Valdecoxib Pharmacology


About Valdecoxib
NSAID,a COX-2 inhibitor, a diaryl substituted isoxazole, Analgesic,antiinflammatory,antiarthritic.
Mechanism of Action of Valdecoxib
This NSAID inhibit COX2 enzyme selectively (COX-2 is only produced in response to tissue injury and causes tissue inflammation, and thus pain. It works by converting arachidonic acid into a specific prostaglandin which communicates the need for inflammation to the surrounding tissue). This results the anti-inflammatory action.
Pharmacokinets of Valdecoxib
Absorption- Well absorbed after oral administration.
Distribution- Widely distributed in the body as its plasma protein bound form. 98% bound to the plasma proteins.
Metabolism-It is metabolized in the liver.
Excretion- Excreted through urine and faeces.
Onset of Action for Valdecoxib
Duration of Action for Valdecoxib
Half Life of Valdecoxib
Side Effects of Valdecoxib
1. Diarrhea
2. Constipation
3. Sore throat
4. Cough
5. Runny nose
6. Fever
7. Blisters
8. Hives
9. Itching
10. Swelling of the eyes, face, tongue, lips, throat, arms, hands, feet, ankles, or lower legs
11. Difficulty in breathing or swallowing
12. Hoarseness
13. Pale skin
14. Fast heartbeat
15. Weight gain
16. Upset stomach
17. Tiredness
18. Pain in the right upper part of the stomach
19. Flu-like symptoms
20. Cloudy, discolored, or bloody urine
21. Back pain
22. Difficult or painful urination
Contra-indications of Valdecoxib
1. Hypersensitivity to the drug
2. Hepatic insufficiency
3. Renal insufficiency
Special Precautions while taking Valdecoxib
1. Alcohol abuse
2. Bleeding problems
3. Stomach ulcer
4. Tobacco abuse
5. Anemia
6. Asthma
7. Dehydration
8. Fluid retention (swelling of feet or lower legs)
9. High blood pressure
10. Kidney disease
11. Liver disease
12. Coronary artery bypass graft (CABG) surgery
13. Heart disease
Pregnancy Related Information

Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Indications for Valdecoxib
1. Dysmenorrhea (pain with your menstrual period)
2. Osteoarthritis
3. Rheumatoid arthritis
4. Acute gout
Interactions for Valdecoxib
Coadministration with fluconazole and ketoconazole : Enhances the total plasma exposure (AUC) of valdecoxib.
Coadministration with warfarin: Causes a significant increase in plasma exposure of warfarin.
Typical Dosage for Valdecoxib
Osteoarthritis & rheumatoid arthritis - 10mg once a day.
Dysmenorrhea- 20- 40mg daily.
Schedule of Valdecoxib
Storage Requirements for Valdecoxib
Store at room temperature away from moisture and heat.
Effects of Missed Dosage of Valdecoxib
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Valdecoxib
Give symptomatic and supportive treatment. Induce gastric emesis and administer activated charcoal to reduce further adsorption of drugs.

Home Delivery for Valdecoxib in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including valdecoxib.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for valdecoxib and other medicines and health products. Home delivery services for valdecoxib may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take valdecoxib only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for valdecoxib before they complete the sale. You can get this information while placing the order for valdecoxib with the pharmacy.

Valdecoxib is a generic medicine name and there are several brands available for it. Some of the brands for valdecoxib might be better known than valdecoxib itself. If the pharmacy that's willing to deliver medicines to your home doesn't have valdecoxib in stock, you can ask for one of the branded alternatives for valdecoxib.