Betamethasone (Nasal) + Naphazoline + Neomycin (Nasal) Pharmacology

Betamethasone (Nasal) + Naphazoline + Neomycin (Nasal)

About Betamethasone (Nasal) + Naphazoline + Neomycin (Nasal)

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Mechanism of Action of Betamethasone (Nasal) + Naphazoline + Neomycin (Nasal)

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Pharmacokinets of Betamethasone (Nasal) + Naphazoline + Neomycin (Nasal)

N/A

Onset of Action for Betamethasone (Nasal) + Naphazoline + Neomycin (Nasal)

N/A

Duration of Action for Betamethasone (Nasal) + Naphazoline + Neomycin (Nasal)

N/A

Half Life of Betamethasone (Nasal) + Naphazoline + Neomycin (Nasal)

N/A

Side Effects of Betamethasone (Nasal) + Naphazoline + Neomycin (Nasal)

N/A

Contra-indications of Betamethasone (Nasal) + Naphazoline + Neomycin (Nasal)

N/A

Special Precautions while taking Betamethasone (Nasal) + Naphazoline + Neomycin (Nasal)

N/A

Pregnancy Related Information

Contraindicated;since Betamethasone and Neomycin are contraindicated in pregnancy

Old Age Related Information

N/A

Breast Feeding Related Information

Contraindicated;since Betamethasone and Neomycin are contraindicated in breast feeding

Children Related Information

N/A

Indications for Betamethasone (Nasal) + Naphazoline + Neomycin (Nasal)

Nasal allergy

Interactions for Betamethasone (Nasal) + Naphazoline + Neomycin (Nasal)

N/A

Typical Dosage for Betamethasone (Nasal) + Naphazoline + Neomycin (Nasal)

Instill 1 - 2 drops to the affected nose 1 - 3 times daily

Schedule of Betamethasone (Nasal) + Naphazoline + Neomycin (Nasal)

N/A

Storage Requirements for Betamethasone (Nasal) + Naphazoline + Neomycin (Nasal)

N/A

Effects of Missed Dosage of Betamethasone (Nasal) + Naphazoline + Neomycin (Nasal)

N/A

Effects of Overdose of Betamethasone (Nasal) + Naphazoline + Neomycin (Nasal)

N/A

Betamethasone (Nasal)

About Betamethasone (Nasal)

Glucocorticoid steroid, seasonal or perennial allergic and nonallergic (vasomotor) .

Mechanism of Action of Betamethasone (Nasal)

Betamethasone exerts it`s pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemotaxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.Betamethasone can be given as a nasal spray to treat and prevent the inflammation that can occur in conditions such as allergies.

Pharmacokinets of Betamethasone (Nasal)

N/A

Onset of Action for Betamethasone (Nasal)

N/A

Duration of Action for Betamethasone (Nasal)

N/A

Half Life of Betamethasone (Nasal)

N/A

Side Effects of Betamethasone (Nasal)

1.Bronchospasm
2.Epistaxis
3.Smell and taste disturbances
4.Irritation of the tissues in the nose
5.Dryness of the nose and throat
6.Local sensitivity reactions

Contra-indications of Betamethasone (Nasal)

1.Perforated ear drum
2.After nasal surgery
3.Tuberculosis

Special Precautions while taking Betamethasone (Nasal)

1.Glaucoma
2.Herpes-type infection of the eye infection
3.Recent nasal surgery
4.Nasal sores
5.Liver disease
6.Tuberculosis
7.Underactive thyroid

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Use with caution

Indications for Betamethasone (Nasal)

1.Otitis externa
2.Non-allergic rhinitis

Interactions for Betamethasone (Nasal)

N/A

Typical Dosage for Betamethasone (Nasal)

Appy the medicament as directed by the Physician

Schedule of Betamethasone (Nasal)

N/A

Storage Requirements for Betamethasone (Nasal)

Store this medication at room temperature away from moisture and heat.Keep out of the reach of children.

Effects of Missed Dosage of Betamethasone (Nasal)

Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Betamethasone (Nasal)

Give supportive measures and symptomatic treatment.

Naphazoline

About Naphazoline

Imidazoline derivative,Alpha-adrenergic agonist, A decongestant,vasoconstrictor.

