Analgin + Paracetamol + Codeine Pharmacology

Analgin + Paracetamol + Codeine

About Analgin + Paracetamol + Codeine
N/A
Mechanism of Action of Analgin + Paracetamol + Codeine
N/A
Pharmacokinets of Analgin + Paracetamol + Codeine
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Onset of Action for Analgin + Paracetamol + Codeine
N/A
Duration of Action for Analgin + Paracetamol + Codeine
N/A
Half Life of Analgin + Paracetamol + Codeine
N/A
Side Effects of Analgin + Paracetamol + Codeine
N/A
Contra-indications of Analgin + Paracetamol + Codeine
N/A
Special Precautions while taking Analgin + Paracetamol + Codeine
N/A
Pregnancy Related Information
Contraindicated; Since Codeine is contraindicated in pregnancy.
Old Age Related Information
N/A
Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Analgin + Paracetamol + Codeine
1.Fever
2.Pain
Interactions for Analgin + Paracetamol + Codeine
N/A
Typical Dosage for Analgin + Paracetamol + Codeine
1 tablet to be taken 3 - 4 times daily.
Schedule of Analgin + Paracetamol + Codeine
N/A
Storage Requirements for Analgin + Paracetamol + Codeine
N/A
Effects of Missed Dosage of Analgin + Paracetamol + Codeine
N/A
Effects of Overdose of Analgin + Paracetamol + Codeine
N/A

Analgin

About Analgin
Pyrazolone derived NSAID, Antipyretic , Anti-inflammatory and analgesic.
Mechanism of Action of Analgin
This pyrazolone group containing Non Steroidal Anti Inflammatory Drug has potent analgesic, antipyretic and moderate anti inflammatory activity. It blocks the synthesis of pyrogens. It also reduces prostaglandin D &E synthesis by cyclo oxigenase enzyme inhibition. These peripheral interactions are the cause for its analgesic and antipyretic activity. There is a small fraction of reduction in sensitivity of nerve endings due to this decreased prostaglandin synthesis. Centrally it stimulate the synthesis of beta endorphin it cause the analgesic action on visceral pain. In the muscles of biliary tract, urinary tract and in uterus it has some spasmolytic activity.
Pharmacokinets of Analgin
Absorption-rapidly absorbed after oral, intravenous, and intramuscular administration.
Distribution- widely distributed in the body
Metabolism - metabolized in the liver to its metabolites.
Excretion-Excreted via renal and non renal clearance
Onset of Action for Analgin
30 to 60 minutes.
Duration of Action for Analgin
3 to 6hrs
Half Life of Analgin
N/A
Side Effects of Analgin
1. Agranulocytosis after prolonged application 2.thrombocytopenia
3. Leucopenia
4. Proteinuria
5. Intestinal nephrites
6. Rashes
7. Urticaria
8. Asthma
9. Quincke`s edema
10. Anaphylactoid shock
11. Hypotension following rapid injection
12. Neutropenia
Contra-indications of Analgin
1. Hypersensitivity to metamizole and other pyrazolone derivatives
2. Hepatic porphyria
3. Inborn glucose-6-phosphate dehydrogenase
4. Renal or hepatic disease
5. Blood disorder.
Special Precautions while taking Analgin
1. Bronchial asthma
2. Quinckes edema
3. Chronic pulmonary infection
4. Hyper sensitivity to food and other drugs
5. Care should be taken for parenteral administration in patients with hypotension and unstable blood pressure.
Pregnancy Related Information
N/A
Old Age Related Information
Use with cvaution
Breast Feeding Related Information
Use with caution.
Children Related Information
May be used
Below 1 yrs parenteral administration should be given cautiously.
Indications for Analgin
1. Toothache
2. Headache
3. Arthralgia
4. Neuralgia
5. Myositis
6. Visceral pain
7. High fever, not responding to other drugs
8. Post operative pain
9. Pain in trauma
10. Pain in cancer
11. Colicky pain
12. Febrile state
13. Rheumatism

Interactions for Analgin
Cyclosporine : Serum levels decreased.
Typical Dosage for Analgin
Adults-
Oral- 500mg to 1g every 3 to 4 times
Intramuscular - 2ml every 2 to 3 times.
Intravenous -1 to 5 ml daily by slow i.v.
Children-
Oral - For 5 to 14 yrs - 30 to 60 mg/kg tab/day.
Injection -
For 3 to 4 months - 0.1ml i.m or slow i.v. every 4 times daily.
For 1 to 4 yrs - 0.2 ml I.m or slow i.v every 4 times daily
For 5 to 7 yrs -0.4 ml I.m or slow i.v every 4 times daily
For 8 to 11 yrs - 0.5 ml I.m or slow i.v every 4 times daily
For 12 to 14 yrs -0.8 ml I.m or slow i.v every 4 times daily
Schedule of Analgin
H
Storage Requirements for Analgin
Stored at room temperature away from light and moisture
Effects of Missed Dosage of Analgin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Analgin
Empty the stomach. Given symptomatic and supportive treatment

