Beclomethasone dipropionate Pharmacology

Beclomethasone dipropionate

About Beclomethasone dipropionate
Potent glucocorticoid, Potent anti-inflammatory agent in respiratory tract and nasal passages.
Mechanism of Action of Beclomethasone dipropionate
Mechanism of action: The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits Phospholipase A2 and thus decreases the production of Prostaglandins, leukotrienes (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.

Pharmacokinets of Beclomethasone dipropionate
Absorption: It enters in to the systemic circulation after topical administration.
Onset of Action for Beclomethasone dipropionate
Duration of Action for Beclomethasone dipropionate
Half Life of Beclomethasone dipropionate
Side Effects of Beclomethasone dipropionate
1.Thinning of the skin
2.Loss of elasticity
3.Increased hair growth
4.Acne at the site of application
5.Mild depigmentation
Contra-indications of Beclomethasone dipropionate
1.Hypersensitivity to Beclomethasone
2.Untreated bacterial virus or fungal infections
3.Acne vulgaris
4.Peri-oral dermatitis
5.Tuberculosis of the skin
6.Varicose ulcers
7.Skin lesions caused by infections with herpes simplex vaccinia or varicella viruses. fungi (e.g. Candida Tinea) or bacteria (e.g. impetigo)
8.Discoid lupus Erythematosus
Special Precautions while taking Beclomethasone dipropionate
1.Avoid contact with eyes
2.For external use only
3.Prolonged use
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Beclomethasone dipropionate
3.Contact dermatitis
4.Anal and vulval Pruritis
5.Inflammation of the skin
Interactions for Beclomethasone dipropionate
There are no known drug interactions with topical betamethasone dipropionate.
Typical Dosage for Beclomethasone dipropionate
Topical: Apply 0.025 %w/w cream as thin film 1 - 2times daily on to the affected area
Schedule of Beclomethasone dipropionate
Storage Requirements for Beclomethasone dipropionate
Store below 25 degree C in a tightly closed container. Keep out of the reach of children
Effects of Missed Dosage of Beclomethasone dipropionate
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Beclomethasone dipropionate
Give supportive measures and symptomatic treatment.

Home Delivery for Beclomethasone dipropionate in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for beclomethasone dipropionate and other medicines and health products. Home delivery services for beclomethasone dipropionate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take beclomethasone dipropionate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for beclomethasone dipropionate before they complete the sale. You can get this information while placing the order for beclomethasone dipropionate with the pharmacy.

Beclomethasone dipropionate is a generic medicine name and there are several brands available for it. Some of the brands for beclomethasone dipropionate might be better known than beclomethasone dipropionate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have beclomethasone dipropionate in stock, you can ask for one of the branded alternatives for beclomethasone dipropionate.