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- Pharmacology For Tolnaftate + Nystatin
Tolnaftate + Nystatin Pharmacology
Tolnaftate + Nystatin
About Tolnaftate + NystatinN/AMechanism of Action of Tolnaftate + NystatinN/APharmacokinets of Tolnaftate + NystatinN/AOnset of Action for Tolnaftate + NystatinN/ADuration of Action for Tolnaftate + NystatinN/AHalf Life of Tolnaftate + NystatinN/ASide Effects of Tolnaftate + NystatinN/AContra-indications of Tolnaftate + NystatinN/ASpecial Precautions while taking Tolnaftate + NystatinN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Tolnaftate + NystatinN/AInteractions for Tolnaftate + NystatinN/ATypical Dosage for Tolnaftate + NystatinN/ASchedule of Tolnaftate + NystatinN/AStorage Requirements for Tolnaftate + NystatinN/AEffects of Missed Dosage of Tolnaftate + NystatinN/AEffects of Overdose of Tolnaftate + NystatinN/ATolnaftate
About TolnaftateThiocarbamate derivative, Antifungal.Mechanism of Action of TolnaftateTolnaftate is a reversible noncompetitive inhibitor of Squalene epoxidase enzyme of fungi. This epoxidase enzyme is useful for the conversion of Squalene to sterols. Inhibition of Squalene epoxidase enzyme will leads to a deficiency of sterols (ergosterol) and distort the hyphae and to stunt mycelial growth in susceptible organisms.Pharmacokinets of TolnaftateAbsorption: The absorption after topical application is negligible.Onset of Action for TolnaftateN/ADuration of Action for TolnaftateN/AHalf Life of TolnaftateN/ASide Effects of Tolnaftate1. Irritation
2. Redness
3. Stinging
4. Sensitisation
5. Contact dermatitis
6. Pruritis
Contra-indications of Tolnaftate1. Hypersensitivity to Tolnaftate
2. Nail and scalp infections
3. Deep infections
Special Precautions while taking Tolnaftate1. Avoid contact with eyes mouth vagina and nose.
2. Stop the use of medication if irritation occurs
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
Below 2 years: contraindicated
Indications for Tolnaftate1. Dermatophytosis
2. Tinea corporis (ringworm of the body)
3. Tinea cruris (ringworm of the groin; jock itch)
4. Tinea pedis (ringworm of the foot; athlete`s foot)
5. Tinea versicolor
6. Tinea barbae
Interactions for TolnaftateNone reported.Typical Dosage for Tolnaftate1% cream, gel, powder and topical solution are used.
Clean and dry the affected and surrounding area. Apply the medicament with gentle massage and cover it with surgical gauze 2 - 3 times daily for 2 - 6 weeks. Wash hands before and after use.
Aerosol Powder: Spray liberally from a distance of 15 to 25 cm between toes and on feet, in shoes, socks or on affected area.
Solution: 1 - 2 drops for cover the area of hand; 2 - 3 drops cover the toes. Apply to each lesion and massage gently, then allow drying.
Schedule of TolnaftateN/AStorage Requirements for TolnaftateStore at 15 - 25 degree C. Protect from heat and moisture. Keep out of the reach of children.Effects of Missed Dosage of TolnaftateApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of TolnaftateGive supportive measures and symptomatic treatment.Nystatin
About NystatinPolyene Antifungal.Mechanism of Action of NystatinNystatin is a fungicidal as well as a fungistatic drug. It has high affinity for ergosterol present in the fungal cell membrane and bind with it and they orients in such a way that micropore channel are formed and leads to efflux of ions, amino acid, sugar and other water soluble substances through this channel and results in cell disruption.Pharmacokinets of NystatinAbsorption: It is not orally absorbed.
Excretion: It is excreted in faeces.Onset of Action for NystatinN/ADuration of Action for Nystatin1 dayHalf Life of NystatinN/ASide Effects of Nystatin1. Nausea
2. Vomiting
3. Diarrhoea
4. Pruritis
5. Bad taste
Contra-indications of Nystatin1. Hypersensitivity to NystatinSpecial Precautions while taking NystatinN/APregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Nystatin1. Oral candidiasis
2. Cutaneous candidiasis
3. Mucocutaneous candidiasis
4. Monilial vaginitis
5. Monilial diarrhoea
6. Conjunctivitis
7. Corneal candidiasis
8. Candidiasis in immunocompromised patients
Interactions for NystatinN/ATypical Dosage for NystatinAdult: 5 lac units every 8 hours in a day
Oral suspension:
Oropharyngeal candidiasis: 4 - 6 lac units four times daily
Oropharyngeal candidiasis in immunocompromised patients: 5 - 10 lac units 3 - 5 times daily
Cutaneous or Mucocutaneous candidiasis: Topical use: Apply to the affected part 2 - 3 times daily for 2 week
Vaginal candidiasis:
Vaginal use (tablets): Insert 1 lac units in to vagina 1- 2 times daily for 2 weeks
Children:
Oral suspension:
1 - 2 lac units four times daily
Schedule of NystatinHStorage Requirements for NystatinThe drug should be stored at 15 - 30 degree C.Protect away from heat and light.Effects of Missed Dosage of NystatinTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.Effects of Overdose of NystatinGive supportive measures.Home Delivery for Tolnaftate + Nystatin in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including tolnaftate + nystatin.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for tolnaftate + nystatin and other medicines and health products. Home delivery services for tolnaftate + nystatin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take tolnaftate + nystatin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for tolnaftate + nystatin before they complete the sale. You can get this information while placing the order for tolnaftate + nystatin with the pharmacy.
Tolnaftate + Nystatin is a generic medicine name and there are several brands available for it. Some of the brands for tolnaftate + nystatin might be better known than tolnaftate + nystatin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tolnaftate + nystatin in stock, you can ask for one of the branded alternatives for tolnaftate + nystatin.
