Lomustine Pharmacology


About Lomustine
An alkylating nitrosourea compound, Antineoplastic.
Mechanism of Action of Lomustine
This highly lipophilic nitrosourea compound undergoes hydrolysis in vivo to form reactive metabolites. These metabolites cause alkylation and cross linking of DNA. This process slows down the synthesis of cancer cells. This drug also has been shown to affect a number of cellular processes including DNA, protein synthesis, processing of ribosomal &nucleoplasmic messenger RNA, DNA based component structure, the rate of DNA synthesis and DNA polymerase activity. These all processes is cell cycle-phase nonspecific.
Pharmacokinets of Lomustine
Absorption- Rapidly absorbed after oral administration.
Distribution - Widely distributed in the body. It crosses the blood brain barrier.
Metabolism- Metabolized in the liver to its active and inactive metabolites.
Excretion -Primarily excreted via urine. A small portion is excreted through feces and through lungs.
Onset of Action for Lomustine
3 hrs after oral administration
Duration of Action for Lomustine
16 to 48 hrs
Half Life of Lomustine
Its elimination half life is about 6 hrs for initial phase and 1 to 2 days for terminal phase.
Side Effects of Lomustine
1. Nausea
2. Vomiting
3. Lowered resistance to infection
4. Bruising or unusual bleeding
5. Anemia
6. Weakness
7. Sore in mouth
8. Taste changes
9. Diarrhea
10. Loss of appetite
11. Visual changes
12. Black, tarry stools
13. Blood in urine or in stool
14. Cough or hoarseness
15. Fever
16. Chills
17. Lower back or side pain
18. Painful or difficult urination
19. Pinpoint red spot on skin
20. Slurred speech
21. Swelling on leg or lower leg
22. Shortness of breath
23. Pulmonary fibrosis
24. Hepatotoxicity
25. Nephrotoxicity
26. Stomatitis
27. Disorientation
28. Lethargy
29. Ataxia
30. Thrombocytopenia
31. Leucopenia
32. Bone marrow suppression
Contra-indications of Lomustine
1. Hypersensitivity to the drug
2. Blood disorder
Special Precautions while taking Lomustine
1. Decreased platelet, WBC or RBC count
2. Renal impairment
3. Treatment with myelosupressive agents
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Use with caution
Indications for Lomustine
1. Brain tumor
2. Hodgkins disease
3. Lymphomas
4. Malignant melanoma
5. Solid tumor
6. Renal cancer
7. Colon cancer
8. Non Hodgkins disease
Interactions for Lomustine
Theophylline: Causes leucopenia and thrombocytopenia.
Typical Dosage for Lomustine
130mg/metre square as single dose every 6 weeks.
75 to 150mg/metre square as single dose every 6 weeks.
Schedule of Lomustine
Storage Requirements for Lomustine
Keep in tightly closed container at room temperature, away from heat and moisture. Keep out of reach of children.
Effects of Missed Dosage of Lomustine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Lomustine
Give symptomatic and supportive treatment.

Home Delivery for Lomustine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including lomustine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for lomustine and other medicines and health products. Home delivery services for lomustine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take lomustine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for lomustine before they complete the sale. You can get this information while placing the order for lomustine with the pharmacy.

Lomustine is a generic medicine name and there are several brands available for it. Some of the brands for lomustine might be better known than lomustine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have lomustine in stock, you can ask for one of the branded alternatives for lomustine.