Mechanism of Action of Naphazoline

Naphazoline exerts its vasoconstrictor action by acting as a selective alpha-1 adrenergic agonist. Thus it reduces blood flow, and causes shrinkage of mucosa which provides relief of nasal congestion.

Pharmacokinets of Naphazoline

Absorption:It is well absorbed intranasally

Onset of Action for Naphazoline

10minutes

Duration of Action for Naphazoline

2 - 6 hours

Half Life of Naphazoline

N/A

Side Effects of Naphazoline

1.Rebound nasal congestion
2.Sneezing
3.Stinging
4.Dryness of mucosa

Contra-indications of Naphazoline

Hypersensitivity to Naphazoline

Special Precautions while taking Naphazoline

1.Prolonged use
2.Untreated nasal infection
3.Hyperthyroidism
4.Cardiac diseases
5.Hypertension
6.Diabetic mellitus

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

Use with caution

Indications for Naphazoline

Nasal congestion

Interactions for Naphazoline

N/A

Typical Dosage for Naphazoline

Adult:
Instil 1 -2 drops of or sprays into the nostrils whenever necessary. Dose can be repeated every 3 - 6 hours if needed up to 5 days.
Children:
Above 12years: same as adult dose
6 - 12 years: 1- 2 drops or sprays into the nostrils as needed

Schedule of Naphazoline

N/A

Storage Requirements for Naphazoline

Store at room temperature in a tightly closed container. Keep away from children.

Effects of Missed Dosage of Naphazoline

Instil the missed dose of nasal drop in to the nostrils as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Naphazoline

Provide supportive measures and symptomatic treatment.

Neomycin (Nasal)

About Neomycin (Nasal)

An aminoglycoside, Antibiotic in bacterial infections of nose.

Mechanism of Action of Neomycin (Nasal)

This aminoglycoside cause protein synthesis inhibition by "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically Neomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.

Pharmacokinets of Neomycin (Nasal)

N/A

Onset of Action for Neomycin (Nasal)

N/A

Duration of Action for Neomycin (Nasal)

N/A

Half Life of Neomycin (Nasal)

N/A

Side Effects of Neomycin (Nasal)

1.Irritation
2.Dryness
3.Sneezing
4.Headache
5.Lightheadedness
6.Itching
7.Feeling sick
8.Nose bleeds
9.Loss of smell

Contra-indications of Neomycin (Nasal)

1.Hypersensitivity to Neomycin
2.Fungal infections of the nose

Special Precautions while taking Neomycin (Nasal)

Prolonged use

Pregnancy Related Information

contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

contraindicated

Children Related Information

Use with caution

Indications for Neomycin (Nasal)

Bacterial infection of the nose

Interactions for Neomycin (Nasal)

N/A

Typical Dosage for Neomycin (Nasal)

2 - 3 drops instilled into the each nostrils 2 - 3 times a day.

Schedule of Neomycin (Nasal)

N/A

Storage Requirements for Neomycin (Nasal)

Stored at controlled room temperature. Protect from light and excessive heat. Keep out of reach of children.

Effects of Missed Dosage of Neomycin (Nasal)

Instil the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Neomycin (Nasal)

Give supportive measures and symptomatic treatment.

Home Delivery for Betamethasone (Nasal) + Naphazoline + Neomycin (Nasal) in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for betamethasone (nasal) + naphazoline + neomycin (nasal) and other medicines and health products. Home delivery services for betamethasone (nasal) + naphazoline + neomycin (nasal) may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take betamethasone (nasal) + naphazoline + neomycin (nasal) only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for betamethasone (nasal) + naphazoline + neomycin (nasal) before they complete the sale. You can get this information while placing the order for betamethasone (nasal) + naphazoline + neomycin (nasal) with the pharmacy.

Betamethasone (Nasal) + Naphazoline + Neomycin (Nasal) is a generic medicine name and there are several brands available for it. Some of the brands for betamethasone (nasal) + naphazoline + neomycin (nasal) might be better known than betamethasone (nasal) + naphazoline + neomycin (nasal) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have betamethasone (nasal) + naphazoline + neomycin (nasal) in stock, you can ask for one of the branded alternatives for betamethasone (nasal) + naphazoline + neomycin (nasal).