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- Pharmacology For Tranexamic acid + Mefenamic acid
Tranexamic acid + Mefenamic acid Pharmacology
Tranexamic acid + Mefenamic acid
About Tranexamic acid + Mefenamic acidN/AMechanism of Action of Tranexamic acid + Mefenamic acidN/APharmacokinets of Tranexamic acid + Mefenamic acidN/AOnset of Action for Tranexamic acid + Mefenamic acidN/ADuration of Action for Tranexamic acid + Mefenamic acidN/AHalf Life of Tranexamic acid + Mefenamic acidN/ASide Effects of Tranexamic acid + Mefenamic acidN/AContra-indications of Tranexamic acid + Mefenamic acidN/ASpecial Precautions while taking Tranexamic acid + Mefenamic acidN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Tranexamic acid + Mefenamic acidN/AInteractions for Tranexamic acid + Mefenamic acidN/ATypical Dosage for Tranexamic acid + Mefenamic acidN/ASchedule of Tranexamic acid + Mefenamic acidN/AStorage Requirements for Tranexamic acid + Mefenamic acidN/AEffects of Missed Dosage of Tranexamic acid + Mefenamic acidN/AEffects of Overdose of Tranexamic acid + Mefenamic acidN/ATranexamic Acid
About Tranexamic AcidLysine Analog, Hemostatic, competitive plasminogen activationinhibitor, Antifibrinolytic,Antihemophilic.Mechanism of Action of Tranexamic AcidTranexamic acid exerts antifibrinolytic effect by forming a reversible complex with plasminogen through the lysine binding site of fibrin and thus displaces the plasminogen from the fibrin surface ; preventing the binding of plasmin to fibrinogen or fibrin monomers. It inhibits the activation of plasminogen (i.e. formation of plasmin). It also acts as a weak non competitive inhibitor of plasmin and blocks it`s action on fibrin.Pharmacokinets of Tranexamic AcidAbsorption: About 40% is absorbed orally. Distribution: Widely distributed in the body. Excretion: Excreted mainly as unchanged drug.Onset of Action for Tranexamic AcidN/ADuration of Action for Tranexamic AcidN/AHalf Life of Tranexamic Acid2 hoursSide Effects of Tranexamic Acid1.Nausea
2.Diarrhoea
3.Gastrointestinal problems
4.Headache
5.Hypotension
6.Giddiness
7.Thrombophlebitis at injected vein
8.Impairment of Colour vision
Contra-indications of Tranexamic Acid1.Thromboembolic disorders
2.Subarachnoid haemorrhage
3.Massive upper urinary tract haemorrhage
4.Colour vision disorders
5.Thrombophlebitis
6.Hepatic impairment
7.Severe renal impairment
Special Precautions while taking Tranexamic Acid1.Avoid rapid I.V. administration
2.Lower dosage adjustment is required in renal impairment
3.Monitor liver functioning during long term use
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Tranexamic Acid1.Surgical procedures
2.Menorrhagia
3. Metrorrhagia
4.Post partum haemorrhage
5.Haemorrhage after abortion
6.Haemorrhage due to contraceptive device insertion
7.Tooth extractions and haemorrhage in other dental procedures
8.Epistaxis
9.Haemoptysis
10.Gastrointestinal bleeding
11.Prostatectomy
12.Tonsillectomy
13.Fibrinolysis
14.Ocular trauma
15.Orthopedic surgery
16.Cardiovascular surgery
Interactions for Tranexamic AcidN/ATypical Dosage for Tranexamic AcidOral: 3 to 4gm/day in 3 to 4 divided doses or 15 to 25mg/kg body wt. 3 to 4 times daily.
I.V.: 1.5 to 3gm/day in 3 divided doses or 10 to 15mg/kg body wt. 3 times daily. Administered as slow I.V. injection or as continuous infusion; at a rate of 25 to 50mg/kg/day.
Schedule of Tranexamic AcidN/AStorage Requirements for Tranexamic AcidStore below 25 degree C. and protects from light. Keep out of reach of children.
Effects of Missed Dosage of Tranexamic AcidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Tranexamic AcidTreatment is supportive and symptomatic. Remove drug from the body by induced emesis, gastric lavage and administer activated charcoal to reduce absorption. Maintain adequate diuresis with the aid of fluids and diuretics.Mefenamic Acid
About Mefenamic AcidNSAID, Analgesic,antiinflammatory.Mechanism of Action of Mefenamic AcidMefenamic acid has analgesic, anti-inflammatory and antipyretic action. It acts by inhibiting Prostaglandin (PGs) synthesis and their release at the site of injury. Prostaglandins cause tenderness and amplify the action of other analgesics. Mefenamic acid inhibits cyclo-oxygenase enzyme and antagonizes prostaglandin actions.Pharmacokinets of Mefenamic AcidAbsorption: Mefenamic acid is well absorbed after oral administration. Distribution: It is distributed in the body in protein bound form. Metabolism: It is metabolised in the liver. Excretion: Mefenamic acid and its metabolites are excreted mainly in the urine.Onset of Action for Mefenamic Acid1-2 hours.Duration of Action for Mefenamic Acid6 hours.Half Life of Mefenamic Acid2-4 hours.Side Effects of Mefenamic Acid1.Nausea
2.Vomiting
3.Anorexia
4.Diarrhoea
5.Gastrointestinal bleeding
6.Abdominal distress
7.Constipation
8.Peptic ulcer
9.Dyspepsia
10.Headache
11.Flatulence
12.Drowsiness
13.Insomnia
14.Agranulocytosis
15.Aplastic anaemia
16.Thrombocytopenia
17.Dizziness
18.Rash
Contra-indications of Mefenamic Acid1.Hypersensitivity to Mefenamic acid and other NSAIDs
2.Inflammatory bowel disease
3.Peptic ulcer
Special Precautions while taking Mefenamic Acid1.Hepatic impairment
2.Renal impairment
3.Hypertension
4.Gastrointestinal diseases
5.Pre existing asthma
6.Patient on anticoagulant therapy
7.Heart failure
8.Myocardial infarction
9.StrokePregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationBelow 14 years: contraindicated
NEONATES: used only to close the patent ductus arteriosus as IV form only
Indications for Mefenamic Acid1.Muscular aches
2.Primary Dysmenorrhoea
3.Headaches
4.Acute gout
5.Dental pain
6.Patent ductus arteriosus
Interactions for Mefenamic AcidN/ATypical Dosage for Mefenamic AcidAdult: initial dose: 500 mg followed by 250 mg every 6 hours. Treatment is continued maximum up to 1 week.
Children above 14 years:
500 mg followed by 250 mg every 6 hours. Treatment is continued maximum up to 1 week.
Children below 14 years: not recommended.
Schedule of Mefenamic AcidHStorage Requirements for Mefenamic AcidStore Mefenamic acid at room temperature in a tightly closed light resistant container.Effects of Missed Dosage of Mefenamic AcidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Mefenamic AcidGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.
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