Nabumetone Pharmacology


About Nabumetone
NSAID, arylalkanoic acid derivative, Analgesic, anti-inflammatory.
Mechanism of Action of Nabumetone
The parent compound is a prodrug, which undergoes hepatic biotransformation to the active component, 6-methoxy-2-naphthylacetic acid (6MNA), that is a potent inhibitor of prostaglandin synthesis, most likely through binding to the COX-1 and COX-2 receptors.Its action is more potent on COX2. This results its antipyretic, analgesics and anti-inflammatory action.
Pharmacokinets of Nabumetone
Absorption- Well absorbed after oral administration. Rapidly it undergoes biotransformation in the plasma to its active metabolite 6-methoxy-2-naphthylacetic acid (6MNA).
Distribution- Widely distributed in the body. 99% bound to plasma proteins
Metabolism-It is metabolized in the liver to its inactive metabolites. Excretion- Excreted through urine and feces
Onset of Action for Nabumetone
Duration of Action for Nabumetone
Half Life of Nabumetone
22-30 hours
Side Effects of Nabumetone
1. Diarrhea
2. Constipation
3. Gas
4. Dizziness
5. Headache
6. Dry mouth
7. Sores in the mouth
8. Nervousness
9. Difficulty falling asleep or staying asleep
10. Increased sweating
11. Ringing in the ears
12. Unexpected weight gain
13. Yellowing of the skin or eyes
14. Lack of energy
15. Loss of appetite
16. Upset stomach
17. Pain in the upper right part of the stomach
18. Flu-like symptoms
19. Fever
20. Blisters
21. Rash
22. Itching
23. Hives
24. Swelling of the eyes, face, lips, tongue, throat, arms, hands, feet ankles, or lower legs
25. Difficulty breathing or swallowing
26. Hoarseness
Contra-indications of Nabumetone
1. Hypersensitivity to it
2. Hypersensitivity to other NSAIDs
Special Precautions while taking Nabumetone
1. Renal impairment
2. Hepatic dysfunction
3. Heart failure
4. Hypertension
5. Condition which predispose to fluid retention
6. History of peptic ulcer
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Nabumetone
1. Rheumatoid arthritis
2. Osteoarthritis
3. Inflammatory conditions
4. Soft tissue injuries
5. Migraine
6. Gout
Interactions for Nabumetone
Couramine or other anticoagulants: Risk of ulceration or haemorrhage.
Diuretics: May diminish effectiveness and intensity of renal failure.
Acetaminophen: May increase the risk of renal damage.
Salicylates: May decrease the effectiveness of the drug.
Typical Dosage for Nabumetone
Osteoarthritis / Rheumatoid arthritis - 1g as a single dose with or without food
Soft tissue injuries- 2g per day taken in divided doses for a maximum of 7 days
Schedule of Nabumetone
Storage Requirements for Nabumetone
Store it at room temperature and away from excess heat and moisture
Effects of Missed Dosage of Nabumetone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Nabumetone
Give symptomatic and supportive treatment. Induce emesis or gastric lavage. Administer activated charcoal for the prevention of further absorption of the drug

Home Delivery for Nabumetone in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including nabumetone.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for nabumetone and other medicines and health products. Home delivery services for nabumetone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take nabumetone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for nabumetone before they complete the sale. You can get this information while placing the order for nabumetone with the pharmacy.

Nabumetone is a generic medicine name and there are several brands available for it. Some of the brands for nabumetone might be better known than nabumetone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have nabumetone in stock, you can ask for one of the branded alternatives for nabumetone.