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- Pharmacology For Valdecoxib + Serratiopeptidase
Valdecoxib + Serratiopeptidase Pharmacology
Valdecoxib + Serratiopeptidase
About Valdecoxib + SerratiopeptidaseN/AMechanism of Action of Valdecoxib + SerratiopeptidaseN/APharmacokinets of Valdecoxib + SerratiopeptidaseN/AOnset of Action for Valdecoxib + SerratiopeptidaseN/ADuration of Action for Valdecoxib + SerratiopeptidaseN/AHalf Life of Valdecoxib + SerratiopeptidaseN/ASide Effects of Valdecoxib + SerratiopeptidaseN/AContra-indications of Valdecoxib + SerratiopeptidaseN/ASpecial Precautions while taking Valdecoxib + SerratiopeptidaseN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Valdecoxib + SerratiopeptidaseN/AInteractions for Valdecoxib + SerratiopeptidaseN/ATypical Dosage for Valdecoxib + SerratiopeptidaseN/ASchedule of Valdecoxib + SerratiopeptidaseN/AStorage Requirements for Valdecoxib + SerratiopeptidaseN/AEffects of Missed Dosage of Valdecoxib + SerratiopeptidaseN/AEffects of Overdose of Valdecoxib + SerratiopeptidaseN/AValdecoxib
About ValdecoxibNSAID,a COX-2 inhibitor, a diaryl substituted isoxazole, Analgesic,antiinflammatory,antiarthritic.Mechanism of Action of ValdecoxibThis NSAID inhibit COX2 enzyme selectively (COX-2 is only produced in response to tissue injury and causes tissue inflammation, and thus pain. It works by converting arachidonic acid into a specific prostaglandin which communicates the need for inflammation to the surrounding tissue). This results the anti-inflammatory action.
Pharmacokinets of ValdecoxibAbsorption- Well absorbed after oral administration.
Distribution- Widely distributed in the body as its plasma protein bound form. 98% bound to the plasma proteins.
Metabolism-It is metabolized in the liver.
Excretion- Excreted through urine and faeces.
Onset of Action for ValdecoxibN/ADuration of Action for ValdecoxibN/AHalf Life of ValdecoxibN/ASide Effects of Valdecoxib1. Diarrhea
2. Constipation
3. Sore throat
4. Cough
5. Runny nose
6. Fever
7. Blisters
8. Hives
9. Itching
10. Swelling of the eyes, face, tongue, lips, throat, arms, hands, feet, ankles, or lower legs
11. Difficulty in breathing or swallowing
12. Hoarseness
13. Pale skin
14. Fast heartbeat
15. Weight gain
16. Upset stomach
17. Tiredness
18. Pain in the right upper part of the stomach
19. Flu-like symptoms
20. Cloudy, discolored, or bloody urine
21. Back pain
22. Difficult or painful urination
Contra-indications of Valdecoxib1. Hypersensitivity to the drug
2. Hepatic insufficiency
3. Renal insufficiency
Special Precautions while taking Valdecoxib1. Alcohol abuse
2. Bleeding problems
3. Stomach ulcer
4. Tobacco abuse
5. Anemia
6. Asthma
7. Dehydration
8. Fluid retention (swelling of feet or lower legs)
9. High blood pressure
10. Kidney disease
11. Liver disease
12. Coronary artery bypass graft (CABG) surgery
13. Heart disease
Pregnancy Related InformationContraindicated
Old Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Valdecoxib1. Dysmenorrhea (pain with your menstrual period)
2. Osteoarthritis
3. Rheumatoid arthritis
4. Acute gout
Interactions for ValdecoxibCoadministration with fluconazole and ketoconazole : Enhances the total plasma exposure (AUC) of valdecoxib.
Coadministration with warfarin: Causes a significant increase in plasma exposure of warfarin.
Typical Dosage for ValdecoxibOral-
Adults-
Osteoarthritis & rheumatoid arthritis - 10mg once a day.
Dysmenorrhea- 20- 40mg daily.
Schedule of ValdecoxibN/AStorage Requirements for ValdecoxibStore at room temperature away from moisture and heat.Effects of Missed Dosage of ValdecoxibTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ValdecoxibGive symptomatic and supportive treatment. Induce gastric emesis and administer activated charcoal to reduce further adsorption of drugs.Serratiopeptidase
About SerratiopeptidaseA proteolytic enzyme, A powerful anti-inflammatory, anti-edemic.Mechanism of Action of SerratiopeptidaseThis anti-inflammatory proteolytic enzyme bind to the alpha-2-macroglobulin in the blood, which helps to mask its antigenicity.Then it is slowly transferred to the site of inflammation. Serratiopeptidase hydrolyze bradykinin, histamine, serotoxin responsible for oedema.It reduces swelling improves microcirculation and expectoration of sputum. Due to this action Serratiopeptidase has anti-inflammatory, antioedemic and fibrinolytic activity and act rapidly on localized inflammation.Pharmacokinets of SerratiopeptidaseOrally absorbed. In the case of enteric coated tablet absorption take place in the intestine. After absorption it is directly enter in to the bloodstream. It is excreted via urine and bile.Onset of Action for SerratiopeptidaseN/ADuration of Action for Serratiopeptidase8 to 10 hrsHalf Life of SerratiopeptidaseN/ASide Effects of Serratiopeptidase1. Hypersensitivity
2. Anorexia
3. Gastric discomfort
4. Nausea
5. Vomiting
6. Epistaxis
7. Diarrhoea
8. Skin rash
Contra-indications of Serratiopeptidase1. Hypersensitivity to this drug
2. Blood coagulation disorder
Special Precautions while taking Serratiopeptidase1. In patients with renal failure or hepatic failurePregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Serratiopeptidase1. Antiinflammatory
2. Antiswelling
3. Anti- rheumatoid
4. To promote transfer of antibiotics to the site of action
5. To promote lysis and discharge of sputum and pus
6. Bronchitis
7. Fibrocystic breast swelling
8. Sinusitis
9. Cough
10. Laryngitis
11. Fibromyalgia
12. Emphysema
13. Gout
Interactions for SerratiopeptidaseN/ATypical Dosage for SerratiopeptidaseOral-
Adults-5 to 10mg tab every 3 times daily.
10- 30 mg tab /day.
Schedule of SerratiopeptidaseN/AStorage Requirements for SerratiopeptidaseStore below 25 degree Celsius, protect from light and moisture.Effects of Missed Dosage of SerratiopeptidaseTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of SerratiopeptidaseGive supportive measures and symptomatic treatment.Home Delivery for Valdecoxib + Serratiopeptidase in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including valdecoxib + serratiopeptidase.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for valdecoxib + serratiopeptidase and other medicines and health products. Home delivery services for valdecoxib + serratiopeptidase may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take valdecoxib + serratiopeptidase only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for valdecoxib + serratiopeptidase before they complete the sale. You can get this information while placing the order for valdecoxib + serratiopeptidase with the pharmacy.
Valdecoxib + Serratiopeptidase is a generic medicine name and there are several brands available for it. Some of the brands for valdecoxib + serratiopeptidase might be better known than valdecoxib + serratiopeptidase itself. If the pharmacy that's willing to deliver medicines to your home doesn't have valdecoxib + serratiopeptidase in stock, you can ask for one of the branded alternatives for valdecoxib + serratiopeptidase.
