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- Pharmacology For Fluticasone + Mupirocin
Fluticasone + Mupirocin Pharmacology
Fluticasone + Mupirocin
About Fluticasone + MupirocinN/AMechanism of Action of Fluticasone + MupirocinN/APharmacokinets of Fluticasone + MupirocinN/AOnset of Action for Fluticasone + MupirocinN/ADuration of Action for Fluticasone + MupirocinN/AHalf Life of Fluticasone + MupirocinN/ASide Effects of Fluticasone + MupirocinN/AContra-indications of Fluticasone + MupirocinN/ASpecial Precautions while taking Fluticasone + MupirocinN/APregnancy Related InformationUse with caution; since Fluticasone and Mupirocin are used with caution in pregnancyOld Age Related InformationN/ABreast Feeding Related InformationUse with caution; since Fluticasone and Mupirocin are used with caution in lactationChildren Related InformationN/AIndications for Fluticasone + MupirocinAtopic dermatitisInteractions for Fluticasone + MupirocinN/ATypical Dosage for Fluticasone + MupirocinApply the medicament twice daily for 2 weeksSchedule of Fluticasone + MupirocinN/AStorage Requirements for Fluticasone + MupirocinN/AEffects of Missed Dosage of Fluticasone + MupirocinN/AEffects of Overdose of Fluticasone + MupirocinN/AFluticasone
About FluticasoneSynthetic topical glucocorticoid, Anti inflammatory and antipruritic in corticosteroid-responsive dermatoses; atopic dermatitis.Mechanism of Action of FluticasoneIt reduces prostaglandin synthesis by inhibiting cyclo oxygenase enzymes both COX1 and COX2.In higher doses it reduces the thromboxane A2 synthesis by COX1 inhibition. So platelet aggregation is inhibited by this drug. After topical application in the case of ophthalmic preparation it prevents miosis by reducing ocular prostaglandins synthesis. It is a phenylalkalonic acid derivative Non Steroidal Anti Inflammatory Drug.
Pharmacokinets of FluticasoneAbsorption- Well absorbed orally.
Distribution-99% bound to the plasma proteins.
Metabolism- In liver it is metabolized by hydroxylation and conjugation.
Excretion-It is excreted through urine.
Onset of Action for Fluticasone30-60minDuration of Action for Fluticasone8-12hrsHalf Life of Fluticasone6-10 hrsSide Effects of Fluticasone1. Anxiety
2. Insomnia
3. Tremors
4. Depression
5. Heart failure
6. Visual changes
7. Renal failure
8. Thrombocytopenia
9. Aplastic anemia
10. Photosensitivity
11. Urticaria
12. Angioedema
Contra-indications of Fluticasone1. Hypersensitivity to this drug
2. Peptic ulcer
3. Gastro intestinal bleeding
4. Bronchospasm
5. Hypersensitivity
6. Herpes simplex keratitis
Special Precautions while taking Fluticasone1. Renal failure
2. Hyper tension
3. Hypersensitive to other Non Steroidal Anti Inflammatory Drugs
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution.
NEONATES: contraindicatedIndications for Fluticasone1. Rheumatoid arthritis
2. Osteo arthritis
3. Ankylosing spondylitis
4. Pain in patients with dysmenorrhea.
5. Post operative inflammation of the eye.
6. Migraine
7. Acute gout
Interactions for FluticasoneNone reported.
Typical Dosage for FluticasoneOral
Adults- 200-300mg/day in 2-4 divided doses.
Topicaly-0.03% ophthalmic solution. Add 1 drop in every ? hr to the eyes beginning 2-3 hrs before surgery.
Schedule of FluticasoneHStorage Requirements for FluticasoneStore in a sealed container at room a temperature and avoid moisture.
In the case of ophthalmic preparation stored between 15 and 30 degree Celsius.
Effects of Missed Dosage of FluticasoneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of FluticasoneSupportive and symptomatic treatment should be given. Empty the stomach by emesis or gastric lavage. Mupirocin
About MupirocinA naturally antibiotic isolated from Pseudomonas fluorescens, Antibiotic.Mechanism of Action of MupirocinMupirocin exerts its action by reversibly binding to isoleucyl transfer RNA synthetase and inhibits the enzyme activity. This enzyme is necessary for the synthesis of proteins in the bacteria. Inhibition of isoleucyl transfer RNA synthetase results in inhibition of protein synthesis and produce microbicidal action. It is more active against gram positive bacteria as compared to gram negative bacteria.Pharmacokinets of MupirocinAbsorption: Mupirocin is negligibly absorbed after topical administration.Onset of Action for MupirocinN/ADuration of Action for MupirocinN/AHalf Life of MupirocinN/ASide Effects of MupirocinTopical use :
1. Irritation
2. Burning
3. Rashes
4. Pruritis
5. Stinging
6. Erythema
7. Dryness
8. Dermatitis
9. Pain
Nasal use:
1. Rhinitis
2. Cough
3. Headache
4. Pharyngitis
5. Change in taste
6. Chest congestion
Contra-indications of Mupirocin1. Hypersensitivity to MupirocinSpecial Precautions while taking Mupirocin1. If sensitivity occurs discard the use of the medicament
2. Renal impairment
3. Patient with burns
4. Avoid contact with eyes and mucous membrane
5. Avoid application in the large surface area(extensive wound)
6. Monitor for super infection
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Use with cautionIndications for MupirocinBacterial skin infections:
1. Impetigo
2. Infected eczema
3. Folliculitis
4. Eradication of nasal colonization of Methicillin resistant S.aureus
Interactions for MupirocinN/ATypical Dosage for MupirocinAdult:
Topical use: 2% cream, and ointment: Wash and dry the affected area thoroughly. Apply the medicament as a thin film over the affected part. Rub gently. Cover with a surgical gauze. Apply 3 times daily for 1 - 2 weeks.
Intranasal use: 2 % ointment: Apply the half of the content of a single use tube in to one nostril and other half in to other nostril. Press the sides of the nostrils together and release it. Repeat it for 1 minute. Apply it morning and evening.
Schedule of MupirocinN/AStorage Requirements for MupirocinStore at room temperature in a tightly closed container. Keep away from moisture and heat. Keep out of the reach of children.Effects of Missed Dosage of MupirocinApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of MupirocinGive supportive measures and symptomatic treatment.Home Delivery for Fluticasone + Mupirocin in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including fluticasone + mupirocin.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for fluticasone + mupirocin and other medicines and health products. Home delivery services for fluticasone + mupirocin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take fluticasone + mupirocin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for fluticasone + mupirocin before they complete the sale. You can get this information while placing the order for fluticasone + mupirocin with the pharmacy.
Fluticasone + Mupirocin is a generic medicine name and there are several brands available for it. Some of the brands for fluticasone + mupirocin might be better known than fluticasone + mupirocin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have fluticasone + mupirocin in stock, you can ask for one of the branded alternatives for fluticasone + mupirocin.
