Ifosfamide Pharmacology


About Ifosfamide
Alkylating Agent (Nitrogen Mustard), Antineoplastic
Mechanism of Action of Ifosfamide
In the liver drug undergo enzymatic activation into 4-hydroxyifosfamide.This alkylates the DNA by binding to N7 position of the guanine residue. This results cross linking/abnormal base pairing/scission of DNA strand. There is cross linking of nucleic acid with proteins can also takes place. The overall process is cell cycle nonspecific reaction.
Pharmacokinets of Ifosfamide
Absorption- Rapidly absorbed after intravenous administration
Distribution- Widely distributed in the body. It crosses the blood brain barrier.
Metabolism- Metabolized in the liver into its active and inactive metabolites.4-hydroxyifosfamide is its active metabolite.
Excretion- Excreted through urine.
Onset of Action for Ifosfamide
Duration of Action for Ifosfamide
Half Life of Ifosfamide
Its plasma half life is 4-15hrs
Side Effects of Ifosfamide
1. Nausea
2. Vomiting
3. Lowered resistance to infection
4. Bruising or unusual bleeding
5. Anemia
6. Weakness
7. Sore in mouth
8. Taste changes
9. Diarrhea
10. Loss of appetite
11. Visual changes
12. Black, tarry stools
13. Blood in urine or in stool
14. Cough or hoarseness
15. Fever
16. Chills
17. Somnolence
18. Confusion
19. Coma
20. Seizures
21. Ataxia
22. Hallucination
23. Depressive psychosis
24. Dizziness
25. Disorientation
26. Cranial nerve dysfunction
27. Hemorrhagic cystitis
28. Nephrotoxicity
29. Leucopenia
30. Thrombocytopenia
31. Myelosuppression
32. Liver enzyme elevation
33. Liver dysfunction
34. Alopecia
35. Metabolic acidosis
36. Infection
37. Phlebitis
38. Dermatitis
39. Allergy
Contra-indications of Ifosfamide
1. Hypersensitivity to the drug
2. Bone marrow suppression
Special Precautions while taking Ifosfamide
1. Bone marrow metastases
2. Granulocytopenia
3. Prior therapy with cytotoxic agents
4. Recent radiation therapy
5. Renal impairment
6. Hepatic impairment
7. Monitor haematological functions periodically

Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Use with caution
Indications for Ifosfamide
1. Testicular cancer
2. Breast cancer
3. Non-Hodgkins disease
4. Hodgkins disease
5. Soft tissue sarcoma
6. Osteogenic sarcoma
7. Lung cancer
8. Cervical cancer
9. Ovarian cancer
10. Lymphocytic lymphoma
11. Gastric cancer
12. Pancreatic cancer
13. Bladder cancer
14. Cancer of endometrium
15. Neuroblastoma
16. Wilm`s tumor

Interactions for Ifosfamide
Typical Dosage for Ifosfamide
1.2g/metre square/day for 5 days, the cycle is repeated for 3 weeks.
Schedule of Ifosfamide
Storage Requirements for Ifosfamide
Stored at controlled room temperature.
Effects of Missed Dosage of Ifosfamide
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Ifosfamide
Give symptomatic and supportive treatment. Supportive treatment include transfusion of blood components, antiemetics and bladder irrigation

Home Delivery for Ifosfamide in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ifosfamide.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ifosfamide and other medicines and health products. Home delivery services for ifosfamide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take ifosfamide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ifosfamide before they complete the sale. You can get this information while placing the order for ifosfamide with the pharmacy.

Ifosfamide is a generic medicine name and there are several brands available for it. Some of the brands for ifosfamide might be better known than ifosfamide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ifosfamide in stock, you can ask for one of the branded alternatives for ifosfamide.