Hydrocortisone Topical Pharmacology

Hydrocortisone Topical

About Hydrocortisone Topical
Topical synthetic glucocorticoid, anti-inflammatory and anti-pruritic.
Mechanism of Action of Hydrocortisone Topical
The drug exerts it`s pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts both glucocorticoid and mineralocorticoid actions.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Hydrocortisone Topical
Absorption: Absorption ranges from 1% to 36% after topical application.
Distribution: Distributed throughout the local skin layers. Any drug absorbed in to circulation is rapidly removed from blood and distributed in to muscle, liver, kidney, skin, and intestine.
Metabolism: Metabolized primarily in skin and a small amount absorbed is metabolized in liver.
Excretion: Metabolites are excreted mainly through urine and a small amount is excreted through faeces.
Onset of Action for Hydrocortisone Topical
N/A
Duration of Action for Hydrocortisone Topical
N/A
Half Life of Hydrocortisone Topical
N/A
Side Effects of Hydrocortisone Topical
1. Burning
2. Irritation
3. Pruritus
4. Dryness
5. Erythema
6. Folliculitis
7. Hypertrichosis
8. Acneiform eruptions
9. Allergic contact dermatitis
10. Secondary infections
11. Atrophy
12. Striae
Contra-indications of Hydrocortisone Topical
1. Hypersensitivity to the drug
2. Local or systemic infections
3. Fungal or herpetic keratitis
4. Cataract
5. Tubercular or syphilitic lesions
Special Precautions while taking Hydrocortisone Topical
1. Occlusive dressings
2. Use of potent preparations should be short term or intermittent
3. Milder drugs should be used in acute lesions and stronger ones are for chronic lesions
4. Avoid sudden discontinuation of the drug.
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES : Contraindicated
Indications for Hydrocortisone Topical
1. Treatment of skin disorders: Dermatitis, Eczema,Psoriasis
2. Inflammations of corticosteroid-responsive dermatoses
3. Seborrheic dermatitis of scalp
Interactions for Hydrocortisone Topical
Carbamazepine, Primidone: Decreases efficacy.
Oral contraceptives: Increase concentration of hydrocortisone.
Oestrogens: Decreases clearance of hydrocortisone.
Ketoconazole: Decreases clearance of hydrocortisone.
Rifampicin: Decreases efficacy.
Hydrocortisone effects the actions of the following:
Anticholinesterases: Efficacy antagonised in myasthenia gravis.
Oral anticoagulants: Altered response.
Cyclosporine: Increases efficacy, enhanced toxicity may occur.
Digitalis glycosides: May enhance toxicity.
Isoniazid: Decreases serum levels.
Salicylates: Decreases serum levels.
Diuretics (K sparing): May cause hypokalaemia.
Non-depolarising muscle relaxants: Altered response of either agent may occur.
Somatrem: Growth promoting effect inhibited.
Theophyllines: Altered response of either agent.
Lab. Tests: Increases serum cholesterol levels. Increases urine glucose levels. Decreases Thyroid I131 uptake; Decreases T3 serum levels. Decreases serum potassium.
Typical Dosage for Hydrocortisone Topical
Cream:
Apply 0.1% to 2.5% 1 to 4 times daily.
Ointment:
0.5% to 2.5% Apply 1 to 4 times as required
Lotion:
0.25% to 2.5% Apply 1 to 4 times as required
Gel:
0.5% to 1% Apply 1 to 4 times as required
Aerosol:
Seborrheic dermatitis of scalp:
0.5% to 1%Apply for only 3seconds. Directly spray in to the affected area from 15 cm apart. No need for massage or rub. Apply 1 to 4 times daily until acute phase is controlled. Then reduce the dosage to 0nce to thrice weekly.


Schedule of Hydrocortisone Topical
H
Storage Requirements for Hydrocortisone Topical
Store at room temperature at a range of 15 to 30 degree C. Protect from light and moisture. Keep out of reach of children.
Effects of Missed Dosage of Hydrocortisone Topical
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Hydrocortisone Topical
Provide symptomatic treatment and supportive measures.

Home Delivery for Hydrocortisone Topical in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for hydrocortisone topical and other medicines and health products. Home delivery services for hydrocortisone topical may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take hydrocortisone topical only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for hydrocortisone topical before they complete the sale. You can get this information while placing the order for hydrocortisone topical with the pharmacy.

Hydrocortisone Topical is a generic medicine name and there are several brands available for it. Some of the brands for hydrocortisone topical might be better known than hydrocortisone topical itself. If the pharmacy that's willing to deliver medicines to your home doesn't have hydrocortisone topical in stock, you can ask for one of the branded alternatives for hydrocortisone topical.