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- Pharmacology For Valdecoxib + Serratiopeptidase
Valdecoxib + Serratiopeptidase Pharmacology
Valdecoxib + SerratiopeptidaseAbout Valdecoxib + SerratiopeptidaseN/AMechanism of Action of Valdecoxib + SerratiopeptidaseN/APharmacokinets of Valdecoxib + SerratiopeptidaseN/AOnset of Action for Valdecoxib + SerratiopeptidaseN/ADuration of Action for Valdecoxib + SerratiopeptidaseN/AHalf Life of Valdecoxib + SerratiopeptidaseN/ASide Effects of Valdecoxib + SerratiopeptidaseN/AContra-indications of Valdecoxib + SerratiopeptidaseN/ASpecial Precautions while taking Valdecoxib + SerratiopeptidaseN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Valdecoxib + SerratiopeptidaseN/AInteractions for Valdecoxib + SerratiopeptidaseN/ATypical Dosage for Valdecoxib + SerratiopeptidaseN/ASchedule of Valdecoxib + SerratiopeptidaseN/AStorage Requirements for Valdecoxib + SerratiopeptidaseN/AEffects of Missed Dosage of Valdecoxib + SerratiopeptidaseN/AEffects of Overdose of Valdecoxib + SerratiopeptidaseN/A
ValdecoxibAbout ValdecoxibNSAID,a COX-2 inhibitor, a diaryl substituted isoxazole, Analgesic,antiinflammatory,antiarthritic.Mechanism of Action of ValdecoxibThis NSAID inhibit COX2 enzyme selectively (COX-2 is only produced in response to tissue injury and causes tissue inflammation, and thus pain. It works by converting arachidonic acid into a specific prostaglandin which communicates the need for inflammation to the surrounding tissue). This results the anti-inflammatory action.
Pharmacokinets of ValdecoxibAbsorption- Well absorbed after oral administration.
Distribution- Widely distributed in the body as its plasma protein bound form. 98% bound to the plasma proteins.
Metabolism-It is metabolized in the liver.
Excretion- Excreted through urine and faeces.
Onset of Action for ValdecoxibN/ADuration of Action for ValdecoxibN/AHalf Life of ValdecoxibN/ASide Effects of Valdecoxib1. Diarrhea
3. Sore throat
5. Runny nose
10. Swelling of the eyes, face, tongue, lips, throat, arms, hands, feet, ankles, or lower legs
11. Difficulty in breathing or swallowing
13. Pale skin
14. Fast heartbeat
15. Weight gain
16. Upset stomach
18. Pain in the right upper part of the stomach
19. Flu-like symptoms
20. Cloudy, discolored, or bloody urine
21. Back pain
22. Difficult or painful urination
Contra-indications of Valdecoxib1. Hypersensitivity to the drug
2. Hepatic insufficiency
3. Renal insufficiency
Special Precautions while taking Valdecoxib1. Alcohol abuse
2. Bleeding problems
3. Stomach ulcer
4. Tobacco abuse
8. Fluid retention (swelling of feet or lower legs)
9. High blood pressure
10. Kidney disease
11. Liver disease
12. Coronary artery bypass graft (CABG) surgery
13. Heart disease
Pregnancy Related InformationContraindicated
Old Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Valdecoxib1. Dysmenorrhea (pain with your menstrual period)
3. Rheumatoid arthritis
4. Acute gout
Interactions for ValdecoxibCoadministration with fluconazole and ketoconazole : Enhances the total plasma exposure (AUC) of valdecoxib.
Coadministration with warfarin: Causes a significant increase in plasma exposure of warfarin.
Typical Dosage for ValdecoxibOral-
Osteoarthritis & rheumatoid arthritis - 10mg once a day.
Dysmenorrhea- 20- 40mg daily.
Schedule of ValdecoxibN/AStorage Requirements for ValdecoxibStore at room temperature away from moisture and heat.Effects of Missed Dosage of ValdecoxibTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ValdecoxibGive symptomatic and supportive treatment. Induce gastric emesis and administer activated charcoal to reduce further adsorption of drugs.
SerratiopeptidaseAbout SerratiopeptidaseA proteolytic enzyme, A powerful anti-inflammatory, anti-edemic.Mechanism of Action of SerratiopeptidaseThis anti-inflammatory proteolytic enzyme bind to the alpha-2-macroglobulin in the blood, which helps to mask its antigenicity.Then it is slowly transferred to the site of inflammation. Serratiopeptidase hydrolyze bradykinin, histamine, serotoxin responsible for oedema.It reduces swelling improves microcirculation and expectoration of sputum. Due to this action Serratiopeptidase has anti-inflammatory, antioedemic and fibrinolytic activity and act rapidly on localized inflammation.Pharmacokinets of SerratiopeptidaseOrally absorbed. In the case of enteric coated tablet absorption take place in the intestine. After absorption it is directly enter in to the bloodstream. It is excreted via urine and bile.Onset of Action for SerratiopeptidaseN/ADuration of Action for Serratiopeptidase8 to 10 hrsHalf Life of SerratiopeptidaseN/ASide Effects of Serratiopeptidase1. Hypersensitivity
3. Gastric discomfort
8. Skin rash
Contra-indications of Serratiopeptidase1. Hypersensitivity to this drug
2. Blood coagulation disorder
Special Precautions while taking Serratiopeptidase1. In patients with renal failure or hepatic failurePregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Serratiopeptidase1. Antiinflammatory
3. Anti- rheumatoid
4. To promote transfer of antibiotics to the site of action
5. To promote lysis and discharge of sputum and pus
7. Fibrocystic breast swelling
Interactions for SerratiopeptidaseN/ATypical Dosage for SerratiopeptidaseOral-
Adults-5 to 10mg tab every 3 times daily.
10- 30 mg tab /day.
Schedule of SerratiopeptidaseN/AStorage Requirements for SerratiopeptidaseStore below 25 degree Celsius, protect from light and moisture.Effects of Missed Dosage of SerratiopeptidaseTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of SerratiopeptidaseGive supportive measures and symptomatic treatment.
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