Glycerine + Vitamin C Pharmacology

Glycerine + Vitamin C

About Glycerine + Vitamin C
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Mechanism of Action of Glycerine + Vitamin C
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Pharmacokinets of Glycerine + Vitamin C
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Onset of Action for Glycerine + Vitamin C
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Duration of Action for Glycerine + Vitamin C
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Half Life of Glycerine + Vitamin C
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Side Effects of Glycerine + Vitamin C
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Contra-indications of Glycerine + Vitamin C
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Special Precautions while taking Glycerine + Vitamin C
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Glycerine + Vitamin C
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Interactions for Glycerine + Vitamin C
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Typical Dosage for Glycerine + Vitamin C
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Schedule of Glycerine + Vitamin C
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Storage Requirements for Glycerine + Vitamin C
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Effects of Missed Dosage of Glycerine + Vitamin C
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Effects of Overdose of Glycerine + Vitamin C
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Glycerine

About Glycerine
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Mechanism of Action of Glycerine
Glycerine is a sweet clear viscous liquid with dehydrating property. It produces a warm sensation and irritates mucous membranes. When used as a suppository and applied to anal canal it induces evacuation. Glycerine soothes the irritated skin so it is used as a component of cough mixtures. When a 50% solution of Glycerine in water is applied to dry and chapped skin it acts as an emollient. When used a 10% solution I.V. it reduces intraocular or intracranial pressure. When used as a diuretic it significantly increases the osmolality of plasma and tubular fluid. It is pharmacologically inert and freely filtered at glomerulus and undergoes limited reabsorption by renal tubule and acts as osmotic diuretic.
Pharmacokinets of Glycerine
Absorption: Well absorbed orally.
Metabolism: Metabolized in the liver, kidney, and other tissues.
Excretion: Excreted through urine.
Onset of Action for Glycerine
N/A
Duration of Action for Glycerine
N/A
Half Life of Glycerine
30 to 45 minutes.
Side Effects of Glycerine
Oral administration :
1.Nausea
2.Vomiting
3.Headache
4.Confusion
5.Disorientation
6.Dehydration
7.Amnesia in elderly people
Rectal administration :
1. Griping
2. Diarrhea
3. Nausea
4. Vomiting
5. Perianal irritation
6. Abdominal cramps
7. Weakness
8. Dizziness
9. Syncope
Ophthalmic administration :
1. Irritation
2. Pain
Contra-indications of Glycerine
Oral Glycerine is contraindicated in :-
1. Hypersensitivity to Glycerine
2. Severe dehydration
3. Anuria
4. Congestive heart failure
5. Pulmonary edema
6. Hypervolemia
Rectal administration is contraindicated in:-
1. Signs of appendicitis
2. Acute surgical abdomen
3. Fecal impaction
4. Intestinal obstruction
5. Undiagnosed abdominal pain
Special Precautions while taking Glycerine
1. Confused mental states
2. Diabetes
3. Cardiac disease
4. Renal impairment
5. Hepatic impairment
6. Hemolytic anemia
7. While using oral glycerol drink plenty of fluid concomitantly
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Contraindicated
Children Related Information
May be used
Indications for Glycerine
1. As an ingredient of cough mixtures
2. As osmotic diuretic
3. As Emollient
4. Constipation
4. To reduce intraocular or intracranial tension
5. Glaucoma
Interactions for Glycerine
N/A
Typical Dosage for Glycerine
Oral:
As osmotic diuretic: 1.5g/kg as oral solution.
Topical:
Emollient: Apply a 50% solution over dry and chapped skin
Orally or per Rectum:
For evacuation: 50 to 75% Glycerine per rectum or orally.
Adults and children > 6 years: Insert 1 suppository; high in the rectum and retain for 15 minutes. Alternatively, 5-15 ml can be used as an enema.
Children < 6 years: Insert 1 infant suppository 1-2 times daily as needed. Alternatively, 2-5 ml as an enema may be used.
Neonates: 0.5 ml/kg/dose as an enema.
I.V.:
To reduce intraocular or intracranial tension: 10% Glycerine intravenously.
Oral: 1 to 1.8g/kg orally. Additional doses may be administered at 5 hour intervals. If used prior to ocular surgery, dosing should begin 1-1.5 hours before the procedure
For use during ophthalmic examination:
Adults: Instill 1 or 2 drops of Ophthalmic dosage prior to examination of edematous cornea.
Schedule of Glycerine
N/A
Storage Requirements for Glycerine
Store at room temperature at a range of 15 to 30 degree C in a well closed container. Protect from direct sunlight and moisture. Avoid metal containers and contact with strong oxidizing agents.
Effects of Missed Dosage of Glycerine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Glycerine
Give supportive measures and symptomatic treatment.

