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- Pharmacology For Valdecoxib + Trypsin-Chymotrypsin
Valdecoxib + Trypsin-Chymotrypsin Pharmacology
Valdecoxib + Trypsin-ChymotrypsinAbout Valdecoxib + Trypsin-ChymotrypsinN/AMechanism of Action of Valdecoxib + Trypsin-ChymotrypsinN/APharmacokinets of Valdecoxib + Trypsin-ChymotrypsinN/AOnset of Action for Valdecoxib + Trypsin-ChymotrypsinN/ADuration of Action for Valdecoxib + Trypsin-ChymotrypsinN/AHalf Life of Valdecoxib + Trypsin-ChymotrypsinN/ASide Effects of Valdecoxib + Trypsin-ChymotrypsinN/AContra-indications of Valdecoxib + Trypsin-ChymotrypsinN/ASpecial Precautions while taking Valdecoxib + Trypsin-ChymotrypsinN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Valdecoxib + Trypsin-ChymotrypsinN/AInteractions for Valdecoxib + Trypsin-ChymotrypsinN/ATypical Dosage for Valdecoxib + Trypsin-ChymotrypsinN/ASchedule of Valdecoxib + Trypsin-ChymotrypsinN/AStorage Requirements for Valdecoxib + Trypsin-ChymotrypsinN/AEffects of Missed Dosage of Valdecoxib + Trypsin-ChymotrypsinN/AEffects of Overdose of Valdecoxib + Trypsin-ChymotrypsinN/A
ValdecoxibAbout ValdecoxibNSAID,a COX-2 inhibitor, a diaryl substituted isoxazole, Analgesic,antiinflammatory,antiarthritic.Mechanism of Action of ValdecoxibThis NSAID inhibit COX2 enzyme selectively (COX-2 is only produced in response to tissue injury and causes tissue inflammation, and thus pain. It works by converting arachidonic acid into a specific prostaglandin which communicates the need for inflammation to the surrounding tissue). This results the anti-inflammatory action.
Pharmacokinets of ValdecoxibAbsorption- Well absorbed after oral administration.
Distribution- Widely distributed in the body as its plasma protein bound form. 98% bound to the plasma proteins.
Metabolism-It is metabolized in the liver.
Excretion- Excreted through urine and faeces.
Onset of Action for ValdecoxibN/ADuration of Action for ValdecoxibN/AHalf Life of ValdecoxibN/ASide Effects of Valdecoxib1. Diarrhea
3. Sore throat
5. Runny nose
10. Swelling of the eyes, face, tongue, lips, throat, arms, hands, feet, ankles, or lower legs
11. Difficulty in breathing or swallowing
13. Pale skin
14. Fast heartbeat
15. Weight gain
16. Upset stomach
18. Pain in the right upper part of the stomach
19. Flu-like symptoms
20. Cloudy, discolored, or bloody urine
21. Back pain
22. Difficult or painful urination
Contra-indications of Valdecoxib1. Hypersensitivity to the drug
2. Hepatic insufficiency
3. Renal insufficiency
Special Precautions while taking Valdecoxib1. Alcohol abuse
2. Bleeding problems
3. Stomach ulcer
4. Tobacco abuse
8. Fluid retention (swelling of feet or lower legs)
9. High blood pressure
10. Kidney disease
11. Liver disease
12. Coronary artery bypass graft (CABG) surgery
13. Heart disease
Pregnancy Related InformationContraindicated
Old Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Valdecoxib1. Dysmenorrhea (pain with your menstrual period)
3. Rheumatoid arthritis
4. Acute gout
Interactions for ValdecoxibCoadministration with fluconazole and ketoconazole : Enhances the total plasma exposure (AUC) of valdecoxib.
Coadministration with warfarin: Causes a significant increase in plasma exposure of warfarin.
Typical Dosage for ValdecoxibOral-
Osteoarthritis & rheumatoid arthritis - 10mg once a day.
Dysmenorrhea- 20- 40mg daily.
Schedule of ValdecoxibN/AStorage Requirements for ValdecoxibStore at room temperature away from moisture and heat.Effects of Missed Dosage of ValdecoxibTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ValdecoxibGive symptomatic and supportive treatment. Induce gastric emesis and administer activated charcoal to reduce further adsorption of drugs.
Trypsin-ChymotrypsinAbout Trypsin-ChymotrypsinA proteolytic enzyme, Debriding agent,antiinflammatory.Mechanism of Action of Trypsin-ChymotrypsinIt is a proteolytic enzyme; its function is the digestion of proteins.It cleaves the peptide bond only at the positively charged side chains of amino acids, lysine and arginine.Pharmacokinets of Trypsin-ChymotrypsinN/AOnset of Action for Trypsin-ChymotrypsinN/ADuration of Action for Trypsin-ChymotrypsinN/AHalf Life of Trypsin-ChymotrypsinN/ASide Effects of Trypsin-Chymotrypsin1.SensitisationContra-indications of Trypsin-Chymotrypsin1.Do not spary on arterial clotSpecial Precautions while taking Trypsin-ChymotrypsinN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Trypsin-Chymotrypsin1. Debriding agent for cleaning of narcotic wounds, ulcers, sinuses and fistulas
2. Anti-inflammatory agent for the treatment of bronchial asthma, bronchitis and thrombophlebitis
Interactions for Trypsin-ChymotrypsinN/ATypical Dosage for Trypsin-ChymotrypsinN/ASchedule of Trypsin-ChymotrypsinN/AStorage Requirements for Trypsin-ChymotrypsinN/AEffects of Missed Dosage of Trypsin-ChymotrypsinN/AEffects of Overdose of Trypsin-ChymotrypsinN/A
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