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- Pharmacology For Clobetasone butyrate
Clobetasone butyrate Pharmacology
Clobetasone butyrateAbout Clobetasone butyrateA new corticosteroid, Anti inflammatory.Mechanism of Action of Clobetasone butyrateClobetasone is a topical corticosteroid. It induces peptide Lipocortins which inhibit the enzyme Phospholipase A2. Phospholipase A2 is essential for the conversion of membrane phospholipids to Arachidonic acid. From this Arachidonic acid inflammatory mediators like prostaglandins, kinins, histamine, liposomal enzymes and the complement system are produced. By inhibiting Phospholipase A2 inflammatory mediators are not released. It also inhibits the migration of macrophages and leukocytes to the inflamed area by its vasoconstrictive properties. Corticosteroids also inhibit capillary production, collagen deposition and keloid (scar) formation on the inflamed area. Thus inhibiting inflammatory mediators and other actions Clobetasone are used for anti-inflammatory conditions.
Pharmacokinets of Clobetasone butyrateAbsorption: Clobetasone is absorbed through intact skin after topical administration and the amount absorbed is depending on the type of inflammation, vehicle used and the epidermal barrierOnset of Action for Clobetasone butyrateN/ADuration of Action for Clobetasone butyrateN/AHalf Life of Clobetasone butyrateN/ASide Effects of Clobetasone butyrate1.Thinning of epidermis
5.Atrophy (Dermal changes)
11.Cataract, Glaucoma, Corneal ulcers Caused by application around eyelids and surrounding skinContra-indications of Clobetasone butyrate1.Hypersensitivity to Clobetasone and other corticosteroids
5.Tuberculosis infection of the skin
6.Viral, fungal or bacterial primary infections
7.UlcersSpecial Precautions while taking Clobetasone butyrate1.Avoid application on large surface area
4.Avoid contact with eyes
5.Avoid occlusive dressing
6.Not used more than 5 days on the face or in the children, 6. For external use onlyPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Clobetasone butyrateSkin disorders.
5.Intertrigo (Inflammation in the skin folds)
7.Allergy or irritant dermatitis
8.Dermatoses (secondary infected)
9.Reaction to insect bite and stings
Interactions for Clobetasone butyrateN/ATypical Dosage for Clobetasone butyrateTopical: Clobetasone 0.05 % cream is used. Apply the medicament thinly and evenly on the affected area 3- 4 times daily. Maximum drug100 g / weekSchedule of Clobetasone butyrateN/AStorage Requirements for Clobetasone butyrateStore at room temperature. Protect from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of Clobetasone butyrateApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Clobetasone butyrateGive supportive measures and symptomatic treatment.
Home Delivery for Clobetasone butyrate in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including clobetasone butyrate.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for clobetasone butyrate and other medicines and health products. Home delivery services for clobetasone butyrate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take clobetasone butyrate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for clobetasone butyrate before they complete the sale. You can get this information while placing the order for clobetasone butyrate with the pharmacy.
Clobetasone butyrate is a generic medicine name and there are several brands available for it. Some of the brands for clobetasone butyrate might be better known than clobetasone butyrate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have clobetasone butyrate in stock, you can ask for one of the branded alternatives for clobetasone butyrate.