Alclometasone dipropionate Pharmacology

Alclometasone dipropionate

About Alclometasone dipropionate
Adrenocorticoid (topical), anti-inflammatory, antipruritic, and vasoconstrictive.
Mechanism of Action of Alclometasone dipropionate
The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows its migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemotaxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Alclometasone dipropionate
Absorption: After topical application small amount is absorbed. Distribution: It is distributed mainly in the skin. Small amount is distributed into muscle, skin, liver, intestine and kidney
Onset of Action for Alclometasone dipropionate
Duration of Action for Alclometasone dipropionate
Half Life of Alclometasone dipropionate
Side Effects of Alclometasone dipropionate
Contra-indications of Alclometasone dipropionate
1.Hypersensitivity to Alclomethasone
2.Inflammation of corticosteroid responsive dermatoses
Special Precautions while taking Alclometasone dipropionate
1.Skin infection
Pregnancy Related Information
Use with caution
Old Age Related Information
Breast Feeding Related Information
Use with caution
Children Related Information
Indications for Alclometasone dipropionate
Interactions for Alclometasone dipropionate
Typical Dosage for Alclometasone dipropionate
Apply the medicament as thin film in the affected area 2 - 3 times daily. Gently massage until medicaments disappears.
Schedule of Alclometasone dipropionate
Storage Requirements for Alclometasone dipropionate
Store the medicine at room temperature, away from heat and direct light. Keep the medicine out of the reach of children.
Effects of Missed Dosage of Alclometasone dipropionate
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Alclometasone dipropionate

Home Delivery for Alclometasone dipropionate in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for alclometasone dipropionate and other medicines and health products. Home delivery services for alclometasone dipropionate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take alclometasone dipropionate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for alclometasone dipropionate before they complete the sale. You can get this information while placing the order for alclometasone dipropionate with the pharmacy.

Alclometasone dipropionate is a generic medicine name and there are several brands available for it. Some of the brands for alclometasone dipropionate might be better known than alclometasone dipropionate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have alclometasone dipropionate in stock, you can ask for one of the branded alternatives for alclometasone dipropionate.