Carboplatin Pharmacology


About Carboplatin
Alkylating Agent, Platinum Analog, A systemic antineoplastic Agent
Mechanism of Action of Carboplatin
This platinum co ordination complex hydrolyzed intracellularly to produce a highly reactive moiety, which causes cross linking of DNA at the site of N7 of guanine residue. It can also react with -SH groups in proteins and has radiomimetic property.
Pharmacokinets of Carboplatin
Absorption- Rapidly absorbed after intravenous administration Distribution- Widely distributed to the body water. It does not bind to the plasma proteins. The metal platinum in the drug after degradation bound to the plasma proteins (87%).
Metabolism- Metabolized into metabolites by hydroxylation
Excretion- Excreted through urine. Enterohepatic recirculation is also takes place.
Onset of Action for Carboplatin
Duration of Action for Carboplatin
Half Life of Carboplatin
Its plasma half-life is 2 hrs
Side Effects of Carboplatin
1. Nausea
2. Vomiting
3. Lowered resistance to infection
4. Bruising or unusual bleeding
5. Anemia
6. Weakness
7. sore in mouth
8. Taste changes
9. Diarrhea
10. Loss of appetite
11. Visual changes
12. Black, tarry stools
13. Blood in urine or in stool
14. Cough or hoarseness
15. Fever
16. Chills
17. Myelosuppression
18. Mucositis
19. Dermatitis
20. Angina
21. Heart attack
22. Alopecia
23. Conjunctivitis
24. Cardiac arrhythmias
25. Hyper pigmentation
26. Breathlessness
27. Euphoria
28. Ataxia
29. Nystagmus
30. Leucopenia
31. Thrombocytopenia
32. Anaphylaxis
33. Agranulocytosis
34. Myocardial ischemia
35. Raised alkaline phosphatase level
36. Serum electrolyte level abnormalities
37. Pain
38. Asthenia
39. Central neurotoxicity
40. Peripheral neuropathies
41. Ototoxicity
42. Blood urea level elevations
43. Embolism
44. Cerebrovascular accidents
45. Mucositis
Contra-indications of Carboplatin
1. Hypersensitivity to the drug, platinum containing compounds and mannitol
2. Severe bone marrow depression
3. Bleeding
Special Precautions while taking Carboplatin
1. Diminished renal function
2. Amino glycosides neurotoxicity
3. Liver function impairment
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Use with caution
NEONATES- Use with caution
Indications for Carboplatin
1. Ovarian carcinoma
2. Cancer of bladder
3. Breast cancer
4. Esophagus cancer
5. Cancer of fallopian tube
6. Cancer of head and neck
7. Lymphoma
8. Lung cancer
9. Cancer of endometrium
10. Cancer of unknown origin
11. Malignant melanoma
12. Retinoblastoma
13. Brain tumor
14. Testicular cancer
15. Wilms` tumor
Interactions for Carboplatin
Phenytoin : Serum concentration may be decreased resulting in loss of therapeutic effect.
Typical Dosage for Carboplatin
300-600mg/metre square i.v.infusion every 3-4 weeks
For brain tumors in children-
175mg/metre square weekly for 4 weeks, with a 2 weeks recovery period between courses

Schedule of Carboplatin
Storage Requirements for Carboplatin
Store at 15 -30 degree C temperature. Protect from light.
Effects of Missed Dosage of Carboplatin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Carboplatin
Give symptomatic and supportive treatment

Home Delivery for Carboplatin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including carboplatin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for carboplatin and other medicines and health products. Home delivery services for carboplatin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take carboplatin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for carboplatin before they complete the sale. You can get this information while placing the order for carboplatin with the pharmacy.

Carboplatin is a generic medicine name and there are several brands available for it. Some of the brands for carboplatin might be better known than carboplatin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have carboplatin in stock, you can ask for one of the branded alternatives for carboplatin.