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- Pharmacology For Clotrimazole + Ciprofloxacin + Fluocinolone acetonide
Clotrimazole + Ciprofloxacin + Fluocinolone acetonide Pharmacology
Clotrimazole + Ciprofloxacin + Fluocinolone acetonide
About Clotrimazole + Ciprofloxacin + Fluocinolone acetonideN/AMechanism of Action of Clotrimazole + Ciprofloxacin + Fluocinolone acetonideN/APharmacokinets of Clotrimazole + Ciprofloxacin + Fluocinolone acetonideN/AOnset of Action for Clotrimazole + Ciprofloxacin + Fluocinolone acetonideN/ADuration of Action for Clotrimazole + Ciprofloxacin + Fluocinolone acetonideN/AHalf Life of Clotrimazole + Ciprofloxacin + Fluocinolone acetonideN/ASide Effects of Clotrimazole + Ciprofloxacin + Fluocinolone acetonideN/AContra-indications of Clotrimazole + Ciprofloxacin + Fluocinolone acetonideN/ASpecial Precautions while taking Clotrimazole + Ciprofloxacin + Fluocinolone acetonideN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationCiprofloxacin is contraindicated in breast feeding, so the combination generic is contraindicated in breast feeding mother.Children Related InformationN/AIndications for Clotrimazole + Ciprofloxacin + Fluocinolone acetonideIt is a combination of antifungal Clotrimazole, antibacterial Ciprofloxacin and anti-inflammatory Fluocinolone.
1.Skin disorders
Interactions for Clotrimazole + Ciprofloxacin + Fluocinolone acetonideN/ATypical Dosage for Clotrimazole + Ciprofloxacin + Fluocinolone acetonideApply the medicament to the affected area twice daily.Schedule of Clotrimazole + Ciprofloxacin + Fluocinolone acetonideN/AStorage Requirements for Clotrimazole + Ciprofloxacin + Fluocinolone acetonideN/AEffects of Missed Dosage of Clotrimazole + Ciprofloxacin + Fluocinolone acetonideN/AEffects of Overdose of Clotrimazole + Ciprofloxacin + Fluocinolone acetonideN/AClotrimazole
About ClotrimazoleA broad-spectrum antifungal antibiotic, imidazole derivative, Oral Nonabsorbed Antifungal Agent.Mechanism of Action of ClotrimazoleClotrimazole is fungicidal or fungistatic depending on the drug concentrations. It inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesis which is an essential constituent of cell membrane. Inhibition of ergosterol synthesis will alter the membrane permeability of the susceptible fungus and kill or inhibit them.Pharmacokinets of ClotrimazoleAbsorption: Absorption is minimal after topical administration.Onset of Action for ClotrimazoleN/ADuration of Action for Clotrimazole3 hoursHalf Life of ClotrimazoleN/ASide Effects of Clotrimazole1.Stinging
2.Erythema
3.Burning
4.Pruritis
5.Vesication
6.Desquamation
7.Urticaria
8.Burning
9.Peeling
10.Irritation
Contra-indications of ClotrimazoleHypersensitivity to ClotrimazoleSpecial Precautions while taking Clotrimazole1.Avoid contact with eyes, nose and mouth.
2.Do not wear occlusive dress over the medicament.
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationUse with caution.Children Related InformationUse with caution.
NEONATES: contraindicatedIndications for Clotrimazole1.Tinea pedis
2.Tinea cruris
3.Tinea versicolor
4.Tinea corporis
5.Cutaneous candidiasis
6.Vulvovaginal candidiasis
Interactions for ClotrimazolePolyene Antibiotics : Antagonises effects of polyene antibiotics.Typical Dosage for ClotrimazoleTopical: Clotrimazole cream, lotion and solution 1 % is used.
Clean and dry the affected area and apply the medicament with gentle massage 2 -3 times daily for 2 - 4 weeks.
Vaginal candidiasis: Insert 1 applicator full (vaginal cream 1%) intravaginally at night for 1 -2 weeks.
Vaginal tablets 100. 200 and 500mg tablet is available.
