Betamethasone valerate + Salicylic acid Pharmacology

Betamethasone valerate + Salicylic acid

About Betamethasone valerate + Salicylic acid
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Mechanism of Action of Betamethasone valerate + Salicylic acid
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Pharmacokinets of Betamethasone valerate + Salicylic acid
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Onset of Action for Betamethasone valerate + Salicylic acid
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Duration of Action for Betamethasone valerate + Salicylic acid
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Half Life of Betamethasone valerate + Salicylic acid
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Side Effects of Betamethasone valerate + Salicylic acid
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Contra-indications of Betamethasone valerate + Salicylic acid
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Special Precautions while taking Betamethasone valerate + Salicylic acid
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Pregnancy Related Information
Use with caution; since Betamethasone valerate is used with caution in pregnancy
Old Age Related Information
N/A
Breast Feeding Related Information
Use with caution; since Betamethasone valerate is used with caution in breast feeding mother
Children Related Information
N/A
Indications for Betamethasone valerate + Salicylic acid
It is a combination of corticosteroid Betamethasone valerate and keratolytic Salicylic acid. Salicylic acid breaks down the keratin in the hardened and thickened skin and helps to shed skin cells from the area to which it is applied. It also improves the penetration of the Betamethasone into the skin and making it more effective.
1.Psoriasis
2.Eczema
3.Dry, scaly, inflamed skin conditions
Interactions for Betamethasone valerate + Salicylic acid
N/A
Typical Dosage for Betamethasone valerate + Salicylic acid
Apply the medicament to the affected part 1 - 3 times daily.
Schedule of Betamethasone valerate + Salicylic acid
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Storage Requirements for Betamethasone valerate + Salicylic acid
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Effects of Missed Dosage of Betamethasone valerate + Salicylic acid
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Effects of Overdose of Betamethasone valerate + Salicylic acid
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Betamethasone valerate

About Betamethasone valerate
It is a topical steroid
Mechanism of Action of Betamethasone valerate
The drug exerts it`s pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemotaxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Betamethasone valerate
Absorption: It is absorbed in to the systemic circulation and the amount is depending on the potency, amount applied and the nature of the skin at the site of application. Absorption increases at the site of skin damage, inflammation or occlusion.

Onset of Action for Betamethasone valerate
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Duration of Action for Betamethasone valerate
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Half Life of Betamethasone valerate
N/A
Side Effects of Betamethasone valerate
1.Thinning of the skin
2.Loss of elasticity
3.Increased hair growth
4.Acne at the site of application
5.Mild depigmentation
6.Rosacea
Contra-indications of Betamethasone valerate
1.Untreated bacterial, virus or fungal infections
2.Acne vulgaris,
3.Peri-oral dermatitis,
4.Scabies,
5.Leg ulcers,
6.Tuberculosis of the skin,
7.Varicose ulcers,
8.Skin lesions caused by infections with ring worm,. fungi (e.g. Candida, Tinea) or bacteria (e.g. impetigo)
9.Hypersensitivity to Betamethasone and other corticosteroids.
10.Discoid lupus Erythematosus
Special Precautions while taking Betamethasone valerate
1.Avoid contact with eyes
2.For external use only
3.Prolonged use
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Betamethasone valerate
1.Psoriasis,
2.Eczema,
3.Otitis externa,
4.Lichen simplex and planus,
5.Anal and vulval Pruritis,
6.Seborrheic dermatitis,
7.Contact dermatitis,
8.Steroidal responsive dermatoses of the scalp
Interactions for Betamethasone valerate
N/A
Typical Dosage for Betamethasone valerate
Topical:
Betamethasone Valerate: Apply to the affected area as thin film 1 - 4 times daily depending upon the severity, skin and rate of absorption.
Dermatoses of the scalp: (Betamethasone Valerate 0.12%): Small amount of foam is applied in to the scalp with gentle massage 2 times a day for up to 2 weeks.
Schedule of Betamethasone valerate
N/A
Storage Requirements for Betamethasone valerate
Store at room temperature in a well closed; light resistant container. Protect from excess heat and moisture. Keep out of reach of children.
Effects of Missed Dosage of Betamethasone valerate
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Betamethasone valerate
Provide symptomatic treatment and supportive measures.

Salicylic Acid

About Salicylic Acid
A beta hydroxy acid, Keratolytic, Topical Skin Product(Anti Acne).
Mechanism of Action of Salicylic Acid
It is a keratolytic agent. It encourages exfoliation of the skin and opening up of the plugged follicles, which helps re-establish the normal skin- cell replacement cycle. For milder acne, salicylic acid helps unclog pores to resolve and prevent lesions.
Pharmacokinets of Salicylic Acid
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Onset of Action for Salicylic Acid
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Duration of Action for Salicylic Acid
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Half Life of Salicylic Acid
N/A
Side Effects of Salicylic Acid
1.Allergic reaction
2.Hives
3.Difficulty breathing
4.Swelling of your face, lips, tongue, or throat.
Contra-indications of Salicylic Acid
1.Hypersensitivity to Salicylic acid
Special Precautions while taking Salicylic Acid
1.Avoid contact with eyes, mouth, or nose.
2.Like many other topical acne treatments, salicylic acid must be used continuously, even after acne lesions have.
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Salicylic Acid
1.Treats skin irritation and inflammation caused by burns, insect bites, fungal infections, and eczema.
Interactions for Salicylic Acid
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Typical Dosage for Salicylic Acid
Use this medication twice daily
Schedule of Salicylic Acid
N/A
Storage Requirements for Salicylic Acid
Store in a cool dry place. Protect from heat and light. Keep out of the reach of children
Effects of Missed Dosage of Salicylic Acid
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Salicylic Acid
Give supportive measures and symptomatic treatment.

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Betamethasone valerate + Salicylic acid is a generic medicine name and there are several brands available for it. Some of the brands for betamethasone valerate + salicylic acid might be better known than betamethasone valerate + salicylic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have betamethasone valerate + salicylic acid in stock, you can ask for one of the branded alternatives for betamethasone valerate + salicylic acid.