Hydrocortisone (Nasal) + Naphazoline Pharmacology

Hydrocortisone (Nasal) + Naphazoline

About Hydrocortisone (Nasal) + Naphazoline

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Mechanism of Action of Hydrocortisone (Nasal) + Naphazoline

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Pharmacokinets of Hydrocortisone (Nasal) + Naphazoline

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Onset of Action for Hydrocortisone (Nasal) + Naphazoline

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Duration of Action for Hydrocortisone (Nasal) + Naphazoline

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Half Life of Hydrocortisone (Nasal) + Naphazoline

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Side Effects of Hydrocortisone (Nasal) + Naphazoline

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Contra-indications of Hydrocortisone (Nasal) + Naphazoline

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Special Precautions while taking Hydrocortisone (Nasal) + Naphazoline

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Pregnancy Related Information

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Old Age Related Information

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Breast Feeding Related Information

N/A

Children Related Information

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Indications for Hydrocortisone (Nasal) + Naphazoline

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Interactions for Hydrocortisone (Nasal) + Naphazoline

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Typical Dosage for Hydrocortisone (Nasal) + Naphazoline

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Schedule of Hydrocortisone (Nasal) + Naphazoline

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Storage Requirements for Hydrocortisone (Nasal) + Naphazoline

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Effects of Missed Dosage of Hydrocortisone (Nasal) + Naphazoline

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Effects of Overdose of Hydrocortisone (Nasal) + Naphazoline

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Hydrocortisone (Nasal)

About Hydrocortisone (Nasal)

Synthetic glucocorticoid, Nasal anti-inflammatory.

Mechanism of Action of Hydrocortisone (Nasal)

The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows its migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts both glucocorticoid and mineralocorticoid actions.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction. Hydrocortisone is used as nasal preparation along with decongestants. Hydrocortisone suppresses the inflammatory reaction in the nasal cavities.

Pharmacokinets of Hydrocortisone (Nasal)

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Onset of Action for Hydrocortisone (Nasal)

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Duration of Action for Hydrocortisone (Nasal)

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Half Life of Hydrocortisone (Nasal)

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Side Effects of Hydrocortisone (Nasal)

1.Lightheadedness
2.Headache
3.Sneezing
4.Nasal irritation
5.Stinging
6.Drying of nasal tissue

Contra-indications of Hydrocortisone (Nasal)

Viral, fungal,tuberculous or purulent infections

Special Precautions while taking Hydrocortisone (Nasal)

1.Avoid prolonged use
2.Untreated nasal infection

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Use with caution

Indications for Hydrocortisone (Nasal)

1.Common cold
2.Allergic rhinitis
3.Vasomotor rhinitis
4.Sinusitis.

Interactions for Hydrocortisone (Nasal)

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Typical Dosage for Hydrocortisone (Nasal)

Instill the drop into the nasal cavity 2 - 4 times daily.

Schedule of Hydrocortisone (Nasal)

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Storage Requirements for Hydrocortisone (Nasal)

Store this medication at room temperature away from moisture and heat.

Effects of Missed Dosage of Hydrocortisone (Nasal)

Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Hydrocortisone (Nasal)

Give supportive measures and symptomatic treatment.

Naphazoline

About Naphazoline

Imidazoline derivative,Alpha-adrenergic agonist, A decongestant,vasoconstrictor.

Mechanism of Action of Naphazoline

Naphazoline exerts its vasoconstrictor action by acting as a selective alpha-1 adrenergic agonist. Thus it reduces blood flow, and causes shrinkage of mucosa which provides relief of nasal congestion.

Pharmacokinets of Naphazoline

Absorption:It is well absorbed intranasally

Onset of Action for Naphazoline

10minutes

Duration of Action for Naphazoline

2 - 6 hours

Half Life of Naphazoline

N/A

Side Effects of Naphazoline

1.Rebound nasal congestion
2.Sneezing
3.Stinging
4.Dryness of mucosa

Contra-indications of Naphazoline

Hypersensitivity to Naphazoline

Special Precautions while taking Naphazoline

1.Prolonged use
2.Untreated nasal infection
3.Hyperthyroidism
4.Cardiac diseases
5.Hypertension
6.Diabetic mellitus

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

Use with caution

Indications for Naphazoline

Nasal congestion

Interactions for Naphazoline

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Typical Dosage for Naphazoline

Adult:
Instil 1 -2 drops of or sprays into the nostrils whenever necessary. Dose can be repeated every 3 - 6 hours if needed up to 5 days.
Children:
Above 12years: same as adult dose
6 - 12 years: 1- 2 drops or sprays into the nostrils as needed

Schedule of Naphazoline

N/A

Storage Requirements for Naphazoline

Store at room temperature in a tightly closed container. Keep away from children.

Effects of Missed Dosage of Naphazoline

Instil the missed dose of nasal drop in to the nostrils as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Naphazoline

Provide supportive measures and symptomatic treatment.

Home Delivery for Hydrocortisone (Nasal) + Naphazoline in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including hydrocortisone (nasal) + naphazoline.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for hydrocortisone (nasal) + naphazoline and other medicines and health products. Home delivery services for hydrocortisone (nasal) + naphazoline may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take hydrocortisone (nasal) + naphazoline only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for hydrocortisone (nasal) + naphazoline before they complete the sale. You can get this information while placing the order for hydrocortisone (nasal) + naphazoline with the pharmacy.

Hydrocortisone (Nasal) + Naphazoline is a generic medicine name and there are several brands available for it. Some of the brands for hydrocortisone (nasal) + naphazoline might be better known than hydrocortisone (nasal) + naphazoline itself. If the pharmacy that's willing to deliver medicines to your home doesn't have hydrocortisone (nasal) + naphazoline in stock, you can ask for one of the branded alternatives for hydrocortisone (nasal) + naphazoline.