Miconazole + Triamcinolone acetonide Pharmacology

Miconazole + Triamcinolone acetonide

About Miconazole + Triamcinolone acetonide
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Mechanism of Action of Miconazole + Triamcinolone acetonide
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Pharmacokinets of Miconazole + Triamcinolone acetonide
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Onset of Action for Miconazole + Triamcinolone acetonide
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Duration of Action for Miconazole + Triamcinolone acetonide
N/A
Half Life of Miconazole + Triamcinolone acetonide
N/A
Side Effects of Miconazole + Triamcinolone acetonide
N/A
Contra-indications of Miconazole + Triamcinolone acetonide
N/A
Special Precautions while taking Miconazole + Triamcinolone acetonide
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Miconazole + Triamcinolone acetonide
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Interactions for Miconazole + Triamcinolone acetonide
N/A
Typical Dosage for Miconazole + Triamcinolone acetonide
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Schedule of Miconazole + Triamcinolone acetonide
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Storage Requirements for Miconazole + Triamcinolone acetonide
N/A
Effects of Missed Dosage of Miconazole + Triamcinolone acetonide
N/A
Effects of Overdose of Miconazole + Triamcinolone acetonide
N/A

Miconazole

About Miconazole
An imidazole derivative, Broad spectrum Antifungal.
Mechanism of Action of Miconazole
Miconazole is fungicidal or fungistatic depending on the drug concentrations. I t inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesis
Pharmacokinets of Miconazole
Absorption: Oral absorption of Miconazole is poor. Distribution: It is distributed in the body in protein bound form Metabolism: It undergoes metabolism in the liver. Excretion: It is excreted in urine and faeces.
Onset of Action for Miconazole
N/A
Duration of Action for Miconazole
N/A
Half Life of Miconazole
1 day
Side Effects of Miconazole
1.Vulvovaginal burning
2.Burning
3.Irritation
4.Pruritis
5.Maceration
6.Dermatitis
Contra-indications of Miconazole
1.Hypersensitivity to Miconazole and other Azole antifungals
Special Precautions while taking Miconazole
1.Hepatic dysfunction
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Miconazole
1.Tinea versicolor
2.Vulvovaginal candidiasis
3.Tinea pedis
4.Tinea corporis
5.Tinea cruris
6.Otomycosis
7.Onychomycosis
8.Oral candidiasis
9.Intestinal candidiasis
10.Diaper dermatitis
Interactions for Miconazole
Benzoyl peroxide: Antibacterial synergism.
Typical Dosage for Miconazole
Adult: Topical use:
Cutaneous infections: Apply the cream twice daily on the affected part for about 1 month
Tinea versicolor: Apply the cream once daily on the affected part
Vaginal use: Insert 300 mg suppository at bed time for 3 days or Insert 100 mg suppository at bed time for 7 days

CHILDREN:
Topical use:
Cutaneous infections: Apply the cream twice daily on the affected part for about 1 month
Tinea vericolor: Apply the cream once daily on the affected part

Schedule of Miconazole
H
Storage Requirements for Miconazole
The drug should be stored at 15 - 30 degree C.
Effects of Missed Dosage of Miconazole
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Miconazole
Give supportive measures and treatment.

Triamcinolone acetonide

About Triamcinolone acetonide
A synthetic glucocorticoid, Topical anti-inflammatory(steroidal).
Mechanism of Action of Triamcinolone acetonide
The drug exerts it`s pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts more selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-a, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Triamcinolone acetonide
Absorption: Triamcinolone acetonide is absorbed after topical application. Distribution: It is distributed mainly in protein bound form. Metabolism: It is metabolized primarily in the liver. Excretion: It is excreted by the kidneys and small amount is excreted through bile also.
Onset of Action for Triamcinolone acetonide
N/A
Duration of Action for Triamcinolone acetonide
N/A
Half Life of Triamcinolone acetonide
N/A
Side Effects of Triamcinolone acetonide
1.Burning
2.Itching
3.Irritation
4.Dryness
5.Folliculitis
6.Hypertrichosis
7.Acneiform eruptions
8.Hypopigmentation
9.Dermatitis
10.Secondary infection
11.Skin atrophy
Contra-indications of Triamcinolone acetonide
Hypersensitivity to Triamcinolone acetonide
Special Precautions while taking Triamcinolone acetonide
1.Occlusive dressings
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Triamcinolone acetonide
1. Inflammations of corticosteroid-responsive dermatoses
2. Treatment of skin disorders: Dermatitis, Psoriasis
Interactions for Triamcinolone acetonide
N/A
Typical Dosage for Triamcinolone acetonide
Topical application: Apply the cream on the affected area 2-4 times daily; depending on the severity of the condition.
Schedule of Triamcinolone acetonide
N/A
Storage Requirements for Triamcinolone acetonide
Store at room temperature at a range of 15 to 30 degree C. Protect from light and moisture. Keep out of reach of children.
Effects of Missed Dosage of Triamcinolone acetonide
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Triamcinolone acetonide
Provide symptomatic treatment and supportive measures.

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