Tolnaftate + Iodochlorohydroxyquinoline+ Gentamicin + Beclomethasone dipropionate Pharmacology

Tolnaftate + Iodochlorohydroxyquinoline+ Gentamicin + Beclomethasone dipropionate

About Tolnaftate + Iodochlorohydroxyquinoline+ Gentamicin + Beclomethasone dipropionate
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Mechanism of Action of Tolnaftate + Iodochlorohydroxyquinoline+ Gentamicin + Beclomethasone dipropionate
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Pharmacokinets of Tolnaftate + Iodochlorohydroxyquinoline+ Gentamicin + Beclomethasone dipropionate
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Onset of Action for Tolnaftate + Iodochlorohydroxyquinoline+ Gentamicin + Beclomethasone dipropionate
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Duration of Action for Tolnaftate + Iodochlorohydroxyquinoline+ Gentamicin + Beclomethasone dipropionate
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Half Life of Tolnaftate + Iodochlorohydroxyquinoline+ Gentamicin + Beclomethasone dipropionate
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Side Effects of Tolnaftate + Iodochlorohydroxyquinoline+ Gentamicin + Beclomethasone dipropionate
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Contra-indications of Tolnaftate + Iodochlorohydroxyquinoline+ Gentamicin + Beclomethasone dipropionate
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Special Precautions while taking Tolnaftate + Iodochlorohydroxyquinoline+ Gentamicin + Beclomethasone dipropionate
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Tolnaftate + Iodochlorohydroxyquinoline+ Gentamicin + Beclomethasone dipropionate
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Interactions for Tolnaftate + Iodochlorohydroxyquinoline+ Gentamicin + Beclomethasone dipropionate
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Typical Dosage for Tolnaftate + Iodochlorohydroxyquinoline+ Gentamicin + Beclomethasone dipropionate
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Schedule of Tolnaftate + Iodochlorohydroxyquinoline+ Gentamicin + Beclomethasone dipropionate
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Storage Requirements for Tolnaftate + Iodochlorohydroxyquinoline+ Gentamicin + Beclomethasone dipropionate
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Effects of Missed Dosage of Tolnaftate + Iodochlorohydroxyquinoline+ Gentamicin + Beclomethasone dipropionate
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Effects of Overdose of Tolnaftate + Iodochlorohydroxyquinoline+ Gentamicin + Beclomethasone dipropionate
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Tolnaftate

About Tolnaftate
Thiocarbamate derivative, Antifungal.
Mechanism of Action of Tolnaftate
Tolnaftate is a reversible noncompetitive inhibitor of Squalene epoxidase enzyme of fungi. This epoxidase enzyme is useful for the conversion of Squalene to sterols. Inhibition of Squalene epoxidase enzyme will leads to a deficiency of sterols (ergosterol) and distort the hyphae and to stunt mycelial growth in susceptible organisms.
Pharmacokinets of Tolnaftate
Absorption: The absorption after topical application is negligible.
Onset of Action for Tolnaftate
N/A
Duration of Action for Tolnaftate
N/A
Half Life of Tolnaftate
N/A
Side Effects of Tolnaftate
1. Irritation
2. Redness
3. Stinging
4. Sensitisation
5. Contact dermatitis
6. Pruritis
Contra-indications of Tolnaftate
1. Hypersensitivity to Tolnaftate
2. Nail and scalp infections
3. Deep infections
Special Precautions while taking Tolnaftate
1. Avoid contact with eyes mouth vagina and nose.
2. Stop the use of medication if irritation occurs
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Below 2 years: contraindicated
Indications for Tolnaftate
1. Dermatophytosis
2. Tinea corporis (ringworm of the body)
3. Tinea cruris (ringworm of the groin; jock itch)
4. Tinea pedis (ringworm of the foot; athlete`s foot)
5. Tinea versicolor
6. Tinea barbae
Interactions for Tolnaftate
None reported.
Typical Dosage for Tolnaftate
1% cream, gel, powder and topical solution are used.
Clean and dry the affected and surrounding area. Apply the medicament with gentle massage and cover it with surgical gauze 2 - 3 times daily for 2 - 6 weeks. Wash hands before and after use.
Aerosol Powder: Spray liberally from a distance of 15 to 25 cm between toes and on feet, in shoes, socks or on affected area.
Solution: 1 - 2 drops for cover the area of hand; 2 - 3 drops cover the toes. Apply to each lesion and massage gently, then allow drying.
Schedule of Tolnaftate
N/A
Storage Requirements for Tolnaftate
Store at 15 - 25 degree C. Protect from heat and moisture. Keep out of the reach of children.
Effects of Missed Dosage of Tolnaftate
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Tolnaftate
Give supportive measures and symptomatic treatment.

Iodochlorohydroxyquinoline

About Iodochlorohydroxyquinoline
A hydroxyquinoline derivative, Antiprotozoal, amebicide.
Mechanism of Action of Iodochlorohydroxyquinoline
N/A
Pharmacokinets of Iodochlorohydroxyquinoline
N/A
Onset of Action for Iodochlorohydroxyquinoline
N/A
Duration of Action for Iodochlorohydroxyquinoline
N/A
Half Life of Iodochlorohydroxyquinoline
N/A
Side Effects of Iodochlorohydroxyquinoline
N/A
Contra-indications of Iodochlorohydroxyquinoline
N/A
Special Precautions while taking Iodochlorohydroxyquinoline
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Iodochlorohydroxyquinoline
N/A
Interactions for Iodochlorohydroxyquinoline
N/A
Typical Dosage for Iodochlorohydroxyquinoline
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Schedule of Iodochlorohydroxyquinoline
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Storage Requirements for Iodochlorohydroxyquinoline
N/A
Effects of Missed Dosage of Iodochlorohydroxyquinoline
N/A
Effects of Overdose of Iodochlorohydroxyquinoline
N/A

