Beclomethasone dipropionate + Ofloxacin + Clotrimazole Pharmacology

Beclomethasone dipropionate + Ofloxacin + Clotrimazole

About Beclomethasone dipropionate + Ofloxacin + Clotrimazole
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Mechanism of Action of Beclomethasone dipropionate + Ofloxacin + Clotrimazole
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Pharmacokinets of Beclomethasone dipropionate + Ofloxacin + Clotrimazole
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Onset of Action for Beclomethasone dipropionate + Ofloxacin + Clotrimazole
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Duration of Action for Beclomethasone dipropionate + Ofloxacin + Clotrimazole
N/A
Half Life of Beclomethasone dipropionate + Ofloxacin + Clotrimazole
N/A
Side Effects of Beclomethasone dipropionate + Ofloxacin + Clotrimazole
N/A
Contra-indications of Beclomethasone dipropionate + Ofloxacin + Clotrimazole
N/A
Special Precautions while taking Beclomethasone dipropionate + Ofloxacin + Clotrimazole
N/A
Pregnancy Related Information
Contraindicated; since Ofloxacin is contraindicated in pregnancy, the combination generic cannot be used in pregnancy.
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated; since Ofloxacin is contraindicated in breast feeding, the combination generic cannot be used in breast feeding mother
Children Related Information
N/A
Indications for Beclomethasone dipropionate + Ofloxacin + Clotrimazole
1.Fungal infection of ear(otitis externa)
Interactions for Beclomethasone dipropionate + Ofloxacin + Clotrimazole
N/A
Typical Dosage for Beclomethasone dipropionate + Ofloxacin + Clotrimazole
Apply 2 -3 drop in to the ear 2 - 3 times daily.
Schedule of Beclomethasone dipropionate + Ofloxacin + Clotrimazole
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Storage Requirements for Beclomethasone dipropionate + Ofloxacin + Clotrimazole
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Effects of Missed Dosage of Beclomethasone dipropionate + Ofloxacin + Clotrimazole
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Effects of Overdose of Beclomethasone dipropionate + Ofloxacin + Clotrimazole
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Beclomethasone dipropionate

About Beclomethasone dipropionate
Potent glucocorticoid, Potent anti-inflammatory agent in respiratory tract and nasal passages.
Mechanism of Action of Beclomethasone dipropionate
Mechanism of action: The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits Phospholipase A2 and thus decreases the production of Prostaglandins, leukotrienes (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.


Pharmacokinets of Beclomethasone dipropionate
Absorption: It enters in to the systemic circulation after topical administration.
Onset of Action for Beclomethasone dipropionate
N/A
Duration of Action for Beclomethasone dipropionate
N/A
Half Life of Beclomethasone dipropionate
N/A
Side Effects of Beclomethasone dipropionate
1.Thinning of the skin
2.Loss of elasticity
3.Increased hair growth
4.Acne at the site of application
5.Mild depigmentation
6.Rosacea
Contra-indications of Beclomethasone dipropionate
1.Hypersensitivity to Beclomethasone
2.Untreated bacterial virus or fungal infections
3.Acne vulgaris
4.Peri-oral dermatitis
5.Tuberculosis of the skin
6.Varicose ulcers
7.Skin lesions caused by infections with herpes simplex vaccinia or varicella viruses. fungi (e.g. Candida Tinea) or bacteria (e.g. impetigo)
8.Discoid lupus Erythematosus
Special Precautions while taking Beclomethasone dipropionate
1.Avoid contact with eyes
2.For external use only
3.Prolonged use
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Beclomethasone dipropionate
1.Eczema
2.Psoriasis
3.Contact dermatitis
4.Anal and vulval Pruritis
5.Inflammation of the skin
Interactions for Beclomethasone dipropionate
There are no known drug interactions with topical betamethasone dipropionate.
Typical Dosage for Beclomethasone dipropionate
Topical: Apply 0.025 %w/w cream as thin film 1 - 2times daily on to the affected area
Schedule of Beclomethasone dipropionate
H
Storage Requirements for Beclomethasone dipropionate
Store below 25 degree C in a tightly closed container. Keep out of the reach of children
Effects of Missed Dosage of Beclomethasone dipropionate
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Beclomethasone dipropionate
Give supportive measures and symptomatic treatment.

Ofloxacin

About Ofloxacin
A second generation fluoroquinolone(quinolones), Antibiotic.
Mechanism of Action of Ofloxacin
Ofloxacin is a bactericidal drug. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Ofloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.
Pharmacokinets of Ofloxacin
Absorption: Ofloxacin is rapidly and completely absorbed after oral administration.
Distribution: It is widely distributed in the body.
Metabolism: It undergoes insignificant metabolism.
Excretion: Drug is excreted mainly through urine.
Onset of Action for Ofloxacin
With in 0.5 hour
Duration of Action for Ofloxacin
12 - 16 hours
Half Life of Ofloxacin
5 - 8 hours
Side Effects of Ofloxacin
1. Nausea
2. Vomiting
3. Diarrhoea
4. Abdominal discomfort
5. Constipation
6. Dry mouth
7. Dizziness
8. Headache
9. Rash
10. Pruritis
11. Pseudomembranous colitis
12. Visual disturbances
13. Insomnia
Contra-indications of Ofloxacin
1. Hypersensitivity to Ofloxacin and other Fluoroquinolones
Special Precautions while taking Ofloxacin
1. Hepatic impairment
2. Renal impairment
3. Cerebral arteriosclerosis
4. Epilepsy
5. CNS disease
6. Avoid exposure to sunlight
7. Caution while driving the vehicle or operating machine or involved in any hazardous activities.

Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
NEONATES : Contraindicated

Indications for Ofloxacin
1. Bronchitis
2. Pneumonia
3. Urinary tract infection
4. Bone and joint infections
5. Intra-abdominal infections
6. Gonorrhoea
7. ENT infections
8. Skin and soft tissue infections
9. Typhoid fever
10. Prostatis
11. Otitis
12. Gynaecological infections
13. Conjunctivitis
14. Keratitis
15. Urethritis
16. Cervicitis
Interactions for Ofloxacin
Oral Anticoagulants: The effects of oral anticoagulants, may be increased.
Theophylline: Increased plasma levels of theophylline resulting in toxicity.
NSAID`s: CNS excitation may occur.
Typical Dosage for Ofloxacin
Adults: 200 - 400 mg / day depending on the severity and type of infection
Bronchitis, Pneumonia, Skin and soft tissue infections: 800 mg / day in 2 divided doses for 10 days
Gonorrhoea: 400 mg as a single dose.
Prostatis, Cervicitis & Urethritis: 600 mg / day in 2 divided doses for 1 week.
UTI: 200 - 800 mg / day in single or divided doses
Typhoid fever: 400 - 800 mg / day in 2 divided doses

Schedule of Ofloxacin
H
Storage Requirements for Ofloxacin
Store at 15 - 30 degree C in a tightly closed container.
Effects of Missed Dosage of Ofloxacin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.
Effects of Overdose of Ofloxacin
Give supportive measures and symptomatic treatment. Gastric lavage has to be done.

Clotrimazole

About Clotrimazole
A broad-spectrum antifungal antibiotic, imidazole derivative, Oral Nonabsorbed Antifungal Agent.
Mechanism of Action of Clotrimazole
Clotrimazole is fungicidal or fungistatic depending on the drug concentrations. It inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesis which is an essential constituent of cell membrane. Inhibition of ergosterol synthesis will alter the membrane permeability of the susceptible fungus and kill or inhibit them.
Pharmacokinets of Clotrimazole
Absorption: Absorption is minimal after topical administration.
Onset of Action for Clotrimazole
N/A
Duration of Action for Clotrimazole
3 hours
Half Life of Clotrimazole
N/A
Side Effects of Clotrimazole
1.Stinging
2.Erythema
3.Burning
4.Pruritis
5.Vesication
6.Desquamation
7.Urticaria
8.Burning
9.Peeling
10.Irritation
Contra-indications of Clotrimazole
Hypersensitivity to Clotrimazole
Special Precautions while taking Clotrimazole
1.Avoid contact with eyes, nose and mouth.
2.Do not wear occlusive dress over the medicament.
Pregnancy Related Information
Use with caution.
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Use with caution.
Children Related Information
Use with caution.
NEONATES: contraindicated
Indications for Clotrimazole
1.Tinea pedis
2.Tinea cruris
3.Tinea versicolor
4.Tinea corporis
5.Cutaneous candidiasis
6.Vulvovaginal candidiasis
Interactions for Clotrimazole
Polyene Antibiotics : Antagonises effects of polyene antibiotics.
Typical Dosage for Clotrimazole
Topical: Clotrimazole cream, lotion and solution 1 % is used.
Clean and dry the affected area and apply the medicament with gentle massage 2 -3 times daily for 2 - 4 weeks.
Vaginal candidiasis: Insert 1 applicator full (vaginal cream 1%) intravaginally at night for 1 -2 weeks.
Vaginal tablets 100. 200 and 500mg tablet is available.
Vulvovaginal candidiasis: Insert 100mg tablet intravaginally at bed time for 7 consecutive days or 200 mg tablet for 3 consecutive days or 500 mg tablet for 1 day at night.
Oral lozenge 10 mg is available
Oropharyngeal candidiasis: 1 lozenge orally 5 times daily for 2 weeks
Prophylaxis of Oropharyngeal candidiasis: 1 lozenge is used 3 times daily
Gel: Insert with an applicator intravaginally at night for 1 - 2 weeks.
Powder (1% w/ w): dusted over the body parts as required
Schedule of Clotrimazole
H
Storage Requirements for Clotrimazole
Store at room temperature (15 - 25 degree C). Protect from heat and moisture. Keep out of the reach of children
Effects of Missed Dosage of Clotrimazole
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Clotrimazole
Give supportive measures and symptomatic treatment.

Home Delivery for Beclomethasone dipropionate + Ofloxacin + Clotrimazole in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for beclomethasone dipropionate + ofloxacin + clotrimazole and other medicines and health products. Home delivery services for beclomethasone dipropionate + ofloxacin + clotrimazole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take beclomethasone dipropionate + ofloxacin + clotrimazole only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for beclomethasone dipropionate + ofloxacin + clotrimazole before they complete the sale. You can get this information while placing the order for beclomethasone dipropionate + ofloxacin + clotrimazole with the pharmacy.

Beclomethasone dipropionate + Ofloxacin + Clotrimazole is a generic medicine name and there are several brands available for it. Some of the brands for beclomethasone dipropionate + ofloxacin + clotrimazole might be better known than beclomethasone dipropionate + ofloxacin + clotrimazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have beclomethasone dipropionate + ofloxacin + clotrimazole in stock, you can ask for one of the branded alternatives for beclomethasone dipropionate + ofloxacin + clotrimazole.