Distribution- Widely distributed in the body. Large amounts are seen in liver, kidney and heart.70% bound to the plasma proteins.
Metabolism- Metabolized in the liver to its metabolites. Doxorubicinol is its major metabolite.
Excretion- Excreted via bile. A small portion is excreted through urine.
3. Loss of appetite
5. Difficulty in swallowing
6. Brittle hair
7. Skin irritation
12. Peeling of the skin on the palms and soles of the feet.
13. Tarry stools
16. Facial swelling
17. Bruising or unusual bleeding
19. Blood in urine or stools
23. Itching eyes
24. Change in taste
25. Muscle ache
26. Swelling of eyes and eyelid
27. Trouble sleeping
30.Left ventricular failure
2. Severe leucopenia
4. Previous treatment with antitumor agent or by radiotherapy
5. Cardiac disease
2. Kidney diseases
3. Renal diseases
4. Recent Immunization
2. Thyroid cancer
3. Breast cancer
4. Ovarian cancer
5. Gastric cancer
6. Soft tissue and osteogenic sarcomas
8. Wilm`s tumor
9. Hodgkins disease
10. Non Hodgkins disease
11. Acute myeloblastic leukemia
12. Acute lymphoblast leukemia
13. Kaposi`s sarcoma related to acquired immunodeficiency syndrome
14. Ewing`s tumor
15. Squamous cell carcinoma
16. Carcinomas of other parts
17. Multiple myeloma
Cyclophosphamide: Exacerbation of cyclophosphamide induced hemorrhagic cystitis.
Barbiturates: Increase the plasma clearance of doxorubicin.
Digoxin: Decreased serum levels of digoxin.
Streptozotocin: Increases toxicity of doxorubicin.
Radiation: Radiation induced toxicity to myocardium, mucosa, skin and liver increased.
60 to 75 mg/metre square single dose every 21 days
30mg/metre square daily every 3 days.
Home Delivery for Doxorubicin in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including doxorubicin.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for doxorubicin and other medicines and health products. Home delivery services for doxorubicin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take doxorubicin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for doxorubicin before they complete the sale. You can get this information while placing the order for doxorubicin with the pharmacy.
Doxorubicin is a generic medicine name and there are several brands available for it. Some of the brands for doxorubicin might be better known than doxorubicin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have doxorubicin in stock, you can ask for one of the branded alternatives for doxorubicin.