Fluticasone Pharmacology


About Fluticasone
Synthetic topical glucocorticoid, Anti inflammatory and antipruritic in corticosteroid-responsive dermatoses; atopic dermatitis.
Mechanism of Action of Fluticasone
It reduces prostaglandin synthesis by inhibiting cyclo oxygenase enzymes both COX1 and COX2.In higher doses it reduces the thromboxane A2 synthesis by COX1 inhibition. So platelet aggregation is inhibited by this drug. After topical application in the case of ophthalmic preparation it prevents miosis by reducing ocular prostaglandins synthesis. It is a phenylalkalonic acid derivative Non Steroidal Anti Inflammatory Drug.
Pharmacokinets of Fluticasone
Absorption- Well absorbed orally.
Distribution-99% bound to the plasma proteins.
Metabolism- In liver it is metabolized by hydroxylation and conjugation.
Excretion-It is excreted through urine.
Onset of Action for Fluticasone
Duration of Action for Fluticasone
Half Life of Fluticasone
6-10 hrs
Side Effects of Fluticasone
1. Anxiety
2. Insomnia
3. Tremors
4. Depression
5. Heart failure
6. Visual changes
7. Renal failure
8. Thrombocytopenia
9. Aplastic anemia
10. Photosensitivity
11. Urticaria
12. Angioedema

Contra-indications of Fluticasone
1. Hypersensitivity to this drug
2. Peptic ulcer
3. Gastro intestinal bleeding
4. Bronchospasm
5. Hypersensitivity
6. Herpes simplex keratitis

Special Precautions while taking Fluticasone
1. Renal failure
2. Hyper tension
3. Hypersensitive to other Non Steroidal Anti Inflammatory Drugs

Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution.
NEONATES: contraindicated
Indications for Fluticasone
1. Rheumatoid arthritis
2. Osteo arthritis
3. Ankylosing spondylitis
4. Pain in patients with dysmenorrhea.
5. Post operative inflammation of the eye.
6. Migraine
7. Acute gout
Interactions for Fluticasone
None reported.
Typical Dosage for Fluticasone
Adults- 200-300mg/day in 2-4 divided doses.
Topicaly-0.03% ophthalmic solution. Add 1 drop in every ? hr to the eyes beginning 2-3 hrs before surgery.

Schedule of Fluticasone
Storage Requirements for Fluticasone
Store in a sealed container at room a temperature and avoid moisture.
In the case of ophthalmic preparation stored between 15 and 30 degree Celsius.
Effects of Missed Dosage of Fluticasone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Fluticasone
Supportive and symptomatic treatment should be given. Empty the stomach by emesis or gastric lavage.

Home Delivery for Fluticasone in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including fluticasone.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for fluticasone and other medicines and health products. Home delivery services for fluticasone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take fluticasone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for fluticasone before they complete the sale. You can get this information while placing the order for fluticasone with the pharmacy.

Fluticasone is a generic medicine name and there are several brands available for it. Some of the brands for fluticasone might be better known than fluticasone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have fluticasone in stock, you can ask for one of the branded alternatives for fluticasone.