mg / kg / day in divided doses.
Maximum dose: 4 mg / kg / day in divided doses.
Children below 14 years: not recommended
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
2. Abdominal distress
3. Allergic reactions
2. Renal impairment
NEONATES : Contraindicated
2. Acute gout
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
60 mg / kg body weight /day in 4 divided doses.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
Home Delivery for Indomethacin + Paracetamol in Your City
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Indomethacin + Paracetamol is a generic medicine name and there are several brands available for it. Some of the brands for indomethacin + paracetamol might be better known than indomethacin + paracetamol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have indomethacin + paracetamol in stock, you can ask for one of the branded alternatives for indomethacin + paracetamol.