Rofecoxib Pharmacology

Rofecoxib

About Rofecoxib
NSAID,Selective COX-2 inhibitor, Analgesic ,anti-inflammatory.
Mechanism of Action of Rofecoxib
Rofecoxib inhibits prostaglandin synthesis by inhibiting COX2 enzyme. This NSAID inhibit COX2 enzyme selectively (COX-2 is only produced in response to tissue injury and causes tissue inflammation, and thus pain. It works converting arachidonic acid into a specific prostaglandin which communicates the need for inflammation to the surrounding tissue). This results the anti-inflammatory action
Pharmacokinets of Rofecoxib
Absorption- Well absorbed after oral administration
Distribution- Widely distributed in the body as its plasma protein bound form. Metabolism-It is metabolized in the liver to inactive metabolites.Excretion- Excreted through urine
Onset of Action for Rofecoxib
N/A
Duration of Action for Rofecoxib
N/A
Half Life of Rofecoxib
17 hours
Side Effects of Rofecoxib
. Diarrhea
2. Constipation
3. Sore throat
4. Cough
5. Runny nose
6. Fever
7. Blisters
8. Hives
9. Itching
10. Swelling
11. Difficulty in breathing or swallowing
12. Hoarseness
13. Pale skin
14. Fast heartbeat
15. Weight gain
16. Upset stomach
17. Tiredness
18. Pain in the right upper part of the stomach
19. Flu-like symptoms
20. Cloudy, discolored, or bloody urine
21. Back pain
22. Difficult or painful urination
Contra-indications of Rofecoxib
1. Hypersensitivity to the drug.
2. Hepatic insufficiency.
3. Renal insufficiency
Special Precautions while taking Rofecoxib
1. Alcohol abuse
2. Bleeding problems
3. Stomach ulcer
4. Tobacco abuse
5. Anemia
6. Asthma
7. Dehydration
8. Fluid retention (swelling of feet or lower legs)
9. High blood pressure
10. Coronary artery bypass graft (CABG) surgery
11. Heart disease
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Rofecoxib
1. Dysmenorrhea (pain with your menstrual period)
2. Osteoarthritis
Interactions for Rofecoxib
N/A
Typical Dosage for Rofecoxib
Oral-
Adults-
Osteoarthritis: 12.5mg day and if needed dose can be increased to 25mg/day
Dysmenorrhea- 50mg/day for upto 5 days
Schedule of Rofecoxib
N/A
Storage Requirements for Rofecoxib
Store at room temperature.Keep away from moisture and heat
Effects of Missed Dosage of Rofecoxib
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Rofecoxib
Give supportive measures and symptomatic treatment.

Home Delivery for Rofecoxib in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including rofecoxib.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for rofecoxib and other medicines and health products. Home delivery services for rofecoxib may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take rofecoxib only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for rofecoxib before they complete the sale. You can get this information while placing the order for rofecoxib with the pharmacy.

Rofecoxib is a generic medicine name and there are several brands available for it. Some of the brands for rofecoxib might be better known than rofecoxib itself. If the pharmacy that's willing to deliver medicines to your home doesn't have rofecoxib in stock, you can ask for one of the branded alternatives for rofecoxib.