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- Pharmacology For Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Betamethasone valerate
Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Betamethasone valerate Pharmacology
Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Betamethasone valerate
About Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Betamethasone valerateN/AMechanism of Action of Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Betamethasone valerateN/APharmacokinets of Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Betamethasone valerateN/AOnset of Action for Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Betamethasone valerateN/ADuration of Action for Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Betamethasone valerateN/AHalf Life of Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Betamethasone valerateN/ASide Effects of Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Betamethasone valerateN/AContra-indications of Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Betamethasone valerateN/ASpecial Precautions while taking Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Betamethasone valerateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Betamethasone valerateN/AInteractions for Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Betamethasone valerateN/ATypical Dosage for Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Betamethasone valerateN/ASchedule of Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Betamethasone valerateN/AStorage Requirements for Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Betamethasone valerateN/AEffects of Missed Dosage of Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Betamethasone valerateN/AEffects of Overdose of Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Betamethasone valerateN/ATolnaftate
About TolnaftateThiocarbamate derivative, Antifungal.Mechanism of Action of TolnaftateTolnaftate is a reversible noncompetitive inhibitor of Squalene epoxidase enzyme of fungi. This epoxidase enzyme is useful for the conversion of Squalene to sterols. Inhibition of Squalene epoxidase enzyme will leads to a deficiency of sterols (ergosterol) and distort the hyphae and to stunt mycelial growth in susceptible organisms.Pharmacokinets of TolnaftateAbsorption: The absorption after topical application is negligible.Onset of Action for TolnaftateN/ADuration of Action for TolnaftateN/AHalf Life of TolnaftateN/ASide Effects of Tolnaftate1. Irritation
2. Redness
3. Stinging
4. Sensitisation
5. Contact dermatitis
6. Pruritis
Contra-indications of Tolnaftate1. Hypersensitivity to Tolnaftate
2. Nail and scalp infections
3. Deep infections
Special Precautions while taking Tolnaftate1. Avoid contact with eyes mouth vagina and nose.
2. Stop the use of medication if irritation occurs
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
Below 2 years: contraindicated
Indications for Tolnaftate1. Dermatophytosis
2. Tinea corporis (ringworm of the body)
3. Tinea cruris (ringworm of the groin; jock itch)
4. Tinea pedis (ringworm of the foot; athlete`s foot)
5. Tinea versicolor
6. Tinea barbae
Interactions for TolnaftateNone reported.Typical Dosage for Tolnaftate1% cream, gel, powder and topical solution are used.
Clean and dry the affected and surrounding area. Apply the medicament with gentle massage and cover it with surgical gauze 2 - 3 times daily for 2 - 6 weeks. Wash hands before and after use.
Aerosol Powder: Spray liberally from a distance of 15 to 25 cm between toes and on feet, in shoes, socks or on affected area.
Solution: 1 - 2 drops for cover the area of hand; 2 - 3 drops cover the toes. Apply to each lesion and massage gently, then allow drying.
Schedule of TolnaftateN/AStorage Requirements for TolnaftateStore at 15 - 25 degree C. Protect from heat and moisture. Keep out of the reach of children.Effects of Missed Dosage of TolnaftateApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of TolnaftateGive supportive measures and symptomatic treatment.Gentamicin
About GentamicinAminoglycoside antibiotic.Mechanism of Action of GentamicinGentamicin exerts its bactericidal action against gram negative organisms & some of gram positive organisms by inhibiting bacterial protein synthesis. The process involves 1. Penetration of bacterial cell membrane & binding directly to the bacterial ribosome, 2. Misleading of m-RNA codon by bacterial ribosome, 3. Formation of peptide chains with wrong amino acid sequence which gets incorporated into bacterial cell membrane and alters its permeability, 4. Bacterial cell lysis. Some bacterial strains resistant to other amino glycosides are sensitive to Gentamicin.
Pharmacokinets of GentamicinAbsorption: Poorly absorbed orally
Distribution: Distributed extracellularly. CSF penetration & intraocular penetration poor.
Metabolism: Not metabolized
Excretion: Excreted mainly through urine.
Onset of Action for Gentamicin1 hour
Duration of Action for Gentamicin8 hoursHalf Life of Gentamicin2 hoursSide Effects of Gentamicin1. Vestibular damage & Ototoxicity
2. Allergic manifestations
3. Nephrotoxicity
4. Dizziness
5. Nausea
6. Vomiting
7. Seizures
Contra-indications of Gentamicin1. Hypersensitive to the drug or other amino glycosides
2. Along with chloramphenicol or tetracycline
3. Renal impairment
4. Labyrinthine disorders
Special Precautions while taking Gentamicin1. Renal impairment
2. Neuromuscular disorders
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with caution
Breast Feeding Related InformationContraindicated
Children Related InformationUse with caution
Infants : Use with caution
Indications for Gentamicin1. Infections caused by staphylococci, pseudomonas, proteous, klebsiella, enterobacter & serratia.
2. Meningitis.
3. Endocarditis
4. Urinary Tract Infections.
5. Otitis & Ocular infections.
6. Infections of burns & Skin ulcers
Interactions for GentamicinAmphotericin B, Cisplatin, Cephalosporin, Vancomycin, Methoxyflurane, Frusemide, Bumetanide: Increased nephrotoxicity.
