- Medicine India
- Generic Medicines
- T
- Pharmacology For Tretinoin + Clindamycin Topical
Tretinoin + Clindamycin Topical Pharmacology
Tretinoin + Clindamycin Topical
About Tretinoin + Clindamycin TopicalN/AMechanism of Action of Tretinoin + Clindamycin TopicalN/APharmacokinets of Tretinoin + Clindamycin TopicalN/AOnset of Action for Tretinoin + Clindamycin TopicalN/ADuration of Action for Tretinoin + Clindamycin TopicalN/AHalf Life of Tretinoin + Clindamycin TopicalN/ASide Effects of Tretinoin + Clindamycin TopicalN/AContra-indications of Tretinoin + Clindamycin TopicalN/ASpecial Precautions while taking Tretinoin + Clindamycin TopicalN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Tretinoin + Clindamycin TopicalN/AInteractions for Tretinoin + Clindamycin TopicalN/ATypical Dosage for Tretinoin + Clindamycin TopicalN/ASchedule of Tretinoin + Clindamycin TopicalN/AStorage Requirements for Tretinoin + Clindamycin TopicalN/AEffects of Missed Dosage of Tretinoin + Clindamycin TopicalN/AEffects of Overdose of Tretinoin + Clindamycin TopicalN/ATretinoin
About TretinoinRetinoid, vitamin A metabolite, Anti-acne,in hyperpigmentation.Mechanism of Action of TretinoinTretinoin is All Trans retinoic acid (acid form of vitamin A). Tretinoin is a potent comedolytic. It stimulates mitosis and epidermal cell turnover and also promotes lysis of keratocytes. It inhibits the binding of horny cells to each other and prevents the formation of comedones. It acts as a follicular epithelium irritant. Through these actions, the comedo contents are extruded and the formation of the microcomedo, the precursor lesion of acne vulgaris, is reducedPharmacokinets of TretinoinAbsorption: Absorption after topical application is minimal.Onset of Action for TretinoinN/ADuration of Action for TretinoinN/AHalf Life of TretinoinN/ASide Effects of Tretinoin1. Feeling of warmth
2. Stinging
3. Erythema
4. Peeling
5. Blisters
6. Crusting
7. Pigmentation (hypo/hyper)
8. Contact dermatitis
9. Itching
10. Rredness
11. Edema
Contra-indications of Tretinoin1. Hypersensitivity to Tretinoin and other Retinoid
2. Abraded skin
3. Sunburn
Special Precautions while taking Tretinoin1. Eczema
2. Avoid contact with eyes, nose, mucous membrane, open wounds
3. Avoid use of medicated cosmetics and topical preparations containing high level of alcohols, spices or lime
4. Minimize exposure to sunlight and ultraviolet light
5. Avoid concomitant use of keratolytic agents
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Use with caution
Indications for Tretinoin1. Acne
2. Wrinkles
3. Photo ageing of skin
4. Dry scaly surface
Interactions for TretinoinSulfer, Resorcinol, Benzoyl peroxide or Salicylic acid : Concomitant use of topical keratolytic medications may result in significant skin irritation. Use medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect and products with high concentration of alcohol, astringents, spices or lime cautiously because of possible interaction with tretinion.Typical Dosage for TretinoinTopical:
Acne: 0.01-0.1% cream/gel/solution on the affected area 1-2 times daily.
Wrinkling: 0.05% cream is applied once daily at night.
Schedule of TretinoinHStorage Requirements for TretinoinStore at 15 - 25 degree C in a tightly closed container.Effects of Missed Dosage of TretinoinApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of TretinoinGive supportive measures and symptomatic treatment.Clindamycin Topical
About Clindamycin TopicalMacrolide, Lincosamide Antibiotic (Topical).Mechanism of Action of Clindamycin TopicalIt binds to the 50S sub unit of bacterial ribosome and inhibits translocation.ie:they interfere with the transfer of the newly formed peptide chain from the A site to the P site and fails to expose the A site .So that A site is unable to bind with the next aminoacyl t RNA complex. This leads to premature termination of amino acid chain and there by inhibits protein synthesis.Pharmacokinets of Clindamycin TopicalAbsorption: It is minimally absorbed after topical application.Onset of Action for Clindamycin TopicalN/ADuration of Action for Clindamycin TopicalN/AHalf Life of Clindamycin TopicalN/ASide Effects of Clindamycin Topical1.Burning
2.Stinging
3.Dryness
4.Redness
5.Oiliness
6.Itching
7.Mild irritation
Contra-indications of Clindamycin Topical1.Hypersensitive to Clindamycin
Special Precautions while taking Clindamycin Topical1. Avoid contact with eyes, nose, mouth, and lips and if medication gets in any of these areas, wash with water
2.Avoid use of medicament to broken or irritated skin
3. Avoid using other topical products on the same area at the same
4.History of enteritis, ulcerative colitis, or antibiotic-associated colitis
Pregnancy Related InformationUse with caution.Old Age Related InformationMay be usedBreast Feeding Related InformationUse with caution.Children Related InformationUse with caution.Indications for Clindamycin Topical1.Acne vulgarisInteractions for Clindamycin TopicalN/ATypical Dosage for Clindamycin TopicalApply once daily to washed and dried areas for maximum of 15 minutes initially and increase the exposure graduallySchedule of Clindamycin TopicalN/AStorage Requirements for Clindamycin TopicalThe drug should be store at room temperature.Keep out of reach of children.Effects of Missed Dosage of Clindamycin TopicalApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Clindamycin TopicalGive supportive measures and symptomatic treatment.Home Delivery for Tretinoin + Clindamycin Topical in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including tretinoin + clindamycin topical.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for tretinoin + clindamycin topical and other medicines and health products. Home delivery services for tretinoin + clindamycin topical may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take tretinoin + clindamycin topical only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for tretinoin + clindamycin topical before they complete the sale. You can get this information while placing the order for tretinoin + clindamycin topical with the pharmacy.
Tretinoin + Clindamycin Topical is a generic medicine name and there are several brands available for it. Some of the brands for tretinoin + clindamycin topical might be better known than tretinoin + clindamycin topical itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tretinoin + clindamycin topical in stock, you can ask for one of the branded alternatives for tretinoin + clindamycin topical.
