Teniposide Pharmacology

Teniposide

About Teniposide
A semisynthetic derivative of podophyllotoxin, mitotic inhibitor, Antineoplastic.
Mechanism of Action of Teniposide
Teniposide is a topoisomerase II inhibitor.Topoisomerase produces a break and reseals in double stranded DNA.Teniposide form a complex with topoisomeraseII and DNA and prevent resealing of the break.The enzyme remains bound to the free end of the broken DNA strand and leads to accumulation of DNA breaks and cell deathCells in the S and G2 phase of the cell cycle are most sensitive to Teniposide.
Pharmacokinets of Teniposide
PK: Absorption: It is completely absorbed after parenteral administration.

Onset of Action for Teniposide
N/A
Duration of Action for Teniposide
N/A
Half Life of Teniposide
5hours
Side Effects of Teniposide
1.Myelosuppression
2.Leukopenia
3.Neutropenia
4.Thrombocytopenia
5.Anemia
6.Mucositis
7.Diarrhea
8.Nausea
9.Vomiting
10.Infection
11.Alopecia
12.Bleeding
13.Hypersensitivity reactions
14.Rash
15.Fever
16.Hypotension/
17.Neurotoxicity
18.Hepatic dysfunction
19.Renal dysfunciton
20.Metabolic abnormalities
Contra-indications of Teniposide
Hypersensitivity to Teniposide
Special Precautions while taking Teniposide
N/A
Pregnancy Related Information
Contraindicated
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated
Children Related Information
N/A
Indications for Teniposide
Leukemia in children
Interactions for Teniposide
N/A
Typical Dosage for Teniposide
165mg/meter square IV with Cytarabine twice weekly for 8 - 9 doses
Schedule of Teniposide
N/A
Storage Requirements for Teniposide
Store at a temperature range of 2 to 8 degree C. Avoid freezing
Effects of Missed Dosage of Teniposide
The doctor should be informed immediately if a dose is missed
Effects of Overdose of Teniposide
Give supportive measures and symptomatic treatment.

Home Delivery for Teniposide in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including teniposide.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for teniposide and other medicines and health products. Home delivery services for teniposide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take teniposide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for teniposide before they complete the sale. You can get this information while placing the order for teniposide with the pharmacy.

Teniposide is a generic medicine name and there are several brands available for it. Some of the brands for teniposide might be better known than teniposide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have teniposide in stock, you can ask for one of the branded alternatives for teniposide.