Gentamicin

About Gentamicin
Aminoglycoside antibiotic.
Mechanism of Action of Gentamicin
Gentamicin exerts its bactericidal action against gram negative organisms & some of gram positive organisms by inhibiting bacterial protein synthesis. The process involves 1. Penetration of bacterial cell membrane & binding directly to the bacterial ribosome, 2. Misleading of m-RNA codon by bacterial ribosome, 3. Formation of peptide chains with wrong amino acid sequence which gets incorporated into bacterial cell membrane and alters its permeability, 4. Bacterial cell lysis. Some bacterial strains resistant to other amino glycosides are sensitive to Gentamicin.
Pharmacokinets of Gentamicin
Absorption: Poorly absorbed orally
Distribution: Distributed extracellularly. CSF penetration & intraocular penetration poor.
Metabolism: Not metabolized
Excretion: Excreted mainly through urine.

Onset of Action for Gentamicin
1 hour
Duration of Action for Gentamicin
8 hours
Half Life of Gentamicin
2 hours
Side Effects of Gentamicin
1. Vestibular damage & Ototoxicity
2. Allergic manifestations
3. Nephrotoxicity
4. Dizziness
5. Nausea
6. Vomiting
7. Seizures
Contra-indications of Gentamicin
1. Hypersensitive to the drug or other amino glycosides
2. Along with chloramphenicol or tetracycline
3. Renal impairment
4. Labyrinthine disorders

Special Precautions while taking Gentamicin
1. Renal impairment
2. Neuromuscular disorders
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Infants : Use with caution
Indications for Gentamicin
1. Infections caused by staphylococci, pseudomonas, proteous, klebsiella, enterobacter & serratia.
2. Meningitis.
3. Endocarditis
4. Urinary Tract Infections.
5. Otitis & Ocular infections.
6. Infections of burns & Skin ulcers
Interactions for Gentamicin
Amphotericin B, Cisplatin, Cephalosporin, Vancomycin, Methoxyflurane, Frusemide, Bumetanide: Increased nephrotoxicity.
Anaesthetics, Neuromuscular blocking agents (Tubocurarine): Risk of neuromuscular blockade and respiratory paralysis.
Penicillin, Cephalosporins, Carbenicillin, Ticarcillin: Exert antibiotic synergism, especially useful in Pseudomonas infections.
Loop diuretics: Concurrent use of these agents may increase the risk of respiratory paralysis and renal dysfunction.
Lab Tests: Aminoglycoside serum levels: Guard against in vitro inactivation of aminoglycosides by b-lactum antibiotics in patients on combination therapy.
Typical Dosage for Gentamicin
Dosage:
Adults: 2 to 5mg/kg/day; Thrice daily for a week or more
Children: 2 to 2.5mg/kg; Thrice daily.
Schedule of Gentamicin
H
Storage Requirements for Gentamicin
Store below 30 degree Celsius and protect from light.
Effects of Missed Dosage of Gentamicin
Take the missed dose as soon as noticed and if it is the time to next dose then skip the missed dose.Continue the regular schedule. Do not double the dose.
Effects of Overdose of Gentamicin
An overdose results in ototoxicity, nephrotoxicity, neuromuscular disorders & hypersensitivity manifestations.Treatment includes removal of drug by dialysis or by treatment with anticholinesterase like neostigmine and by administration of Ca , Prednisolone etc.

Beclomethasone dipropionate

About Beclomethasone dipropionate
Potent glucocorticoid, Potent anti-inflammatory agent in respiratory tract and nasal passages.
Mechanism of Action of Beclomethasone dipropionate
Mechanism of action: The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits Phospholipase A2 and thus decreases the production of Prostaglandins, leukotrienes (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.


Pharmacokinets of Beclomethasone dipropionate
Absorption: It enters in to the systemic circulation after topical administration.
Onset of Action for Beclomethasone dipropionate
N/A
Duration of Action for Beclomethasone dipropionate
N/A
Half Life of Beclomethasone dipropionate
N/A
Side Effects of Beclomethasone dipropionate
1.Thinning of the skin
2.Loss of elasticity
3.Increased hair growth
4.Acne at the site of application
5.Mild depigmentation
6.Rosacea
Contra-indications of Beclomethasone dipropionate
1.Hypersensitivity to Beclomethasone
2.Untreated bacterial virus or fungal infections
3.Acne vulgaris
4.Peri-oral dermatitis
5.Tuberculosis of the skin
6.Varicose ulcers
7.Skin lesions caused by infections with herpes simplex vaccinia or varicella viruses. fungi (e.g. Candida Tinea) or bacteria (e.g. impetigo)
8.Discoid lupus Erythematosus
Special Precautions while taking Beclomethasone dipropionate
1.Avoid contact with eyes
2.For external use only
3.Prolonged use
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Beclomethasone dipropionate
1.Eczema
2.Psoriasis
3.Contact dermatitis
4.Anal and vulval Pruritis
5.Inflammation of the skin
Interactions for Beclomethasone dipropionate
There are no known drug interactions with topical betamethasone dipropionate.
Typical Dosage for Beclomethasone dipropionate
Topical: Apply 0.025 %w/w cream as thin film 1 - 2times daily on to the affected area
Schedule of Beclomethasone dipropionate
H
Storage Requirements for Beclomethasone dipropionate
Store below 25 degree C in a tightly closed container. Keep out of the reach of children
Effects of Missed Dosage of Beclomethasone dipropionate
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Beclomethasone dipropionate
Give supportive measures and symptomatic treatment.

Home Delivery for Tolnaftate + Iodochlorohydroxyquinoline+ Gentamicin + Beclomethasone dipropionate in Your City

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