Analgin Pharmacology


About Analgin
Pyrazolone derived NSAID, Antipyretic , Anti-inflammatory and analgesic.
Mechanism of Action of Analgin
This pyrazolone group containing Non Steroidal Anti Inflammatory Drug has potent analgesic, antipyretic and moderate anti inflammatory activity. It blocks the synthesis of pyrogens. It also reduces prostaglandin D &E synthesis by cyclo oxigenase enzyme inhibition. These peripheral interactions are the cause for its analgesic and antipyretic activity. There is a small fraction of reduction in sensitivity of nerve endings due to this decreased prostaglandin synthesis. Centrally it stimulate the synthesis of beta endorphin it cause the analgesic action on visceral pain. In the muscles of biliary tract, urinary tract and in uterus it has some spasmolytic activity.
Pharmacokinets of Analgin
Absorption-rapidly absorbed after oral, intravenous, and intramuscular administration.
Distribution- widely distributed in the body
Metabolism - metabolized in the liver to its metabolites.
Excretion-Excreted via renal and non renal clearance
Onset of Action for Analgin
30 to 60 minutes.
Duration of Action for Analgin
3 to 6hrs
Half Life of Analgin
Side Effects of Analgin
1. Agranulocytosis after prolonged application 2.thrombocytopenia
3. Leucopenia
4. Proteinuria
5. Intestinal nephrites
6. Rashes
7. Urticaria
8. Asthma
9. Quincke`s edema
10. Anaphylactoid shock
11. Hypotension following rapid injection
12. Neutropenia
Contra-indications of Analgin
1. Hypersensitivity to metamizole and other pyrazolone derivatives
2. Hepatic porphyria
3. Inborn glucose-6-phosphate dehydrogenase
4. Renal or hepatic disease
5. Blood disorder.
Special Precautions while taking Analgin
1. Bronchial asthma
2. Quinckes edema
3. Chronic pulmonary infection
4. Hyper sensitivity to food and other drugs
5. Care should be taken for parenteral administration in patients with hypotension and unstable blood pressure.
Pregnancy Related Information
Old Age Related Information
Use with cvaution
Breast Feeding Related Information
Use with caution.
Children Related Information
May be used
Below 1 yrs parenteral administration should be given cautiously.
Indications for Analgin
1. Toothache
2. Headache
3. Arthralgia
4. Neuralgia
5. Myositis
6. Visceral pain
7. High fever, not responding to other drugs
8. Post operative pain
9. Pain in trauma
10. Pain in cancer
11. Colicky pain
12. Febrile state
13. Rheumatism

Interactions for Analgin
Cyclosporine : Serum levels decreased.
Typical Dosage for Analgin
Oral- 500mg to 1g every 3 to 4 times
Intramuscular - 2ml every 2 to 3 times.
Intravenous -1 to 5 ml daily by slow i.v.
Oral - For 5 to 14 yrs - 30 to 60 mg/kg tab/day.
Injection -
For 3 to 4 months - 0.1ml i.m or slow i.v. every 4 times daily.
For 1 to 4 yrs - 0.2 ml I.m or slow i.v every 4 times daily
For 5 to 7 yrs -0.4 ml I.m or slow i.v every 4 times daily
For 8 to 11 yrs - 0.5 ml I.m or slow i.v every 4 times daily
For 12 to 14 yrs -0.8 ml I.m or slow i.v every 4 times daily
Schedule of Analgin
Storage Requirements for Analgin
Stored at room temperature away from light and moisture
Effects of Missed Dosage of Analgin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Analgin
Empty the stomach. Given symptomatic and supportive treatment

Home Delivery for Analgin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including analgin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for analgin and other medicines and health products. Home delivery services for analgin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take analgin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for analgin before they complete the sale. You can get this information while placing the order for analgin with the pharmacy.

Analgin is a generic medicine name and there are several brands available for it. Some of the brands for analgin might be better known than analgin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have analgin in stock, you can ask for one of the branded alternatives for analgin.