Vitamin C

About Vitamin C
Water soluble vitamin, antioxidant.
Mechanism of Action of Vitamin C
Vitamin C exerts it`s action by influencing the biologic oxidations and reductions used in cellular respirations. It directly stimulates collagen synthesis and maintains intracellular connective tissue. It involves in various metabolic reactions such as 1).Hydroxylation of praline and lysine residues of protocollagen which is essential for formation and stabilization of collagen triple helix, 2).hydroxylation of carnitine, 3).Conversion of folic acid to folinic acid, 4).biosynthesis of adrenal steroids, catecholamines, oxytocin, and ADH, 5).Metabolism of cyclic nucleotides and prostaglandins. Vitamin C is important in resistance to infections.
Pharmacokinets of Vitamin C
Absorption: Well absorbed orally.
Distribution: Widely distributed both extracellularly and intracellularly, It crosses the placenta and also distributed in to the breast milk.
Metabolism: Metabolized in the liver; partly oxidized in to active dehydroascorbic acid and inactive metabolites.
Excretion: Inactive metabolites and extra drug is excreted through urine.
Onset of Action for Vitamin C
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Duration of Action for Vitamin C
N/A
Half Life of Vitamin C
N/A
Side Effects of Vitamin C
1. Discomfort at injection site
2. Acid urine
3. Renal calculi
4. Oxaluria
Contra-indications of Vitamin C
No known contraindications
Special Precautions while taking Vitamin C
1. Renal impairment
2. Ingestion of large doses during pregnancy has resulted in scurvy in neonates
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
May be used
Indications for Vitamin C
1. Scurvy
2. Prophylaxis and treatment of vitamin C deficiency
3. As an antioxidant to maintain natural colour and flavour of food items
4. For acidification of urine
5. Capillary fragility
6. Dental caries

Interactions for Vitamin C
Oral contraceptives and estrogens: Vitamin C increases serum levels of oestrogen resulting in adverse reactions .
Warfarin: The anticoagulant effects of warfarin is reduced.
Lab Tests: Large doses (>500 mg) of vitamin C may cause false negative urine glucose determinations. May result in false negative amine dependent stool occult blood tests.
Typical Dosage for Vitamin C
Oral:
Adults: 50 to 1000mg/day depending up on the requirement.
Pregnancy and lactation: 100 to 150mg/day
Children: 30 to 100mg/day.
Scurvy:
Oral:
Adults: 1000mg twice daily to thrice daily.
Children: 300mg to 1000mg daily.
Sub clinical scurvy:
Oral, S.C., I.M., or I.V.: 100 to 250mg once daily or twice daily depending up on the severity of the condition. Then give a maintenance dosage of 50mg/day.
Children: 100 to 300mg depending up on the severity. Then give a maintenance dose of 35mg/day.

Schedule of Vitamin C
C1 (Oral)
C (Parenteral)
Storage Requirements for Vitamin C
Store in a cool dry area in a well closed container. Protects from moisture, light and direct heat.
Effects of Missed Dosage of Vitamin C
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Vitamin C
Discontinue the therapy and provide symptomatic and supportive measures.

Home Delivery for Glycerine + Vitamin C in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for glycerine + vitamin c and other medicines and health products. Home delivery services for glycerine + vitamin c may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take glycerine + vitamin c only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for glycerine + vitamin c before they complete the sale. You can get this information while placing the order for glycerine + vitamin c with the pharmacy.

Glycerine + Vitamin C is a generic medicine name and there are several brands available for it. Some of the brands for glycerine + vitamin c might be better known than glycerine + vitamin c itself. If the pharmacy that's willing to deliver medicines to your home doesn't have glycerine + vitamin c in stock, you can ask for one of the branded alternatives for glycerine + vitamin c.