Xylometazoline Pharmacology


About Xylometazoline
Imidazoline derivative,Alpha-2 adrenergic agonist, Topical nasal decongestant.
Mechanism of Action of Xylometazoline
It is a nasal decongestant with selective alpha-2 agonistic action. It produces local vasoconstriction, reduces blood flow, and causes shrinkage of mucosa which provides relief of nasal congestion.
Pharmacokinets of Xylometazoline
Absorption: Administered intranasally
Onset of Action for Xylometazoline
Nasal: 5 to 10 minutes
Duration of Action for Xylometazoline
Nasal: 5 to 6 hours
Half Life of Xylometazoline
Side Effects of Xylometazoline
1. Dryness of nose and throat
2. Irritation
3. Burning sensation
4. Stinging
5. Sneezing
6. Rebound congestion
7. Hypertension
Contra-indications of Xylometazoline
1. Hypersensitivity to the drug
2. Glaucoma
Special Precautions while taking Xylometazoline
1. Type 2 diabetes mellitus
2. Dry membranes in nose
3. Enlarged prostate
4. Crdiovascular diseases
5 Hyperthyroidism
6. Hypertension
7. Along with MAO inhibitors
9. 0. 1% solution is contraindicated in children
10. Avoid prolonged use
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Xylometazoline
1. Nasal congestion
Interactions for Xylometazoline
Tricyclic antidepressants: Xylometazoline may potentiate the pressor effects of tricyclic antidepressants.
Typical Dosage for Xylometazoline
Adults and children over 12 years: Apply 2 to 3 drops or sprays of 0.1% solution in each nostril every 8 to 10 hours. Should not use; more than 3 times in 24 hours.
Children: Apply 2 to 3 drops of 0.05% solution in each nostril every 8 to 10 hours. Should not use; more than 3 times in 24 hours
Infants: Apply 1 drop of 0.05% solution in each nostril every 8 to 10 hours as required; under medical supervision
Schedule of Xylometazoline
Storage Requirements for Xylometazoline
Store at room temperature at a range of 15 to 300C. Protect from direct heat and light. Avoid freezing. Keep out of reach of children.
Effects of Missed Dosage of Xylometazoline
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Xylometazoline
Over dosage and poisoning: Provide supportive treatment and symptomatic measures.

Home Delivery for Xylometazoline in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including xylometazoline.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for xylometazoline and other medicines and health products. Home delivery services for xylometazoline may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take xylometazoline only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for xylometazoline before they complete the sale. You can get this information while placing the order for xylometazoline with the pharmacy.

Xylometazoline is a generic medicine name and there are several brands available for it. Some of the brands for xylometazoline might be better known than xylometazoline itself. If the pharmacy that's willing to deliver medicines to your home doesn't have xylometazoline in stock, you can ask for one of the branded alternatives for xylometazoline.