Vinorelbine Pharmacology


About Vinorelbine
Semi-synthetic vinca alkaloid, anti-mitotic, Radiation-Sensitizing Agent, Antineoplastic.
Mechanism of Action of Vinorelbine
This semi synthetic alkaloid derivative inhibits the cell growth by binding and depolymerization of tubuline in metaphase. This inhibits the formation of microtubules. Due to this the newly replicated chromosomes cannot be separated and cell division is blocked. The aborted cell division process triggers cell death.
Pharmacokinets of Vinorelbine
Absorption- Rapidly absorbed after intravenous administration.
Distribution- Widely distributed in the body.80-90% bound to the plasma proteins. It crosses the blood brain barrier.
Metabolism- It metabolized in the liver to its metabolites. Deacetylvinorelbine is its active metabolite and vinorelbine N-oxide is its inactive metabolite.
Excretion- Excreted via urine (18%, 11% as unchanged form) and bile.
Onset of Action for Vinorelbine
Duration of Action for Vinorelbine
Half Life of Vinorelbine
28-44 hours
Side Effects of Vinorelbine
1. Nausea
2. Vomiting
3. Lowered resistance to infection
4. Bruising or unusual bleeding
5. Anemia
6. Weakness
7. Sore in mouth
8. Taste changes
9. Diarrhea
10. Loss of appetite
11. Visual changes
12. Black, tarry stools
13. Blood in urine or in stool
14. Cough or hoarseness
15. Fever
16. Chills
17. Lower back or side pain
18. Painful or difficult urination
19. Pinpoint red spot on skin
20. Slurred speech
21. Swelling on leg or lower leg
22. Shortness of breath
23. Pulmonary fibrosis
24. Hepatotoxicity
25. Nephrotoxicity
26. Stomatitis
27. Disorientation
28. Lethargy
29. Ataxia
30. Thrombocytopenia
31. Leucopenia
32. Bone marrow suppression
33. Myalgia
34. Musle weakness
35. Bronchospasm
36. Alopecia
Contra-indications of Vinorelbine
1. Hypersensitivity to the drug
2. Pretreatment granulocyte count <1000 cells/mm3
Special Precautions while taking Vinorelbine
Cautiously use in patients with :
1. Bone marrow suppression
2. Recent radiation therapy
3. Recent chemotherapy
4. Hepatic insufficiency
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Use with caution
Indications for Vinorelbine
1. Lung cancer (non-small cell and small cell)
2. Breast cancer
3. Cervical cancer
4. Ovarian cancer (epithelial)
5. Testicular cancer
6. Hodkins disease
7. Choriocarcinoma
8. Squamous cell carcinoma
9. Cancer of head and neck
10. Renal cell cancer
11. Kaposis sarcoma
Interactions for Vinorelbine
Cisplatin: Increased risk of bone marrow depression
Mitomycin: Produce pulmonary reactions
Typical Dosage for Vinorelbine
Adult -
30mg/metre square weekly over a period of 6- 10 minutes.
Schedule of Vinorelbine
Storage Requirements for Vinorelbine
Store under refrigerator at 2 -8 degree C. Protect from light. Do not freeze.
Effects of Missed Dosage of Vinorelbine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Vinorelbine
Give symptomatic and supportive treatment. Supportive treatment include transfusion of blood components and antibiotics as needed.

Home Delivery for Vinorelbine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including vinorelbine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for vinorelbine and other medicines and health products. Home delivery services for vinorelbine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take vinorelbine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for vinorelbine before they complete the sale. You can get this information while placing the order for vinorelbine with the pharmacy.

Vinorelbine is a generic medicine name and there are several brands available for it. Some of the brands for vinorelbine might be better known than vinorelbine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have vinorelbine in stock, you can ask for one of the branded alternatives for vinorelbine.