Clobetasone butyrate Pharmacology

Clobetasone butyrate

About Clobetasone butyrate
A new corticosteroid, Anti inflammatory.
Mechanism of Action of Clobetasone butyrate
Clobetasone is a topical corticosteroid. It induces peptide Lipocortins which inhibit the enzyme Phospholipase A2. Phospholipase A2 is essential for the conversion of membrane phospholipids to Arachidonic acid. From this Arachidonic acid inflammatory mediators like prostaglandins, kinins, histamine, liposomal enzymes and the complement system are produced. By inhibiting Phospholipase A2 inflammatory mediators are not released. It also inhibits the migration of macrophages and leukocytes to the inflamed area by its vasoconstrictive properties. Corticosteroids also inhibit capillary production, collagen deposition and keloid (scar) formation on the inflamed area. Thus inhibiting inflammatory mediators and other actions Clobetasone are used for anti-inflammatory conditions.

Pharmacokinets of Clobetasone butyrate
Absorption: Clobetasone is absorbed through intact skin after topical administration and the amount absorbed is depending on the type of inflammation, vehicle used and the epidermal barrier
Onset of Action for Clobetasone butyrate
Duration of Action for Clobetasone butyrate
Half Life of Clobetasone butyrate
Side Effects of Clobetasone butyrate
1.Thinning of epidermis
5.Atrophy (Dermal changes)
9.Contact dermatitis
10.Perioral dermatitis
11.Cataract, Glaucoma, Corneal ulcers Caused by application around eyelids and surrounding skin
Contra-indications of Clobetasone butyrate
1.Hypersensitivity to Clobetasone and other corticosteroids
2.Acne vulgaris
3.Acne Rosacea
4.Nappy rash
5.Tuberculosis infection of the skin
6.Viral, fungal or bacterial primary infections
Special Precautions while taking Clobetasone butyrate
1.Avoid application on large surface area
2.Prolonged use
4.Avoid contact with eyes
5.Avoid occlusive dressing
6.Not used more than 5 days on the face or in the children, 6. For external use only
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Clobetasone butyrate
Skin disorders.
1.Otitis externa
5.Intertrigo (Inflammation in the skin folds)
6.Seborrheic dermatitis
7.Allergy or irritant dermatitis
8.Dermatoses (secondary infected)
9.Reaction to insect bite and stings
Interactions for Clobetasone butyrate
Typical Dosage for Clobetasone butyrate
Topical: Clobetasone 0.05 % cream is used. Apply the medicament thinly and evenly on the affected area 3- 4 times daily. Maximum drug100 g / week
Schedule of Clobetasone butyrate
Storage Requirements for Clobetasone butyrate
Store at room temperature. Protect from heat and light. Keep out of the reach of children
Effects of Missed Dosage of Clobetasone butyrate
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Clobetasone butyrate
Give supportive measures and symptomatic treatment.

Home Delivery for Clobetasone butyrate in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for clobetasone butyrate and other medicines and health products. Home delivery services for clobetasone butyrate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take clobetasone butyrate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for clobetasone butyrate before they complete the sale. You can get this information while placing the order for clobetasone butyrate with the pharmacy.

Clobetasone butyrate is a generic medicine name and there are several brands available for it. Some of the brands for clobetasone butyrate might be better known than clobetasone butyrate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have clobetasone butyrate in stock, you can ask for one of the branded alternatives for clobetasone butyrate.