Vulvovaginal candidiasis: Insert 100mg tablet intravaginally at bed time for 7 consecutive days or 200 mg tablet for 3 consecutive days or 500 mg tablet for 1 day at night.
Oral lozenge 10 mg is available
Oropharyngeal candidiasis: 1 lozenge orally 5 times daily for 2 weeks
Prophylaxis of Oropharyngeal candidiasis: 1 lozenge is used 3 times daily
Gel: Insert with an applicator intravaginally at night for 1 - 2 weeks.
Powder (1% w/ w): dusted over the body parts as required
Schedule of ClotrimazoleHStorage Requirements for ClotrimazoleStore at room temperature (15 - 25 degree C). Protect from heat and moisture. Keep out of the reach of childrenEffects of Missed Dosage of ClotrimazoleApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ClotrimazoleGive supportive measures and symptomatic treatment.Ciprofloxacin
About CiprofloxacinIt is a broad spectrum fluoroquinolone with activity against Pseudomonas aeruginosa.
EYE DROPS: It is a fluroquinolone antibacterial having broad spectrum of activity.Mechanism of Action of CiprofloxacinCiprofloxacin is a bacteriostatic at low concentration and bactericidal at high concentration. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Ciprofloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.Pharmacokinets of CiprofloxacinAbsorption: They are adequately absorbed after oral administration. Distribution: It is distributed widely in the body. Metabolism: It undergoes hepatic metabolism. Excretion: Drug is excreted mainly through urine.
Onset of Action for CiprofloxacinWithin 1hr.
Duration of Action for Ciprofloxacin8-12 hours.
Half Life of Ciprofloxacin3 - 5 hourSide Effects of Ciprofloxacin1.Nausea
2.Vomiting
3.Diarrhoea
4.Abdominal discomfort
5.Restlessness
6.Dizziness
7.Drowsiness
8.Arthralgia
9.Rash
10.Confusion
11.Insomnia
12.Anorexia
13.Bad taste
14.Headache
15.Photosensitivity
Contra-indications of CiprofloxacinHypersensitivity to Ciprofloxacin and other FluoroquinolonesSpecial Precautions while taking Ciprofloxacin1.Hepatic impairment
2.Renal impairment
3.Epilepsy
4.Dehydration
5.Caution while driving the vehicle or operating machine or involved in any hazardous activities.
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES: contraindicatedIndications for Ciprofloxacin1.Urinary tract infection
2.Respiratory tract infection
3.Bone and joint infections,
4.Infectious diarrhoea
5.Gonorrhoea
6.ENT infections
7.Skin and soft tissue infections
8.Typhoid fever
9.Intra-abdominal infections
10.Prostatitis
11. Sinusitis
12.Chancroid
13.Gynaecological infections
14.TularemiaInteractions for CiprofloxacinAntacids (aluminium/magnesium hydroxide), Iron salts, Zinc salts.: Absorption of ciprofloxacin is decreased.
Antineoplastic drugs: Decrease serum levels of ciprofloxacin.
Caffeine: Enhanced efficacy of caffeine.
Oral anti-coagulants: Enhanced efficacy of anti-coagulants.
Cyclosporine: Nephrotoxicity increased by ciprofloxacin.
Theophylline: Increased plasma levels of theophylline resulting in toxicity.
NSAIDs: CNS excitation may occur.
Rifampicin: Decreases serum concenteration of ciprofloxacin.
Chloramphenicol: Antagonises effects of ciprofloxacin.Typical Dosage for CiprofloxacinAdults:
Dose is determined on the basis of severity of the infection, type of infecting organism, age, weight and renal function of the patient.
UTI: 0.5 - 1 g / day in 2 divided doses.
