Tolnaftate Pharmacology


About Tolnaftate
Thiocarbamate derivative, Antifungal.
Mechanism of Action of Tolnaftate
Tolnaftate is a reversible noncompetitive inhibitor of Squalene epoxidase enzyme of fungi. This epoxidase enzyme is useful for the conversion of Squalene to sterols. Inhibition of Squalene epoxidase enzyme will leads to a deficiency of sterols (ergosterol) and distort the hyphae and to stunt mycelial growth in susceptible organisms.
Pharmacokinets of Tolnaftate
Absorption: The absorption after topical application is negligible.
Onset of Action for Tolnaftate
Duration of Action for Tolnaftate
Half Life of Tolnaftate
Side Effects of Tolnaftate
1. Irritation
2. Redness
3. Stinging
4. Sensitisation
5. Contact dermatitis
6. Pruritis
Contra-indications of Tolnaftate
1. Hypersensitivity to Tolnaftate
2. Nail and scalp infections
3. Deep infections
Special Precautions while taking Tolnaftate
1. Avoid contact with eyes mouth vagina and nose.
2. Stop the use of medication if irritation occurs
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Below 2 years: contraindicated
Indications for Tolnaftate
1. Dermatophytosis
2. Tinea corporis (ringworm of the body)
3. Tinea cruris (ringworm of the groin; jock itch)
4. Tinea pedis (ringworm of the foot; athlete`s foot)
5. Tinea versicolor
6. Tinea barbae
Interactions for Tolnaftate
None reported.
Typical Dosage for Tolnaftate
1% cream, gel, powder and topical solution are used.
Clean and dry the affected and surrounding area. Apply the medicament with gentle massage and cover it with surgical gauze 2 - 3 times daily for 2 - 6 weeks. Wash hands before and after use.
Aerosol Powder: Spray liberally from a distance of 15 to 25 cm between toes and on feet, in shoes, socks or on affected area.
Solution: 1 - 2 drops for cover the area of hand; 2 - 3 drops cover the toes. Apply to each lesion and massage gently, then allow drying.
Schedule of Tolnaftate
Storage Requirements for Tolnaftate
Store at 15 - 25 degree C. Protect from heat and moisture. Keep out of the reach of children.
Effects of Missed Dosage of Tolnaftate
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Tolnaftate
Give supportive measures and symptomatic treatment.

Home Delivery for Tolnaftate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including tolnaftate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for tolnaftate and other medicines and health products. Home delivery services for tolnaftate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take tolnaftate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for tolnaftate before they complete the sale. You can get this information while placing the order for tolnaftate with the pharmacy.

Tolnaftate is a generic medicine name and there are several brands available for it. Some of the brands for tolnaftate might be better known than tolnaftate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tolnaftate in stock, you can ask for one of the branded alternatives for tolnaftate.