Paracetamol

About Paracetamol
Acetanilide derivative, Non narcotic Analgesic,Antipyretic.
Mechanism of Action of Paracetamol
Paracetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of Paracetamol
Absorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol
30 - 60 minutes
Duration of Action for Paracetamol
6 hours
Half Life of Paracetamol
1-4 hours
Side Effects of Paracetamol
1. Nausea
2. Abdominal distress
3. Allergic reactions
4. Rash
Contra-indications of Paracetamol
1. Hypersensitivity to Paracetamol
Special Precautions while taking Paracetamol
1. Hepatic impairment
2. Renal impairment
3. Hypertension
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES : Contraindicated
Indications for Paracetamol
1. To relieve pain and fever
2. Acute gout
3. Migraine
Interactions for Paracetamol
Cholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.
Typical Dosage for Paracetamol
Adult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Schedule of Paracetamol
H
Storage Requirements for Paracetamol
Store at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.
Effects of Missed Dosage of Paracetamol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Paracetamol
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.

Codeine

About Codeine
An opiate, methylmorphine , Narcotic analgesic, antitussive, and antidiarrheal.
Mechanism of Action of Codeine
Codeine exerts it`s action through opioid receptors and posses antitussive properties. It selectively and directly acts on cough centre and suppresses cough. It also posses analgesic action due to it`s agonistic action on opioid receptors.
Pharmacokinets of Codeine
Absorption: Well absorbed after oral and parenteral administration. Distribution: Widely distributed in the body; it crosses placenta and also enters in to the breast milk. Metabolism: Metabolized in the liver by demethylation and glucuronide conjugation, Excretion: Excreted mainly in the urine as nor codeine and free and conjugated morphine.
Onset of Action for Codeine
Oral: 30 to 45 minutes
I.V.: Rapid
I.M.: 10 to 30 minutes
S.C.: 10 to 30 minutes
Duration of Action for Codeine
Oral: 4 to 6 hours
I.V.: 4 to 6 hours
I.M.: 4 to 6 hours
S.C.: 4 to 6 hours
Half Life of Codeine
N/A
Side Effects of Codeine
1. Constipation
2. Nausea
3. Vomiting
4. Drymouth
5. Respiratory depression
6. Hypotension
7. Bradycardia
8. Dizziness
9. Sedation
10. Euphoria
11. Urine retention
12. Flushing
13. Pruritus
14. Diaphoresis
15. Physical dependence.
Contra-indications of Codeine
1. Hypersensitivity to the drug
2. Bronchial asthma
3. Increased intracranial pressure
4. Respiratory depression
5. Paralytic ileus
6. Head injury
7. Alcoholism
8. Diverticulitis
9. Following bowel surgery.
Special Precautions while taking Codeine
1. Renal impairment
2. Hepatic impairment
3. Increased CSF pressure
4. Hypothyroidism
5. Addison`s disease
6. COPD
7. In deliberate individuals
8. Prostatic hypertrophy
9. Epilepsy
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Codeine
1. Nonproductive cough
2. Mild to moderate pain.
Interactions for Codeine
N/A
Typical Dosage for Codeine
Adults:
Oral:
Nonproductive cough:10 to 20mg 4 times daily;Maximum dose: 120mg/day
Oral, S.C., I.M.:
Mild to moderate pain:15 to 60mg Orally, S.C., or I.M.;4 to 6 times daily as required by the patient.

Children:
Oral:
Nonproductive cough:
Over 12 years: 10 to 20mg 4 times daily
Age 6 to 12: 5 to 10mg 4 times daily;Maximum dose: 60mg/day
Age 2 to 6: 1mg/kg/day as four equally divided doses and do not exceed 30mg in 24 hours.
Oral, S.C., I.M.:
Mild to moderate pain:0.5mg/kg orally every 4 to 6 hours or 0.5mg/kg S.C. or I.M.
Schedule of Codeine
H
Storage Requirements for Codeine
Store at controlled room temperature at a range of 15 to 30 degree C and protects from light.
Effects of Missed Dosage of Codeine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Codeine
Establish adequate respiratory exchange via a patent airway and ventilation as needed. Administer opioid antagonist Naloxone to reverse respiratory depression use repeatedly as required. (Naloxone shouldn`t be administered unless patient has clinically significant respiratory or cardiovascular depression.). If patient shows signs and symptoms within 2 hours of ingestion empty the stomach by gastric lavage and induced emesis. Reduce absorption by administration of activated charcoal. Closely monitor vital parameters and correct fluid and electrolyte balance. Provide symptomatic and supportive treatment.

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Analgin + Paracetamol + Codeine is a generic medicine name and there are several brands available for it. Some of the brands for analgin + paracetamol + codeine might be better known than analgin + paracetamol + codeine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have analgin + paracetamol + codeine in stock, you can ask for one of the branded alternatives for analgin + paracetamol + codeine.