Respiratory tract infection, Bone and joint infections, Infectious diarrhoea, ENT infections, .Skin and soft tissue infections, Enteric fever: 1 - 1.5 g / day in 2 divided doses
Typhoid fever, Intra-abdominal infections, Gynaecological infection: 1 g / day in 2 divided doses
Uncomplicated gonorrhea: 250 mg / day
Schedule of CiprofloxacinHStorage Requirements for CiprofloxacinStore at 15 - 30 degree C in a tightly closed container.Effects of Missed Dosage of CiprofloxacinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Effects of Overdose of CiprofloxacinGive supportive measures and symptomatic treatment. Induce emesis or gastric lavage has to be done. Dialysis can be done if necessary.Fluocinolone acetonide
About Fluocinolone acetonideA synthetic hydrocortisone derivative, Vasoprotective ,reduce skin inflammation.Mechanism of Action of Fluocinolone acetonideFluocinolone is a topical high potency glucocorticoid.
The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits Phospholipase A2 and thus decreases the production of Prostaglandins, leukotrienes (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-?, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Fluocinolone also has immunosuppressant and antimitotic actions.
Pharmacokinets of Fluocinolone acetonideAbsorption: Fluocinolone is absorbed( <1 %) through intact skin after topical administration and the amount absorbed is depending on the type of inflammation, vehicle used, area of skin and the epidermal barrier.Onset of Action for Fluocinolone acetonideN/ADuration of Action for Fluocinolone acetonideN/AHalf Life of Fluocinolone acetonideN/ASide Effects of Fluocinolone acetonide1.Thinning of epidermis
2.Burning
3. Itching
4.Irritation
5.Atrophy (Dermal changes)
6.Telangiectasia
7.Striae
8. Hypopigmentation
9.Contact dermatitis
10.Perioral dermatitis
11.Stinging
12.Cataract,Glaucoma, Corneal ulcers caused by application around eyelids and surrounding skin
13. Hypertrichosis
14. Dryness
15. Acne
Contra-indications of Fluocinolone acetonide1. Hypersensitivity to Fluocinolone and other corticosteroids
2.Acne vulgaris
3.Acne Rosacea
4.Nappy rash
5. Tuberculosis infection of the skin
6.Viral, fungal or bacterial primary infections
7.Ulcers
Special Precautions while taking Fluocinolone acetonide1.Avoid application on large surface area
2. Prolonged use
3.Psoriasis
4.Avoid contact with eyes
5. Avoid occlusive dressing
6.Not used more than 5 days on the face or in the children
7. If irritation or hypersensitivity occurs avoid the use of medicaments.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Fluocinolone acetonide1.Psoriasis
2.Eczema
3.Otitis externa
4.Lichen simplex and planus
5.Anal and vulval pruritis
6.Contact dermatitis
7.Seborrheic dermatitis
8. Dermatoses (secondary infected)
Interactions for Fluocinolone acetonideN/ATypical Dosage for Fluocinolone acetonideTopical: Fluocinolone 0.0025 %, 0.01% cream, ointment, gel or lotion is used. Clean and dry the affected area and apply the medicament thinly and evenly on the affected area for 2 - 3 times daily for 2 weeks.Schedule of Fluocinolone acetonideN/AStorage Requirements for Fluocinolone acetonideStore at room temperature. Protect from heat and moisture. Keep out of the reach of childrenEffects of Missed Dosage of Fluocinolone acetonideApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Fluocinolone acetonideGive supportive measures and symptomatic treatment.Home Delivery for Clotrimazole + Ciprofloxacin + Fluocinolone acetonide in Your City
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Please be aware that you should take clotrimazole + ciprofloxacin + fluocinolone acetonide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for clotrimazole + ciprofloxacin + fluocinolone acetonide before they complete the sale. You can get this information while placing the order for clotrimazole + ciprofloxacin + fluocinolone acetonide with the pharmacy.
Clotrimazole + Ciprofloxacin + Fluocinolone acetonide is a generic medicine name and there are several brands available for it. Some of the brands for clotrimazole + ciprofloxacin + fluocinolone acetonide might be better known than clotrimazole + ciprofloxacin + fluocinolone acetonide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have clotrimazole + ciprofloxacin + fluocinolone acetonide in stock, you can ask for one of the branded alternatives for clotrimazole + ciprofloxacin + fluocinolone acetonide.
