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- Pharmacology For Tretinoin + Erythromycin
Tretinoin + Erythromycin Pharmacology
Tretinoin + Erythromycin
About Tretinoin + ErythromycinN/AMechanism of Action of Tretinoin + ErythromycinN/APharmacokinets of Tretinoin + ErythromycinN/AOnset of Action for Tretinoin + ErythromycinN/ADuration of Action for Tretinoin + ErythromycinN/AHalf Life of Tretinoin + ErythromycinN/ASide Effects of Tretinoin + ErythromycinN/AContra-indications of Tretinoin + ErythromycinN/ASpecial Precautions while taking Tretinoin + ErythromycinN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Tretinoin + ErythromycinN/AInteractions for Tretinoin + ErythromycinN/ATypical Dosage for Tretinoin + ErythromycinN/ASchedule of Tretinoin + ErythromycinN/AStorage Requirements for Tretinoin + ErythromycinN/AEffects of Missed Dosage of Tretinoin + ErythromycinN/AEffects of Overdose of Tretinoin + ErythromycinN/ATretinoin
About TretinoinRetinoid, vitamin A metabolite, Anti-acne,in hyperpigmentation.Mechanism of Action of TretinoinTretinoin is All Trans retinoic acid (acid form of vitamin A). Tretinoin is a potent comedolytic. It stimulates mitosis and epidermal cell turnover and also promotes lysis of keratocytes. It inhibits the binding of horny cells to each other and prevents the formation of comedones. It acts as a follicular epithelium irritant. Through these actions, the comedo contents are extruded and the formation of the microcomedo, the precursor lesion of acne vulgaris, is reducedPharmacokinets of TretinoinAbsorption: Absorption after topical application is minimal.Onset of Action for TretinoinN/ADuration of Action for TretinoinN/AHalf Life of TretinoinN/ASide Effects of Tretinoin1. Feeling of warmth
2. Stinging
3. Erythema
4. Peeling
5. Blisters
6. Crusting
7. Pigmentation (hypo/hyper)
8. Contact dermatitis
9. Itching
10. Rredness
11. Edema
Contra-indications of Tretinoin1. Hypersensitivity to Tretinoin and other Retinoid
2. Abraded skin
3. Sunburn
Special Precautions while taking Tretinoin1. Eczema
2. Avoid contact with eyes, nose, mucous membrane, open wounds
3. Avoid use of medicated cosmetics and topical preparations containing high level of alcohols, spices or lime
4. Minimize exposure to sunlight and ultraviolet light
5. Avoid concomitant use of keratolytic agents
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Use with caution
Indications for Tretinoin1. Acne
2. Wrinkles
3. Photo ageing of skin
4. Dry scaly surface
Interactions for TretinoinSulfer, Resorcinol, Benzoyl peroxide or Salicylic acid : Concomitant use of topical keratolytic medications may result in significant skin irritation. Use medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect and products with high concentration of alcohol, astringents, spices or lime cautiously because of possible interaction with tretinion.Typical Dosage for TretinoinTopical:
Acne: 0.01-0.1% cream/gel/solution on the affected area 1-2 times daily.
Wrinkling: 0.05% cream is applied once daily at night.
Schedule of TretinoinHStorage Requirements for TretinoinStore at 15 - 25 degree C in a tightly closed container.Effects of Missed Dosage of TretinoinApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of TretinoinGive supportive measures and symptomatic treatment.Erythromycin
About ErythromycinMacrolide Antibiotic.Mechanism of Action of ErythromycinErythromycin is a member of macrolide antibiotics. It binds to the 50S sub unit of bacterial ribosome and inhibits translocation.ie: they interfere with the transfer of the newly formed peptide chain from the A site to the P site and fails to expose the A site .So that A site is unable to bind with the next aminoacyl t RNA complex. This leads to premature termination of amino acid chain and there by inhibits protein synthesis.Pharmacokinets of ErythromycinAbsorption: The buffered form of erythromycin is completely absorbed.Distribution: It is widely distributed in the body in protein bound form.Metabolism: small portion undergo metabolism to inactive compound.Excretion: It is primarily excreted through bile and also through urine and breast milk.Onset of Action for Erythromycin2 - 4 hourDuration of Action for Erythromycin8 - 12 hourHalf Life of Erythromycin1 - 2 hourSide Effects of Erythromycin1.Nausea
2.Vomiting
3.Diarrhea
4.Epigastric pain
5.Fever
6.Rash
7.Urticaria
8.Super infection
9.Dryness
10.Pruritis
11.Cholestatic jaundice
12.Hearing disturbances (Ototoxicity)
Contra-indications of Erythromycin1.Hypersensitivity to erythromycin and other macrolide
2.Liver disease
Special Precautions while taking Erythromycin1.Renal impairment
2.Hepatic dysfunction
3.Arrhythmia
4.Heart failure
Pregnancy Related InformationUse with caution.Old Age Related InformationMay be used.Breast Feeding Related InformationUse with caution.Children Related InformationN/AIndications for Erythromycin1.Tonsilitis
2.Pharyngitis
3.Pneumonia
4.Diphtheria
5.Pertusis
6.Tetanus
7.SABE
8.Syphilis
9.Gonorrhea
10.Wound and burn infection
11.Rheumatic fever
12.Acne
13.Urogenital infection
14.Chancroid
15.Intestinal amoebiasis
16.Skin and soft tissue infections
17.Urethritis
Interactions for ErythromycinAnticoagulants: Efficacy enhanced leading to haemorrhages.
Bromocriptine: Efficacy protentiated leading to toxicity.
Carbamazepine: Dangerous toxic side effects requiring resuscitative measures and hospitalisation.
Digoxin: Serum levels of digoxin enhanced, leading to toxicity.
Disopyramide: Increased disopyramide plasma levels leading to arrhythmias.
Ergot Alkaloids: Acute ergotism manifested as peripheral ischaemia.
Methylprednisolone: Decreases methylprednisolone clearance.
Penicillins: Alters efficacy, may be synergistic or antagonist.
Theophylline: Increased serum theophylline levels resulting in toxicity. Decreased serum levels of erythromycin.
Triozolam: Increased CNS depression.Typical Dosage for ErythromycinAdult: 250 - 500 mg every 6 hours
Pneumonia: 250 - 500 mg four times daily for 2 - 3 weeks
Diphtheria: 500 mg four times daily for 1 - 2 weeks
Pertusis: 2 g /day in four divided dose for 2 weeks
Chancroid, Urogenital infections: 500 mg every 6 hours for 1 week
Urethritis: 500 mg orally four times a day for 7 days
Children: 30 - 60 mg/kg body weight/day in 4 divided dose
Pnumonia: 50 mg/kg body weight/day in four divided dose for 3 week
Conjunctivitis: 50 mg/ kg body weight/day in four divided dose for 2 week
Schedule of ErythromycinN/AStorage Requirements for ErythromycinStore in a cool dark place. Keep away from heat and moisture.Effects of Missed Dosage of ErythromycinTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of ErythromycinGive supportive measures and treatmentHome Delivery for Tretinoin + Erythromycin in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including tretinoin + erythromycin.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for tretinoin + erythromycin and other medicines and health products. Home delivery services for tretinoin + erythromycin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take tretinoin + erythromycin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for tretinoin + erythromycin before they complete the sale. You can get this information while placing the order for tretinoin + erythromycin with the pharmacy.
Tretinoin + Erythromycin is a generic medicine name and there are several brands available for it. Some of the brands for tretinoin + erythromycin might be better known than tretinoin + erythromycin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tretinoin + erythromycin in stock, you can ask for one of the branded alternatives for tretinoin + erythromycin.
