Mitoxantrone Pharmacology

Mitoxantrone

About Mitoxantrone
An Anthracenedione derivative, a type II topoisomerase inhibitor, Anti-neoplastic.
Mechanism of Action of Mitoxantrone
This drug shows its anticancer activity by different mechanisms. Drug intercalates the DNA cause inter/intra strand cross linking. The drug can also bind to the topoisomerase enzyme2, which is necessary for the cell to divide and so grow into 2 new cells. If the drug binds with DNA it gets tangled up and the cell cannot divide. This is cell cycle phase-nonspecific
Pharmacokinets of Mitoxantrone
Absorption- Rapidly absorbed after intravenous administration
Distribution - Widely distributed in the body.78% bound to the plasma proteins.
Metabolism- Metabolized in the liver to polar compounds
Excretion- Excreted via bile and a small amount through urine.35% as its inactive metabolite and 65% as its unchanged form
Onset of Action for Mitoxantrone
N/A
Duration of Action for Mitoxantrone
N/A
Half Life of Mitoxantrone
2.5 to 13 days
Side Effects of Mitoxantrone
1. Nausea
2. Vomiting
3. Lowered resistance to infection
4. Bruising or unusual bleeding
5. Anemia
6. Weakness
7. Sore in mouth
8. Taste changes
9. Diarrhea
10. Loss of appetite
11. Visual changes
12. Black, tarry stools
13. Blue or green urine
14. Cough or hoarseness
15. Fever
16. Chills
17. Lower back or side pain
18. Painful or difficult urination
19. Pinpoint red spot on skin
20. Slurred speech
21. Swelling on leg or lower leg
22. Shortness of breath
23. Bloody vomiting
24. Thinned or brittle hair
25. Mouth blistering
26. Seizures
27. Conjunctivitis
28. Temporary blue colour to sclera
29. Heart failure
30. Arrhythmias
31. Renal failure
32. Myelosuppression
33. Jaundice
34. Hyperurecemia
35. Cough
36. Alopecia
37. Echymoses
38. Sepsis
39. Fungal infections
Contra-indications of Mitoxantrone
1. Hypersensitivity to the drug
2. Severe Myelosuppression
3. Cardiac dysfunction
Special Precautions while taking Mitoxantrone
1. Recent radiotherapy
2. Recent chemotherapy
3. Pre existing cardiac diseases
4. Hepatic impairment
5. Prior exposure to anthracyclines
6. Regularly monitor patient`s blood count and cardiac function
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Mitoxantrone
1. Chronic myelogenous leukemia
2. Non Hodgkins disease
3. Breast cancer
4. Acute non lymphocytic leukemia
5. Hormone-refractory prostate cancer
6. Multiple sclerosis
7. Lymphomas
8. Gastric cancer
9. Liver cancer
10. Ovarian cancer
11. Prostate cancer
Interactions for Mitoxantrone
N/A
Typical Dosage for Mitoxantrone
Intravenous-
Adult-
For breast cancer and lymphoma
14mg/metre square every 3-4 weeks or 2-4mg/metre square/day for 5 days
For acute non lymphocytic leukemia
12mg/metre square daily for 5 days
Child-
Intravenous-
8mg/metre square daily for 5 days every 3 to 4 weeks
Schedule of Mitoxantrone
H
Storage Requirements for Mitoxantrone
Stored at temperature 15 to 25 degree Celsius. Avoid freezing.
Effects of Missed Dosage of Mitoxantrone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Mitoxantrone
Give symptomatic and supportive treatment. Provide antimicrobial therapy if necessary.

Home Delivery for Mitoxantrone in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including mitoxantrone.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for mitoxantrone and other medicines and health products. Home delivery services for mitoxantrone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take mitoxantrone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for mitoxantrone before they complete the sale. You can get this information while placing the order for mitoxantrone with the pharmacy.

Mitoxantrone is a generic medicine name and there are several brands available for it. Some of the brands for mitoxantrone might be better known than mitoxantrone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mitoxantrone in stock, you can ask for one of the branded alternatives for mitoxantrone.