Letrozole Pharmacology


About Letrozole
Non-steroidal Aromatase Inhibitor, Antineoplastic.
Mechanism of Action of Letrozole
This aromatase enzyme inhibitor, competitively and reversibly bind to the heme portion of cytochrome P450 unit of aromatase enzyme (which convert the androgens to estrogens) and inhibit its activity.
It causes the reduction in plasma estrogen level and then the growth of estrogen related tumors growth.
Pharmacokinets of Letrozole
Absorption- Absorbed rapidly and completely after oral administration. Distribution- Widely distribute in the body. It weakly bound to the plasma proteins.Metabolism- It is slowly metabolized in the liver to its metabolites by glucoronidation.4,4`-methanol-bisbenzonitrile is its inactive metabolite.
Excretion- It is excreted via urine.
Onset of Action for Letrozole
Duration of Action for Letrozole
Half Life of Letrozole
Side Effects of Letrozole
1. Osteoporosis
2. Hypo estrogen
3. Hot flushes
4. Nausea
5. Vomiting
6. Fatigue
7. Dizziness
8. Headache
9. Dyspepsia
10. Constipation
11. Diarrhea
12. Anorexia
13. Appetite increase
14. Alopecia
15. Increased sweating
16. Rash
17. Peripheral edema
18. Musculoskeletal pain
19. Pulmonary embolism
20. Arterial thrombosis
21. Cerebrovascular infarction
22. Somnolence
23. Asthenia
24. Hypercholesteremia
25. Bone pain
26. Extremities
27. Back pain
28. Arthralgias
29. Viral infections

Contra-indications of Letrozole
1. Hypersensitivity to the drug and its components
2. Severe hepatic impairment
3. Premenopausal woman

Special Precautions while taking Letrozole
1. Use with caution in patients with severe renal impairment
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Indications for Letrozole
1. Breast cancer especially in post menopausal woman.
2. Pre-operative treatment in post-menopausal women with localized hormone-receptor-positive breast cancer.
Interactions for Letrozole
Typical Dosage for Letrozole
2.5mg once daily.
Schedule of Letrozole
Storage Requirements for Letrozole
Stored at room temperature in a tightly closed container and protect from light and excessive heat. Keep out of reach of children.
Effects of Missed Dosage of Letrozole
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Letrozole
Give symptomatic and supportive treatment.

Home Delivery for Letrozole in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including letrozole.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for letrozole and other medicines and health products. Home delivery services for letrozole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take letrozole only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for letrozole before they complete the sale. You can get this information while placing the order for letrozole with the pharmacy.

Letrozole is a generic medicine name and there are several brands available for it. Some of the brands for letrozole might be better known than letrozole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have letrozole in stock, you can ask for one of the branded alternatives for letrozole.