Mometasone (Nasal) Pharmacology

Mometasone (Nasal)

About Mometasone (Nasal)
A glucocorticoid steroid, upper (nasal sinus inflammation,allergic rhinitis) respiratory condition.
Mechanism of Action of Mometasone (Nasal)
Mometasone is a topical medium potency glucocorticoid. The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows its migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits Phospholipase A2 and thus decreases the production of Prostaglandins, leukotrienes (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-a, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Mometasone (Nasal)
Absorption:It is administered as spray through the nostrils.
Onset of Action for Mometasone (Nasal)
N/A
Duration of Action for Mometasone (Nasal)
N/A
Half Life of Mometasone (Nasal)
N/A
Side Effects of Mometasone (Nasal)
1.Difficulty breathing
2.Closing of throat
3.Swelling of lips tongue, or face
4.Hives
Contra-indications of Mometasone (Nasal)
1.Hypersensitivity to Mometasone and other corticosteroids
Special Precautions while taking Mometasone (Nasal)
1.Viral, bacterial, or fungal infection
2.Nasal septum ulcer
3.Nasal surgery
4.Nasal damage
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Below 3 years: Contraindicated
Indications for Mometasone (Nasal)
1.Sneezing
2.Runny nose
3.Allergic rhinitis
4.Nasal polyps
Interactions for Mometasone (Nasal)
N/A
Typical Dosage for Mometasone (Nasal)
Instil the drops into the nostrils 3 - 4 times daily.
Schedule of Mometasone (Nasal)
N/A
Storage Requirements for Mometasone (Nasal)
Store Mometasone nasal at room temperature away from moisture and heat.Keep out of the reach of children.
Effects of Missed Dosage of Mometasone (Nasal)
Instil the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Mometasone (Nasal)
Give supportive measures and symptomatic treatment.

Home Delivery for Mometasone (Nasal) in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including mometasone (nasal).

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for mometasone (nasal) and other medicines and health products. Home delivery services for mometasone (nasal) may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take mometasone (nasal) only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for mometasone (nasal) before they complete the sale. You can get this information while placing the order for mometasone (nasal) with the pharmacy.

Mometasone (Nasal) is a generic medicine name and there are several brands available for it. Some of the brands for mometasone (nasal) might be better known than mometasone (nasal) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mometasone (nasal) in stock, you can ask for one of the branded alternatives for mometasone (nasal).