Clobetasol propionate Pharmacology

Clobetasol propionate

About Clobetasol propionate
Topical adenocorticoid, Anti inflammatory.
Mechanism of Action of Clobetasol propionate
Clobetasol is a topical corticosteroid. It induces peptide Lipocortins which inhibit the enzyme Phospholipase A2. Phospholipase A2 is essential for the conversion of membrane phospholipids to Arachidonic acid. From this Arachidonic acid inflammatory mediators like prostaglandins, kinins, histamine, liposomal enzymes and the complement system are produced. By inhibiting Phospholipase A2 inflammatory mediators are not released. It also inhibits the migration of macrophages and leukocytes to the inflamed area by its vasoconstrictive properties. Corticosteroids also inhibit capillary production, collagen deposition and keloid (scar) formation. Thus inhibiting inflammatory mediators and other actions Clobetasol are used for anti-inflammatory conditions.
Pharmacokinets of Clobetasol propionate
Absorption: Clobetasol is absorbed through intact skin after topical administration and the amount absorbed is depending on the type of inflammation, vehicle used, amount of drug applied and the epidermal barrier (nature of skin)
Onset of Action for Clobetasol propionate
Duration of Action for Clobetasol propionate
Half Life of Clobetasol propionate
Side Effects of Clobetasol propionate
1.Thinning of epidermis
3. Itching
5.Atrophy (Dermal changes)
9.Contact dermatitis
10.Perioral dermatitis

Contra-indications of Clobetasol propionate
1.Hypersensitivity to Clobetasol and other corticosteroids
2.Acne vulgaris
3.Acne Rosacea
4.Nappy rash
5.Tuberculosis infection of the skin
6.Viral,fungal or bacterial primary infections
Special Precautions while taking Clobetasol propionate
1.Avoid application on large surface area
2.Prolonged use
4.Avoid contact with eyes,mouth and mucous membrane
5.Avoid occlusive dressing or plastic damage
6.Not used more than 5 days on the face or in the children
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Below12 years: Contraindicated
Indications for Clobetasol propionate
1.Skin disorders
4.Alopecia areata
5.Inflammation of corticosteroid dermatoses (secondary infected)
6.Chronic discoid lupus Erythematosus
Interactions for Clobetasol propionate
Typical Dosage for Clobetasol propionate
Topical: Clobetasol 0.05 % cream and gel are available. Medicament is applied thinly and evenly on the affected area. 2 times a day, maximum 2 weeks. Maximum dose: 50 g of the cream/ week.
Schedule of Clobetasol propionate
Storage Requirements for Clobetasol propionate
Store at room temperature. Protect from heat, moisture and light. Keep out of the reach of children
Effects of Missed Dosage of Clobetasol propionate
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Clobetasol propionate
Give supportive measures and symptomatic treatment.

Home Delivery for Clobetasol propionate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including clobetasol propionate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for clobetasol propionate and other medicines and health products. Home delivery services for clobetasol propionate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take clobetasol propionate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for clobetasol propionate before they complete the sale. You can get this information while placing the order for clobetasol propionate with the pharmacy.

Clobetasol propionate is a generic medicine name and there are several brands available for it. Some of the brands for clobetasol propionate might be better known than clobetasol propionate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have clobetasol propionate in stock, you can ask for one of the branded alternatives for clobetasol propionate.