Oxyphenbutazone Pharmacology


About Oxyphenbutazone
NSAID ,Pyrazolidine derivative, Analgesic, Anti-inflammatory.
Mechanism of Action of Oxyphenbutazone
This peripherally acting NSAID binds to and inactivates prostaglandin H synthase and prostacyclin synthase through peroxide (H2O2) mediated deactivation i.e. by inhibiting COX1 and COX2 isoenzymes. The reduced production of prostaglandin leads to reduced inflammation of the surrounding tissues
Pharmacokinets of Oxyphenbutazone
Absorption- Readily absorbed after oral administration
Distribution- 98% bound to the plasma proteins
Metabolism- Metabolized in the liver to its metabolites by oxidation and glucoronide conjugation
Excretion- Excreted through urine
Onset of Action for Oxyphenbutazone
1 to 2 hrs
Duration of Action for Oxyphenbutazone
2 days
Half Life of Oxyphenbutazone
Side Effects of Oxyphenbutazone
1. Nausea
2. Epigastric distress
3. Aplastic anemia
4. Vomiting
5. Diarrhoea
6. Peptic ulcer
7. Depression
8. Neutropenia
9. Hypothyroidism
10. Skin rash
11. Urticaria
12. Oedema
Contra-indications of Oxyphenbutazone
1. Hypersensitivity to the drug
2. Peptic ulcer
3. Hypertension
4. Congestive heart failure
5. Impairment of liver function
6. Kidney dysfunction
7. Blood dyscrasias
8. Thyroid disease
Special Precautions while taking Oxyphenbutazone
1. Check blood counts regularly
2. Porphyria
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Indications for Oxyphenbutazone
1. Rheumatic arthritis
2. Ankylosing spondylitis
3. Gouty arthritis
4. Osteoarthritis.
6. Tendinitis
7. Sprains
8. Strains
9. Menstrual cramps
10. Bursitis
Interactions for Oxyphenbutazone
Alcohol: May impair psychomotor skills.
Oral anticoagulants, Oral antidiabetics, sulfonamides, Phenytoin: Activity, duration of effect and toxicity of these drugs may be enhanced.
Barbiturates, Promethazine, Rifampicin, Cortricosteroids & Chlorpheniramine: Reduce efficacy of oxyphenbutazone.
Typical Dosage for Oxyphenbutazone
300-600mg per day in 3 divided doses after meals
Schedule of Oxyphenbutazone
Storage Requirements for Oxyphenbutazone
Store at room temperature in a sealed container.Keep away from moisture.
Effects of Missed Dosage of Oxyphenbutazone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Oxyphenbutazone
Give symptomatic and supportive treatment.

Home Delivery for Oxyphenbutazone in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including oxyphenbutazone.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for oxyphenbutazone and other medicines and health products. Home delivery services for oxyphenbutazone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take oxyphenbutazone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for oxyphenbutazone before they complete the sale. You can get this information while placing the order for oxyphenbutazone with the pharmacy.

Oxyphenbutazone is a generic medicine name and there are several brands available for it. Some of the brands for oxyphenbutazone might be better known than oxyphenbutazone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have oxyphenbutazone in stock, you can ask for one of the branded alternatives for oxyphenbutazone.