Meloxicam + Paracetamol Pharmacology

Meloxicam + Paracetamol

About Meloxicam + Paracetamol
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Mechanism of Action of Meloxicam + Paracetamol
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Pharmacokinets of Meloxicam + Paracetamol
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Onset of Action for Meloxicam + Paracetamol
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Duration of Action for Meloxicam + Paracetamol
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Half Life of Meloxicam + Paracetamol
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Side Effects of Meloxicam + Paracetamol
N/A
Contra-indications of Meloxicam + Paracetamol
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Special Precautions while taking Meloxicam + Paracetamol
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Meloxicam + Paracetamol
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Interactions for Meloxicam + Paracetamol
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Typical Dosage for Meloxicam + Paracetamol
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Schedule of Meloxicam + Paracetamol
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Storage Requirements for Meloxicam + Paracetamol
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Effects of Missed Dosage of Meloxicam + Paracetamol
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Effects of Overdose of Meloxicam + Paracetamol
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Meloxicam

About Meloxicam
NSAID, Thiazole derivative, Oxicam class, Analgesic,anti-inflammatory.
Mechanism of Action of Meloxicam
This drug reduces the prostaglandin synthesis peripherally by inhibiting COX1 & COX2 isoenzymes. This results its antinflammatory action. It is a preferential COX2 inhibitor. It also inhibits TXA2 production.
Pharmacokinets of Meloxicam
Absorption- Well absorbed after administration.
Distribution- Drug is distributed widely in the plasma-protein bound form.99.4% bound to the plasma proteins.
Metabolism- Metabolized in the liver to its metabolites. The major metabolite 5`-carboxy meloxicam.
Excretion- Excreted through urine and faeces.
Onset of Action for Meloxicam
5 to 6 hrs.
Duration of Action for Meloxicam
20 hrs.
Half Life of Meloxicam
N/A
Side Effects of Meloxicam
1. Diarrhea
2. Constipation
3. Sore throat
4. Cough
5. Runny nose
6. Fever
7. Blisters
8. Hives
9. Itching
10. Swelling of the eyes, face, tongue, lips, throat, arms, hands, feet, ankles, or lower legs
11. Difficulty breathing or swallowing
12. Hoarseness
13. Pale skin
14. Fast heartbeat
15. Weight gain
16. Upset stomach
17. Tiredness
18. Pain in the right upper part of the stomach
19. Flu-like symptoms
20. Cloudy, discolored, or bloody urine
21. Back pain
22. Difficult or painful urination
Contra-indications of Meloxicam
1. Hypersensitivity to the drug
2. Hyper sensitivity to aspirin and other NSAID
3. Active peptic ulcer
4. Renal failure
5. Hepatic failure
6. Bleeding disorder
Special Precautions while taking Meloxicam
1. Alcohol abuse
2. Bleeding problems
3. Stomach ulcer
4. Tobacco abuse
5. Anemia
6. Asthma
7. Dehydration
8. Fluid retention (swelling of feet or lower legs)
9. High blood pressure
10. Kidney disease
11. Liver disease
12. Coronary artery bypass graft (CABG) surgery
13. Heart disease
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Meloxicam
1. Rheumatoid arthritis
2. Osteoarthritis
3. Ankylosing spondylitis
4. Acute gout
Interactions for Meloxicam
No known interactions.
Typical Dosage for Meloxicam
Oral-
Adults (from 15 years) -
15mg or 7.5mg (in dialysis patients).
Schedule of Meloxicam
N/A
Storage Requirements for Meloxicam
Store it at room temperature and away from excess heat and moisture. Keep out of the reach of children.
Effects of Missed Dosage of Meloxicam
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Meloxicam
Give symptomatic and supportive treatment. Induce gastric emesis and administer activated charcoal to reduce further adsorption of drugs.

Paracetamol

About Paracetamol
Acetanilide derivative, Non narcotic Analgesic,Antipyretic.
Mechanism of Action of Paracetamol
Paracetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of Paracetamol
Absorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol
30 - 60 minutes
Duration of Action for Paracetamol
6 hours
Half Life of Paracetamol
1-4 hours
Side Effects of Paracetamol
1. Nausea
2. Abdominal distress
3. Allergic reactions
4. Rash
Contra-indications of Paracetamol
1. Hypersensitivity to Paracetamol
Special Precautions while taking Paracetamol
1. Hepatic impairment
2. Renal impairment
3. Hypertension
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES : Contraindicated
Indications for Paracetamol
1. To relieve pain and fever
2. Acute gout
3. Migraine
Interactions for Paracetamol
Cholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.
Typical Dosage for Paracetamol
Adult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Schedule of Paracetamol
H
Storage Requirements for Paracetamol
Store at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.
Effects of Missed Dosage of Paracetamol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Paracetamol
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.

Home Delivery for Meloxicam + Paracetamol in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for meloxicam + paracetamol and other medicines and health products. Home delivery services for meloxicam + paracetamol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

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Meloxicam + Paracetamol is a generic medicine name and there are several brands available for it. Some of the brands for meloxicam + paracetamol might be better known than meloxicam + paracetamol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have meloxicam + paracetamol in stock, you can ask for one of the branded alternatives for meloxicam + paracetamol.