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- Pharmacology For Ciclopiroxolamine + Fluocinolone acetonide
Ciclopiroxolamine + Fluocinolone acetonide Pharmacology
Ciclopiroxolamine + Fluocinolone acetonide
About Ciclopiroxolamine + Fluocinolone acetonideN/AMechanism of Action of Ciclopiroxolamine + Fluocinolone acetonideN/APharmacokinets of Ciclopiroxolamine + Fluocinolone acetonideN/AOnset of Action for Ciclopiroxolamine + Fluocinolone acetonideN/ADuration of Action for Ciclopiroxolamine + Fluocinolone acetonideN/AHalf Life of Ciclopiroxolamine + Fluocinolone acetonideN/ASide Effects of Ciclopiroxolamine + Fluocinolone acetonideN/AContra-indications of Ciclopiroxolamine + Fluocinolone acetonideN/ASpecial Precautions while taking Ciclopiroxolamine + Fluocinolone acetonideN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Ciclopiroxolamine + Fluocinolone acetonideN/AInteractions for Ciclopiroxolamine + Fluocinolone acetonideN/ATypical Dosage for Ciclopiroxolamine + Fluocinolone acetonideN/ASchedule of Ciclopiroxolamine + Fluocinolone acetonideN/AStorage Requirements for Ciclopiroxolamine + Fluocinolone acetonideN/AEffects of Missed Dosage of Ciclopiroxolamine + Fluocinolone acetonideN/AEffects of Overdose of Ciclopiroxolamine + Fluocinolone acetonideN/ACiclopiroxolamine
About CiclopiroxolamineA synthetic antifungal agent, a hydroxypyridone derivaive.Topical Antifungal Agent.
Mechanism of Action of CiclopiroxolamineCiclopiroxolamine is a chelating agent. It forms complexes with polyvalent metal cations eg.Fe3+, Al 3+. These metal cations are essential for enzymes for exerting their cellular activities including mitochondrial electron transport and energy production. Ciclopirox alters plasma membrane of fungi and changes the internal structure of fungus. It also possesses anti-inflammatory action by inhibiting lipoxygenase and cyclo-oxygenase enzymes.Pharmacokinets of CiclopiroxolamineAbsorption: Absorption of the medicament is minimal after topical application.Onset of Action for CiclopiroxolamineN/ADuration of Action for CiclopiroxolamineN/AHalf Life of Ciclopiroxolamine1.7 hours for 1% topical solutionsSide Effects of Ciclopiroxolamine1.Burning
2.Irritation
3.Itching
4.Redness
5.Rashes
6.Dryness
7.PruritisContra-indications of Ciclopiroxolamine1.Hypersensitivity to CiclopiroxolamineSpecial Precautions while taking Ciclopiroxolamine1. Avoid the use of medicaments if irritation occurs
2. Avoid contact with eyes, mucus membrane and mouth
3. For external use only
4. Avoid use of occlusive dressings
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationUse with caution.Children Related InformationContraindicated
NEONATES: contraindicatedIndications for Ciclopiroxolamine1.Cutaneous candidiasis
2.Dermatophytosis
3.Pityriasis versicolor
4.Vulvovaginal candidiasis
Interactions for CiclopiroxolamineNo known interaction.Typical Dosage for CiclopiroxolamineTopical: Ciclopiroxolamine 1% cream. Solution and powder are used. Clean and dry the affected and surrounded area. Apply the medicament with gentle massage over the area twice daily for 1 month
:
Schedule of CiclopiroxolamineN/AStorage Requirements for CiclopiroxolamineStore at room temperature. Keep away from moisture and heat. Keep out of the reach of childrenEffects of Missed Dosage of CiclopiroxolamineApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of CiclopiroxolamineGive supportive measures and symptomatic treatment.Fluocinolone acetonide
About Fluocinolone acetonideA synthetic hydrocortisone derivative, Vasoprotective ,reduce skin inflammation.Mechanism of Action of Fluocinolone acetonideFluocinolone is a topical high potency glucocorticoid.
The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits Phospholipase A2 and thus decreases the production of Prostaglandins, leukotrienes (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-?, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Fluocinolone also has immunosuppressant and antimitotic actions.
Pharmacokinets of Fluocinolone acetonideAbsorption: Fluocinolone is absorbed( <1 %) through intact skin after topical administration and the amount absorbed is depending on the type of inflammation, vehicle used, area of skin and the epidermal barrier.Onset of Action for Fluocinolone acetonideN/ADuration of Action for Fluocinolone acetonideN/AHalf Life of Fluocinolone acetonideN/ASide Effects of Fluocinolone acetonide1.Thinning of epidermis
2.Burning
3. Itching
4.Irritation
5.Atrophy (Dermal changes)
6.Telangiectasia
7.Striae
8. Hypopigmentation
9.Contact dermatitis
10.Perioral dermatitis
11.Stinging
12.Cataract,Glaucoma, Corneal ulcers caused by application around eyelids and surrounding skin
13. Hypertrichosis
14. Dryness
15. Acne
Contra-indications of Fluocinolone acetonide1. Hypersensitivity to Fluocinolone and other corticosteroids
2.Acne vulgaris
3.Acne Rosacea
4.Nappy rash
5. Tuberculosis infection of the skin
6.Viral, fungal or bacterial primary infections
7.Ulcers
Special Precautions while taking Fluocinolone acetonide1.Avoid application on large surface area
2. Prolonged use
3.Psoriasis
4.Avoid contact with eyes
5. Avoid occlusive dressing
6.Not used more than 5 days on the face or in the children
7. If irritation or hypersensitivity occurs avoid the use of medicaments.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Fluocinolone acetonide1.Psoriasis
2.Eczema
3.Otitis externa
4.Lichen simplex and planus
5.Anal and vulval pruritis
6.Contact dermatitis
7.Seborrheic dermatitis
8. Dermatoses (secondary infected)
Interactions for Fluocinolone acetonideN/ATypical Dosage for Fluocinolone acetonideTopical: Fluocinolone 0.0025 %, 0.01% cream, ointment, gel or lotion is used. Clean and dry the affected area and apply the medicament thinly and evenly on the affected area for 2 - 3 times daily for 2 weeks.Schedule of Fluocinolone acetonideN/AStorage Requirements for Fluocinolone acetonideStore at room temperature. Protect from heat and moisture. Keep out of the reach of childrenEffects of Missed Dosage of Fluocinolone acetonideApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Fluocinolone acetonideGive supportive measures and symptomatic treatment.Home Delivery for Ciclopiroxolamine + Fluocinolone acetonide in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ciclopiroxolamine + fluocinolone acetonide and other medicines and health products. Home delivery services for ciclopiroxolamine + fluocinolone acetonide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take ciclopiroxolamine + fluocinolone acetonide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ciclopiroxolamine + fluocinolone acetonide before they complete the sale. You can get this information while placing the order for ciclopiroxolamine + fluocinolone acetonide with the pharmacy.
Ciclopiroxolamine + Fluocinolone acetonide is a generic medicine name and there are several brands available for it. Some of the brands for ciclopiroxolamine + fluocinolone acetonide might be better known than ciclopiroxolamine + fluocinolone acetonide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ciclopiroxolamine + fluocinolone acetonide in stock, you can ask for one of the branded alternatives for ciclopiroxolamine + fluocinolone acetonide.
