Acitretin Pharmacology

Acitretin

About Acitretin
Retinoid-Like Compound, Antipsoriatic.
Mechanism of Action of Acitretin
Acitretin is a second generation retinoid. It slows down the proliferation of the skin cells and is therefore used in psoriasis. Retinoic acid activates Retinoic acid receptors (RARs) and retinoic acid X receptors (RXRs) and produce effects on gene expression. Retinoid binds to transcription factors (nuclear receptors) and form complex. This complex binds to promoter regions of target genes and regulates their expressions. The gene product formed produce effective pharmacological actions.
Pharmacokinets of Acitretin
N/A
Onset of Action for Acitretin
N/A
Duration of Action for Acitretin
N/A
Half Life of Acitretin
N/A
Side Effects of Acitretin
1.Dry mouth
2.Abdominal disturbances
3.Vomiting
4.Nausea
5.Headache
6.Shortness of breath
7.Decreased consciousness
8.Dryness of lips
9.Dry nostrils
10.Dry eyes
11.Dry reddened skin
12.Drowsiness
13.Peeling skin
14.Dry skin
15.Malaise
16.Weak nails
17.Dandruff
18.Sunburn
19.Abnormal skin odor
20.Excessive sweating
21.Hair loss
22.Changes in hair texture
23.Dry eyes
24.Loss of eyebrows or eyelashes
25.Hot flashes
26.Swollen lips
27.Bleeding gums
28.Excessive saliva
29.Mouth swelling
30.Stomach pain
31.Diarrhoea
32.Increased appetite
33.Sleep
34.Sinusitis
35.Rhinitis
36.Nosebleed
37.Joint pain
38.Tight muscles

Contra-indications of Acitretin
1.Hepatic impairment
2.Renal impairment
3.Hyperlipidaemia
Special Precautions while taking Acitretin
1.Diabetes
2.Avoid excessive exposure to sunlight
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Acitretin
1.Psoriasis
2.Darier`s disease
3.Ichthyosis
4.Impetigo
Interactions for Acitretin
N/A
Typical Dosage for Acitretin
Adult: 25- 30mg / day for 14 - 28 days, then adjusted according to response. Maintenance dose: 25 - 50mg/day.
Maximum dose: 75mg/day
Darier`s disease: 10mg/day
Children: 0.5 mg/kg daily dose can be increased to 1mg/kg daily.
Schedule of Acitretin
H
Storage Requirements for Acitretin
Store it at room temperature and away from excess heat and moisture. Keep out of reach of children.
Effects of Missed Dosage of Acitretin
Take the missed dose as soon as noticed and if it is the time to next dose then skip the missed dose. Continue the regular dose. Do not double the dose.
Effects of Overdose of Acitretin
Give supportive measures and symptomatic treatment.

Home Delivery for Acitretin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including acitretin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for acitretin and other medicines and health products. Home delivery services for acitretin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take acitretin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for acitretin before they complete the sale. You can get this information while placing the order for acitretin with the pharmacy.

Acitretin is a generic medicine name and there are several brands available for it. Some of the brands for acitretin might be better known than acitretin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have acitretin in stock, you can ask for one of the branded alternatives for acitretin.