Anaesthetics, Neuromuscular blocking agents (Tubocurarine): Risk of neuromuscular blockade and respiratory paralysis.
Penicillin, Cephalosporins, Carbenicillin, Ticarcillin: Exert antibiotic synergism, especially useful in Pseudomonas infections.
Loop diuretics: Concurrent use of these agents may increase the risk of respiratory paralysis and renal dysfunction.
Lab Tests: Aminoglycoside serum levels: Guard against in vitro inactivation of aminoglycosides by b-lactum antibiotics in patients on combination therapy.Typical Dosage for GentamicinDosage:
Adults: 2 to 5mg/kg/day; Thrice daily for a week or more
Children: 2 to 2.5mg/kg; Thrice daily.
Schedule of GentamicinHStorage Requirements for GentamicinStore below 30 degree Celsius and protect from light.Effects of Missed Dosage of GentamicinTake the missed dose as soon as noticed and if it is the time to next dose then skip the missed dose.Continue the regular schedule. Do not double the dose.Effects of Overdose of GentamicinAn overdose results in ototoxicity, nephrotoxicity, neuromuscular disorders & hypersensitivity manifestations.Treatment includes removal of drug by dialysis or by treatment with anticholinesterase like neostigmine and by administration of Ca , Prednisolone etc.
Iodochlorohydroxyquinoline
About IodochlorohydroxyquinolineA hydroxyquinoline derivative, Antiprotozoal, amebicide.Mechanism of Action of IodochlorohydroxyquinolineN/APharmacokinets of IodochlorohydroxyquinolineN/AOnset of Action for IodochlorohydroxyquinolineN/ADuration of Action for IodochlorohydroxyquinolineN/AHalf Life of IodochlorohydroxyquinolineN/ASide Effects of IodochlorohydroxyquinolineN/AContra-indications of IodochlorohydroxyquinolineN/ASpecial Precautions while taking IodochlorohydroxyquinolineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for IodochlorohydroxyquinolineN/AInteractions for IodochlorohydroxyquinolineN/ATypical Dosage for IodochlorohydroxyquinolineN/ASchedule of IodochlorohydroxyquinolineN/AStorage Requirements for IodochlorohydroxyquinolineN/AEffects of Missed Dosage of IodochlorohydroxyquinolineN/AEffects of Overdose of IodochlorohydroxyquinolineN/ABetamethasone valerate
About Betamethasone valerateIt is a topical steroid
Mechanism of Action of Betamethasone valerateThe drug exerts it`s pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemotaxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Betamethasone valerateAbsorption: It is absorbed in to the systemic circulation and the amount is depending on the potency, amount applied and the nature of the skin at the site of application. Absorption increases at the site of skin damage, inflammation or occlusion.
Onset of Action for Betamethasone valerateN/ADuration of Action for Betamethasone valerateN/AHalf Life of Betamethasone valerateN/ASide Effects of Betamethasone valerate1.Thinning of the skin
2.Loss of elasticity
3.Increased hair growth
4.Acne at the site of application
5.Mild depigmentation
6.Rosacea
Contra-indications of Betamethasone valerate1.Untreated bacterial, virus or fungal infections
2.Acne vulgaris,
3.Peri-oral dermatitis,
4.Scabies,
5.Leg ulcers,
6.Tuberculosis of the skin,
7.Varicose ulcers,
8.Skin lesions caused by infections with ring worm,. fungi (e.g. Candida, Tinea) or bacteria (e.g. impetigo)
9.Hypersensitivity to Betamethasone and other corticosteroids.
10.Discoid lupus Erythematosus
Special Precautions while taking Betamethasone valerate1.Avoid contact with eyes
2.For external use only
3.Prolonged use
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Betamethasone valerate1.Psoriasis,
2.Eczema,
3.Otitis externa,
4.Lichen simplex and planus,
5.Anal and vulval Pruritis,
6.Seborrheic dermatitis,
7.Contact dermatitis,
8.Steroidal responsive dermatoses of the scalp
Interactions for Betamethasone valerateN/ATypical Dosage for Betamethasone valerateTopical:
Betamethasone Valerate: Apply to the affected area as thin film 1 - 4 times daily depending upon the severity, skin and rate of absorption.
Dermatoses of the scalp: (Betamethasone Valerate 0.12%): Small amount of foam is applied in to the scalp with gentle massage 2 times a day for up to 2 weeks.
Schedule of Betamethasone valerateN/AStorage Requirements for Betamethasone valerateStore at room temperature in a well closed; light resistant container. Protect from excess heat and moisture. Keep out of reach of children.Effects of Missed Dosage of Betamethasone valerateApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Betamethasone valerateProvide symptomatic treatment and supportive measures.Home Delivery for Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Betamethasone valerate in Your City
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Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Betamethasone valerate is a generic medicine name and there are several brands available for it. Some of the brands for tolnaftate + gentamicin + iodochlorohydroxyquinoline + betamethasone valerate might be better known than tolnaftate + gentamicin + iodochlorohydroxyquinoline + betamethasone valerate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tolnaftate + gentamicin + iodochlorohydroxyquinoline + betamethasone valerate in stock, you can ask for one of the branded alternatives for tolnaftate + gentamicin + iodochlorohydroxyquinoline + betamethasone valerate.
