Adapalene Pharmacology

Adapalene

About Adapalene
Naphthoic acid derivative(a synthetic retinoid like compound), Anti-acne (Acne vulgaris).
Mechanism of Action of Adapalene
Adapalene is a chemically stable retinoid-like compound and is a derivative of naphthoic acid. Adapalene binds to specific retinoic acid nuclear receptors and it normalizes differentiation of follicular epithelial cells resulting in decreased comedones (black and white heads) formation. Adapalene inhibits the chemotactic (directional) and chemo kinetic (random) responses of human polymorphonuclear leucocytes and also inhibits the formation of inflammatory mediators by inhibiting metabolism of arachidonic acid. Adapalene also modulates cellular differentiation, keratinization, and inflammatory processes.
Pharmacokinets of Adapalene
Absorption: Absorption after topical administration is minimal
Onset of Action for Adapalene
N/A
Duration of Action for Adapalene
N/A
Half Life of Adapalene
N/A
Side Effects of Adapalene
1.Irritation
2.Scaling
3.Erythema
4.Dryness
5.Stinging
6.Burning
7.Pruritis
8.Redness
Contra-indications of Adapalene
Hypersensitivity to Adapalene
Special Precautions while taking Adapalene
1. Eczema
2. Sun burn
3.Avoid contact with eyes, mucous membrane ,lips, nose, wounds, abrasions, scaly skins
4.Avoid exposure to sunlight and ultraviolet light
5.Use a sunscreen and protective clothing if sun exposure is unavoidable
6.Avoid preparations containing sulphur, Resorcinol, or salicylic acid
7.Avoid occlusive dressing
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Below12 years: contraindicated
NEONATES: contraindicated
Indications for Adapalene
Acne vulgaris
Interactions for Adapalene
Topical products with a potential for irritation (medicated or abrasive soaps, and cleansers, soaps and cosmetics that have a strong drying effect, and products with high concentrations of alcohol, astringents, spices, or lime), particularly preparations containing sulphur, resorcinol, or salicylic acid in combination with adapalene: Exercise caution with concomitant use of adapalene.

Typical Dosage for Adapalene
Adapalene 0.1% gel is used. Clean and dry the affected area and apply the medicament once daily (at night) for 3 months for acne and 1-4 weeks for psoriasis
Schedule of Adapalene
H
Storage Requirements for Adapalene
Store at room temperature away from moisture and heat. Keep out of the reach of children
Effects of Missed Dosage of Adapalene
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Adapalene
Give supportive measures and symptomatic treatment.

Home Delivery for Adapalene in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including adapalene.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for adapalene and other medicines and health products. Home delivery services for adapalene may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take adapalene only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for adapalene before they complete the sale. You can get this information while placing the order for adapalene with the pharmacy.

Adapalene is a generic medicine name and there are several brands available for it. Some of the brands for adapalene might be better known than adapalene itself. If the pharmacy that's willing to deliver medicines to your home doesn't have adapalene in stock, you can ask for one of the branded alternatives for adapalene.